Reactome | UniProt:P22303 ACHE

Schema > ReferenceGeneProduct > Entries

UniProt:P22303 ACHE Show undefined attributes

chain	signal peptide:1-31 chain:32-614
checksum	B9AA84C77831C302
comment	FUNCTION Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis.CATALYTIC ACTIVITY acetylcholine + H2O = choline + acetate + H(+)SUBUNIT Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.INTERACTION Only observed in apoptotic nuclei.SUBCELLULAR LOCATION Isoform H is highly expressed in erythrocytes.POLYMORPHISM ACHE is responsible for the Yt blood group system [MIM:112100]. The molecular basis of the Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353 corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b).SIMILARITY Belongs to the type-B carboxylesterase/lipase family.ONLINE INFORMATION Acetylcholinesterase entry
crossReference	[DatabaseIdentifier:12191004] PDB:6O50 [DatabaseIdentifier:12818166] ZINC - World Drugs:ACES_HUMAN [DatabaseIdentifier:12814511] ZINC target:P22303 [DatabaseIdentifier:12811199] ZINC - Substances:ACES_HUMAN [DatabaseIdentifier:12808623] ZINC - Predictions - Purchasable:ACES_HUMAN [DatabaseIdentifier:12807937] ZINC - Metabolites:ACES_HUMAN [DatabaseIdentifier:12806663] ZINC - Investigational:ACES_HUMAN [DatabaseIdentifier:12805596] ZINC - FDA approved:ACES_HUMAN [DatabaseIdentifier:12804448] ZINC - Biogenic:ACES_HUMAN [DatabaseIdentifier:12419224] RefSeq:NP_001354844.1 [DatabaseIdentifier:12419221] RefSeq:NP_000656.1 [DatabaseIdentifier:12419223] RefSeq:NP_001289550.1 [DatabaseIdentifier:12419226] RefSeq:NP_001269378.1 [DatabaseIdentifier:12419225] RefSeq:NP_001354846.1 [DatabaseIdentifier:12419222] RefSeq:NP_001289551.1 [DatabaseIdentifier:12287508] Pharos - Targets:P22303 [DatabaseIdentifier:12247863] PRO:P22303 [DatabaseIdentifier:12191040] PDB:6WUZ [DatabaseIdentifier:12191061] PDB:7D9P [DatabaseIdentifier:12191063] PDB:7D9Q [DatabaseIdentifier:12191051] PDB:7RB5 [DatabaseIdentifier:12191062] PDB:7XN1 [DatabaseIdentifier:12191050] PDB:8DT2 [DatabaseIdentifier:12191052] PDB:7RB6 [DatabaseIdentifier:12191060] PDB:7E3H [DatabaseIdentifier:12191036] PDB:4EY7 [DatabaseIdentifier:12191043] PDB:2X8B [DatabaseIdentifier:12191028] PDB:6O5S [DatabaseIdentifier:12191039] PDB:6WUY [DatabaseIdentifier:12191054] PDB:4M0E [DatabaseIdentifier:12191038] PDB:6WUV [DatabaseIdentifier:12191029] PDB:6O5R [DatabaseIdentifier:12191030] PDB:6NTG [DatabaseIdentifier:12191053] PDB:8DT7 [DatabaseIdentifier:12191035] PDB:6NTK [DatabaseIdentifier:12191042] PDB:7P1P [DatabaseIdentifier:12191034] PDB:4EY6 [DatabaseIdentifier:12191045] PDB:7RB7 [DatabaseIdentifier:12191027] PDB:6NTN [DatabaseIdentifier:12191056] PDB:4M0F [DatabaseIdentifier:12191046] PDB:5FPQ [DatabaseIdentifier:12191057] PDB:8DT5 [DatabaseIdentifier:12191032] PDB:4EY5 [DatabaseIdentifier:12191049] PDB:6NEA [DatabaseIdentifier:12191044] PDB:8AEN [DatabaseIdentifier:12191047] PDB:5HQ3 [DatabaseIdentifier:12191058] PDB:1B41 [DatabaseIdentifier:12191037] PDB:6WVC [DatabaseIdentifier:12191055] PDB:8DT4 [DatabaseIdentifier:12191041] PDB:8AEV [DatabaseIdentifier:12191048] PDB:7P1N [DatabaseIdentifier:12191033] PDB:6NTH [DatabaseIdentifier:12191059] PDB:7D9O [DatabaseIdentifier:12191031] PDB:4EY4 [DatabaseIdentifier:12191012] PDB:6O66 [DatabaseIdentifier:12190988] PDB:4BDT [DatabaseIdentifier:12191025] PDB:5FOQ [DatabaseIdentifier:12190998] PDB:6CQT [DatabaseIdentifier:12191015] PDB:6O5V [DatabaseIdentifier:12190997] PDB:6CQU [DatabaseIdentifier:12191006] PDB:6O52 [DatabaseIdentifier:12191017] PDB:6O69 [DatabaseIdentifier:12190994] PDB:6O4W [DatabaseIdentifier:12191024] PDB:6NTL [DatabaseIdentifier:12191019] PDB:7E3D [DatabaseIdentifier:12191008] PDB:5HF6 [DatabaseIdentifier:12190995] PDB:6WV1 [DatabaseIdentifier:12191005] PDB:6CQZ [DatabaseIdentifier:12190990] PDB:6U34 [DatabaseIdentifier:12191021] PDB:9OMS [DatabaseIdentifier:12191013] PDB:3LII [DatabaseIdentifier:12190992] PDB:1VZJ [DatabaseIdentifier:12190989] PDB:6F25 [DatabaseIdentifier:12191014] PDB:6WVP [DatabaseIdentifier:12191003] PDB:6CQX [DatabaseIdentifier:12190996] PDB:4PQE [DatabaseIdentifier:12191009] PDB:5HF5 [DatabaseIdentifier:12191007] PDB:5HFA [DatabaseIdentifier:12191000] PDB:6CQV [DatabaseIdentifier:12191026] PDB:6NTO [DatabaseIdentifier:12191018] PDB:6WVQ [DatabaseIdentifier:11495361] ENSEMBL:ENSG00000087085 [DatabaseIdentifier:11603500] ENSEMBL:ENSP00000303211 [DatabaseIdentifier:11603498] ENSEMBL:ENSP00000414858 [DatabaseIdentifier:11603496] ENSEMBL:ENSP00000404865 [DatabaseIdentifier:11603497] ENSEMBL:ENSP00000241069 [DatabaseIdentifier:11603495] ENSEMBL:ENSP00000394976 [DatabaseIdentifier:11603499] ENSEMBL:ENSP00000403474 [DatabaseIdentifier:11726194] ENSEMBL:ENST00000411582 [DatabaseIdentifier:11726196] ENSEMBL:ENST00000419336 [DatabaseIdentifier:11726198] ENSEMBL:ENST00000428317 [DatabaseIdentifier:11726197] ENSEMBL:ENST00000412389 [DatabaseIdentifier:11726199] ENSEMBL:ENST00000241069 [DatabaseIdentifier:11726195] ENSEMBL:ENST00000302913 [DatabaseIdentifier:11779147] Guide to Pharmacology - Targets:2465 [DatabaseIdentifier:11789652] GeneCards:ACHE [DatabaseIdentifier:11805314] GlyGen:P22303 [DatabaseIdentifier:11829482] HMDB Protein:HMDBP00524 [DatabaseIdentifier:11842679] HPA:ENSG00000087085-ACHE [DatabaseIdentifier:12127272] OpenTargets:ENSG00000087085 [DatabaseIdentifier:12191002] PDB:6CQY [DatabaseIdentifier:12191016] PDB:6WVO [DatabaseIdentifier:12191011] PDB:5HF9 [DatabaseIdentifier:12190986] PDB:1F8U [DatabaseIdentifier:12190987] PDB:6U3P [DatabaseIdentifier:12191022] PDB:4EY8 [DatabaseIdentifier:12190993] PDB:6O4X [DatabaseIdentifier:12191023] PDB:6NTM [DatabaseIdentifier:12190999] PDB:6CQW [DatabaseIdentifier:12191010] PDB:5HF8 [DatabaseIdentifier:12191020] PDB:9OMT [DatabaseIdentifier:12190991] PDB:6U37 [DatabaseIdentifier:12191001] PDB:6ZWE
databaseName	UniProt
dbId	49498
description	recommendedName: fullName evidence="18"Acetylcholinesterase shortName: AChE ecNumber evidence="5"3.1.1.7
displayName	UniProt:P22303 ACHE
geneName	ACHE
identifier	P22303
isSequenceChanged	false
keyword	3D-structure Alternative splicing Blood group antigen Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Hydrolase Lipoprotein Membrane Neurotransmitter degradation Nucleus Proteomics identification Reference proteome Secreted Serine esterase Signal Synapse
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	ACHE
otherIdentifier	11733279_a_at 11733280_a_at 17060787 17060791 205377_PM_s_at 205377_s_at 205378_PM_s_at 205378_s_at 240280_PM_at 240280_at 3064356 3064357 3064358 3064359 3064360 3064362 3064363 3064364 3064365 3064366 3064367 3064369 3064370 3064371 3064372 3064373 3064374 3064375 3064376 3064377 3064378 3064379 3064380 3064381 35387_r_at 40249_at 43 67198_at 8141643 8141648 ADDON002502.hg A_24_P60845 GE82034 GO:0001507 GO:0001540 GO:0001919 GO:0002076 GO:0003990 GO:0004104 GO:0005515 GO:0005518 GO:0005576 GO:0005604 GO:0005615 GO:0005634 GO:0005794 GO:0005886 GO:0006581 GO:0007155 GO:0007399 GO:0007416 GO:0009986 GO:0016020 GO:0016192 GO:0016787 GO:0017171 GO:0030312 GO:0031012 GO:0031594 GO:0031623 GO:0032223 GO:0034330 GO:0042166 GO:0042802 GO:0042803 GO:0042982 GO:0043083 GO:0043236 GO:0045202 GO:0048471 GO:0048856 GO:0050714 GO:0052689 GO:0060041 GO:0095500 GO:0098552 GO:0120162 HMNXSV003013565 HMNXSV003053971 Hs.154495.0.S1_3p_a_at Hs.157779.0.A1_3p_at ILMN_1780485 ILMN_2333219 M55040_at PH_hs_0009299 PH_hs_0035082 S71129_at TC07001679.hg TC07001680.hg g7710111_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1524050] ACHE [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-372506] ACHE [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000087085] ENSEMBL:ENSG00000087085 ACHE [ReferenceDNASequence:12753261] UCSC:P22303 ACHE [ReferenceDNASequence:11361031] BioGPS Gene:43 ACHE [ReferenceDNASequence:11401820] COSMIC - genes:ACHE ACHE [ReferenceDNASequence:11416452] CTD Gene:43 ACHE [ReferenceDNASequence:11439218] dbSNP Gene:43 ACHE [ReferenceDNASequence:11821309] HGNC:108 ACHE [ReferenceDNASequence:11900034] KEGG:hsa:43 ACHE [ReferenceDNASequence:11990820] Monarch:43 ACHE [ReferenceDNASequence:12074913] NCBI Gene:43 ACHE [ReferenceDNASequence:12112169] OMIM:100740 ACHE
referenceTranscript	[ReferenceRNASequence:12600878] RefSeq:NM_001302622.2 ACHE [ReferenceRNASequence:12600882] RefSeq:NM_001282449.2 ACHE [ReferenceRNASequence:12600877] RefSeq:NM_001302621.3 ACHE [ReferenceRNASequence:12600881] RefSeq:NM_001367915.1 ACHE [ReferenceRNASequence:12600879] RefSeq:NM_000665.5 ACHE [ReferenceRNASequence:12600880] RefSeq:NM_001367917.1 ACHE
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ACES_HUMAN A4D2E2 B7ZKZ0 D6W5X7 Q16169 Q29S23 Q2M324 Q504V3 Q53F46 Q86TM9 Q86YX9 Q9BXP7
sequenceLength	614
species	[Species:48887] Homo sapiens
stId	uniprot:P22303
url	http://purl.uniprot.org/uniprot/P22303

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-1524050] ACHE [plasma membrane] [EntityWithAccessionedSequence:R-HSA-372506] ACHE [extracellular region]
(interactor)	[UndirectedInteraction:11138385] UniProt:P63244 <-> UniProt:P22303 (IntAct) [UndirectedInteraction:11170239] UniProt:P22303 <-> UniProt:Q9Y215 (IntAct) [UndirectedInteraction:11170241] UniProt:P22303 <-> UniProt:P06733 (IntAct)

Cite Us!