UniProt:P22735 TGM1

chain
  • chain:1-817
  • chain:94-817
  • chain:574-817
checksum 4732F28234F5D5F1
comment
  • FUNCTION Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins (PubMed:7629111, PubMed:8824274, PubMed:26220141, PubMed:20663883). Responsible for cross-linking epidermal proteins during formation of the stratum corneum (PubMed:26220141). Involved in cell proliferation (PubMed:26220141).CATALYTIC ACTIVITY L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)COFACTOR Binds 1 Ca(2+) ion per subunit.INTERACTION Myristoylation and palmitoylation mediate the membrane localization.ALTERNATIVE PRODUCTS The membrane anchorage region possesses a cluster of five cysteines within which fatty acid(s) may become thioester-linked. It is subject to phorbol ester-stimulated phosphorylation and is hypersensitive to proteolysis, which releases the enzyme in a soluble form.PTM Tyrosine-phosphorylated.PTM The N-terminus is blocked.PTM Activated by proteolytic processing.PTM Myristoylated.PTM Palmitoylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the transglutaminase superfamily. Transglutaminase family.
crossReference
databaseName UniProt
dbId 65953
description
  • recommendedName: Protein-glutamine gamma-glutamyltransferase K ecNumber evidence="10 12 15"2.3.2.13 alternativeName: Epidermal TGase alternativeName: Transglutaminase K shortName: TG(K) shortName: TGK shortName: TGase K alternativeName: Transglutaminase-1 shortName: TGase-1 component recommendedName: fullName evidence="20"Protein-glutamine gamma-glutamyltransferase K 67 kDa chain /component component recommendedName: fullName evidence="20"Protein-glutamine gamma-glutamyltransferase K 33 kDa chain /component
displayName UniProt:P22735 TGM1
geneName
  • TGM1
  • KTG
identifier P22735
isSequenceChanged false
keyword
  • 3D-structure
  • Acyltransferase
  • Alternative splicing
  • Calcium
  • Cell membrane
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Ichthyosis
  • Keratinization
  • Lipoprotein
  • Membrane
  • Metal-binding
  • Palmitate
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transferase
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • TGM1
otherIdentifier
  • 11741819_a_at
  • 16791219
  • 206008_PM_at
  • 206008_at
  • 3558044
  • 3558045
  • 3558046
  • 3558047
  • 3558048
  • 3558049
  • 3558050
  • 3558051
  • 3558052
  • 3558054
  • 3558055
  • 3558056
  • 3558058
  • 3558059
  • 3558060
  • 3558061
  • 3558062
  • 3558063
  • 3558064
  • 3558065
  • 3558066
  • 3558067
  • 3558068
  • 3558070
  • 3558072
  • 35947_at
  • 7051
  • 7978222
  • A_23_P65618
  • GE58185
  • GO:0001533
  • GO:0003810
  • GO:0003824
  • GO:0005515
  • GO:0005829
  • GO:0005886
  • GO:0010838
  • GO:0016020
  • GO:0016740
  • GO:0016746
  • GO:0018149
  • GO:0030154
  • GO:0030216
  • GO:0031424
  • GO:0036211
  • GO:0042802
  • GO:0043163
  • GO:0045787
  • GO:0046872
  • GO:0048513
  • GO:0048856
  • GO:0070062
  • GO:0140096
  • HMNXSV003034728
  • ILMN_1721134
  • M98447_rna1_at
  • TC14000971.hg
  • g4507474_3p_at
  • g4507474_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TGM1_HUMAN
  • B4DWR7
  • Q197M4
sequenceLength 817
species [Species:48887] Homo sapiens
stId uniprot:P22735
url http://purl.uniprot.org/uniprot/P22735

Referrals

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