Reactome | UniProt:P22139 RPB10

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UniProt:P22139 RPB10 Show undefined attributes

chain	chain:1-70
checksum	E1F5733E8F466BE0
comment	FUNCTION DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.SUBUNIT Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.INTERACTION Present with 5300 molecules/cell in log phase SD medium.SIMILARITY Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
crossReference	[DatabaseIdentifier:12163307] PDB:6RRD [DatabaseIdentifier:12421145] RefSeq:NP_014853.3 [DatabaseIdentifier:12248848] PRO:P22139 [DatabaseIdentifier:12149409] PDB:4A3G [DatabaseIdentifier:12145623] PDB:7O4J [DatabaseIdentifier:12149413] PDB:5C4J [DatabaseIdentifier:12149414] PDB:4A3L [DatabaseIdentifier:12145635] PDB:5SVA [DatabaseIdentifier:12149411] PDB:4A3J [DatabaseIdentifier:12138670] PDB:6EU0 [DatabaseIdentifier:12145626] PDB:7O4I [DatabaseIdentifier:12149396] PDB:5C4A [DatabaseIdentifier:12138671] PDB:6EU3 [DatabaseIdentifier:12145627] PDB:8UOT [DatabaseIdentifier:12149399] PDB:4A3D [DatabaseIdentifier:12149395] PDB:3H3V [DatabaseIdentifier:12145618] PDB:7O75 [DatabaseIdentifier:12149398] PDB:4A3C [DatabaseIdentifier:12138673] PDB:6EU2 [DatabaseIdentifier:12149426] PDB:6BQF [DatabaseIdentifier:12163347] PDB:9G24 [DatabaseIdentifier:12149392] PDB:5FZ5 [DatabaseIdentifier:12149390] PDB:5IP9 [DatabaseIdentifier:12149425] PDB:3GTO [DatabaseIdentifier:12163351] PDB:9G23 [DatabaseIdentifier:12145631] PDB:8UOQ [DatabaseIdentifier:12163345] PDB:9G27 [DatabaseIdentifier:12149400] PDB:4A3E [DatabaseIdentifier:12149422] PDB:3GTK [DatabaseIdentifier:12149397] PDB:4A3B [DatabaseIdentifier:12163336] PDB:6HKO [DatabaseIdentifier:12163338] PDB:6HLR [DatabaseIdentifier:12149408] PDB:4A3F [DatabaseIdentifier:12138685] PDB:5FJA [DatabaseIdentifier:12138687] PDB:5FJ9 [DatabaseIdentifier:12149402] PDB:9BW0 [DatabaseIdentifier:12149393] PDB:5FYW [DatabaseIdentifier:12138690] PDB:8BWS [DatabaseIdentifier:12149430] PDB:3GTG [DatabaseIdentifier:12145614] PDB:7O72 [DatabaseIdentifier:12149428] PDB:2E2I [DatabaseIdentifier:12145619] PDB:7O73 [DatabaseIdentifier:12149389] PDB:5IP7 [DatabaseIdentifier:12149419] PDB:3RZO [DatabaseIdentifier:12149427] PDB:2E2J [DatabaseIdentifier:12149403] PDB:5C3E [DatabaseIdentifier:12163342] PDB:6RQT [DatabaseIdentifier:12149410] PDB:4A3I [DatabaseIdentifier:12149417] PDB:3GTP [DatabaseIdentifier:12149391] PDB:3I4N [DatabaseIdentifier:12149388] PDB:6O6C [DatabaseIdentifier:12163344] PDB:9G1V [DatabaseIdentifier:12149407] PDB:5C4X [DatabaseIdentifier:12149424] PDB:3GTM [DatabaseIdentifier:12149429] PDB:2E2H [DatabaseIdentifier:12149406] PDB:9BVT [DatabaseIdentifier:12149404] PDB:6GYK [DatabaseIdentifier:12149420] PDB:3RZD [DatabaseIdentifier:12138667] PDB:5FJ8 [DatabaseIdentifier:12149412] PDB:4A3K [DatabaseIdentifier:12149405] PDB:6GYL [DatabaseIdentifier:12163343] PDB:9G26 [DatabaseIdentifier:12149401] PDB:5C44 [DatabaseIdentifier:12149423] PDB:3GTL [DatabaseIdentifier:12163341] PDB:9G2C [DatabaseIdentifier:12163339] PDB:6HLQ [DatabaseIdentifier:12145636] PDB:6GYM [DatabaseIdentifier:12138669] PDB:6EU1 [DatabaseIdentifier:12149394] PDB:3I4M [DatabaseIdentifier:12149415] PDB:4A3M [DatabaseIdentifier:12138682] PDB:6TUT [DatabaseIdentifier:12163346] PDB:6RQH [DatabaseIdentifier:12163350] PDB:9G29 [DatabaseIdentifier:12163348] PDB:6RQL [DatabaseIdentifier:12163349] PDB:9G1X [DatabaseIdentifier:12149418] PDB:3GTQ [DatabaseIdentifier:12149421] PDB:3GTJ [DatabaseIdentifier:12163340] PDB:9G2B [DatabaseIdentifier:12163337] PDB:6HLS [DatabaseIdentifier:12149416] PDB:2VUM [DatabaseIdentifier:12138672] PDB:6F41 [DatabaseIdentifier:12149370] PDB:6BLO [DatabaseIdentifier:12149334] PDB:8JCH [DatabaseIdentifier:12145630] PDB:8UMI [DatabaseIdentifier:12149373] PDB:8UKU [DatabaseIdentifier:12163328] PDB:4C3H [DatabaseIdentifier:12149333] PDB:3J1N [DatabaseIdentifier:12149380] PDB:7RIY [DatabaseIdentifier:12149339] PDB:3HOX [DatabaseIdentifier:12138674] PDB:6F40 [DatabaseIdentifier:12149338] PDB:3HOW [DatabaseIdentifier:12149366] PDB:4BBS [DatabaseIdentifier:12149384] PDB:1NT9 [DatabaseIdentifier:12149345] PDB:6I84 [DatabaseIdentifier:12163320] PDB:5W5Y [DatabaseIdentifier:12163319] PDB:5W66 [DatabaseIdentifier:12149354] PDB:1R9S [DatabaseIdentifier:12149342] PDB:6UQ0 [DatabaseIdentifier:12163330] PDB:4C3J [DatabaseIdentifier:12149351] PDB:1WCM [DatabaseIdentifier:12163318] PDB:5W64 [DatabaseIdentifier:12149346] PDB:3PO2 [DatabaseIdentifier:12163315] PDB:6H67 [DatabaseIdentifier:12149368] PDB:6BLP [DatabaseIdentifier:12163313] PDB:5G5L [DatabaseIdentifier:12149374] PDB:8UKR [DatabaseIdentifier:12163314] PDB:4YM7 [DatabaseIdentifier:12138681] PDB:6CNF [DatabaseIdentifier:12149330] PDB:3S1Q [DatabaseIdentifier:12149387] PDB:3K7A [DatabaseIdentifier:12149375] PDB:8UKS [DatabaseIdentifier:12149329] PDB:7MKA [DatabaseIdentifier:12149352] PDB:5VVS [DatabaseIdentifier:12149343] PDB:3FKI [DatabaseIdentifier:12140080] PDB:8RAM [DatabaseIdentifier:12149335] PDB:5W4U [DatabaseIdentifier:12149378] PDB:2R92 [DatabaseIdentifier:12163332] PDB:5M5W [DatabaseIdentifier:12149364] PDB:7RIM [DatabaseIdentifier:12163322] PDB:5N5Z [DatabaseIdentifier:12138677] PDB:6CND [DatabaseIdentifier:12149371] PDB:8UKQ [DatabaseIdentifier:12163317] PDB:5W65 [DatabaseIdentifier:12149350] PDB:1I6H [DatabaseIdentifier:12149348] PDB:2B63 [DatabaseIdentifier:12163335] PDB:6TPS [DatabaseIdentifier:12149361] PDB:6UPX [DatabaseIdentifier:12149355] PDB:6UPZ [DatabaseIdentifier:12138679] PDB:6CNC [DatabaseIdentifier:12163334] PDB:5M64 [DatabaseIdentifier:12149372] PDB:8UKT [DatabaseIdentifier:12149344] PDB:8K5P [DatabaseIdentifier:12149341] PDB:3HOY [DatabaseIdentifier:12149362] PDB:1Y77 [DatabaseIdentifier:12149326] PDB:8TVQ [DatabaseIdentifier:12163325] PDB:5N61 [DatabaseIdentifier:12149376] PDB:5U5Q [DatabaseIdentifier:12163329] PDB:4C3I [DatabaseIdentifier:12149358] PDB:3HOZ [DatabaseIdentifier:12149382] PDB:2B8K [DatabaseIdentifier:12149347] PDB:3PO3 [DatabaseIdentifier:12163321] PDB:5N5Y [DatabaseIdentifier:12149327] PDB:3S2H [DatabaseIdentifier:12163326] PDB:4C2M [DatabaseIdentifier:12149357] PDB:2YU9 [DatabaseIdentifier:12145629] PDB:8UMH [DatabaseIdentifier:12163333] PDB:5M5Y [DatabaseIdentifier:12149356] PDB:6UPY [DatabaseIdentifier:12143816] PDB:5VVR [DatabaseIdentifier:12163324] PDB:5M3M [DatabaseIdentifier:12149377] PDB:2R93 [DatabaseIdentifier:12163323] PDB:5N60 [DatabaseIdentifier:12149328] PDB:1R5U [DatabaseIdentifier:12149340] PDB:6UQ1 [DatabaseIdentifier:12163316] PDB:6H68 [DatabaseIdentifier:12149360] PDB:6UQ2 [DatabaseIdentifier:12145632] PDB:8CEN [DatabaseIdentifier:12145634] PDB:8CEO [DatabaseIdentifier:12149337] PDB:3HOV [DatabaseIdentifier:12149331] PDB:3S1R [DatabaseIdentifier:12138676] PDB:6CNB [DatabaseIdentifier:12149383] PDB:2R7Z [DatabaseIdentifier:12149332] PDB:7MK9 [DatabaseIdentifier:12149363] PDB:3QT1 [DatabaseIdentifier:12149386] PDB:7RIQ [DatabaseIdentifier:12149381] PDB:7RIW [DatabaseIdentifier:12149365] PDB:4BBR [DatabaseIdentifier:12149359] PDB:6UQ3 [DatabaseIdentifier:12149367] PDB:6BM2 [DatabaseIdentifier:12149385] PDB:7RIP [DatabaseIdentifier:12149369] PDB:6BM4 [DatabaseIdentifier:12149379] PDB:7RIX [DatabaseIdentifier:12138668] PDB:6F44 [DatabaseIdentifier:12149353] PDB:1R9T [DatabaseIdentifier:12138675] PDB:6F42 [DatabaseIdentifier:12149336] PDB:3HOU [DatabaseIdentifier:12140074] PDB:8RAP [DatabaseIdentifier:12163331] PDB:5M5X [DatabaseIdentifier:12163327] PDB:5M3F [DatabaseIdentifier:12149349] PDB:9JA1 [DatabaseIdentifier:12145620] PDB:5OQM [DatabaseIdentifier:12145611] PDB:7ML2 [DatabaseIdentifier:12149291] PDB:7KEE [DatabaseIdentifier:12145613] PDB:7ZSB [DatabaseIdentifier:12149296] PDB:1Y1V [DatabaseIdentifier:12163310] PDB:6RUO [DatabaseIdentifier:12149321] PDB:5W51 [DatabaseIdentifier:12149288] PDB:1Y1Y [DatabaseIdentifier:12149286] PDB:5OT2 [DatabaseIdentifier:12149289] PDB:7KED [DatabaseIdentifier:12149277] PDB:4X6A [DatabaseIdentifier:12149308] PDB:3S15 [DatabaseIdentifier:12149313] PDB:7NKX [DatabaseIdentifier:12163308] PDB:5OA1 [DatabaseIdentifier:12149285] PDB:3CQZ [DatabaseIdentifier:12149257] PDB:2NVQ [DatabaseIdentifier:12149260] PDB:2NVY [DatabaseIdentifier:12149318] PDB:1I50 [DatabaseIdentifier:12149300] PDB:3S1M [DatabaseIdentifier:12149295] PDB:1Y1W [DatabaseIdentifier:12143834] PDB:7UIO [DatabaseIdentifier:12149305] PDB:9N5C [DatabaseIdentifier:12145622] PDB:7ZS9 [DatabaseIdentifier:12138686] PDB:7Z2Z [DatabaseIdentifier:12145621] PDB:5FMF [DatabaseIdentifier:12149265] PDB:4BXX [DatabaseIdentifier:12138688] PDB:7Z30 [DatabaseIdentifier:12149282] PDB:2JA5 [DatabaseIdentifier:12145610] PDB:7ML4 [DatabaseIdentifier:12149272] PDB:1TWF [DatabaseIdentifier:12149309] PDB:9N5G [DatabaseIdentifier:12149298] PDB:1I3Q [DatabaseIdentifier:12149271] PDB:4Y7N [DatabaseIdentifier:12149261] PDB:4BXZ [DatabaseIdentifier:12149268] PDB:2NVZ [DatabaseIdentifier:12149324] PDB:3S2D [DatabaseIdentifier:12149312] PDB:3S17 [DatabaseIdentifier:12149262] PDB:2NVX [DatabaseIdentifier:12149266] PDB:4Y52 [DatabaseIdentifier:12149270] PDB:1TWG [DatabaseIdentifier:12149276] PDB:1TWA [DatabaseIdentifier:12149311] PDB:9N5F [DatabaseIdentifier:12149274] PDB:4V1N [DatabaseIdentifier:12149310] PDB:3S16 [DatabaseIdentifier:12149279] PDB:4V1O [DatabaseIdentifier:12149317] PDB:8TVS [DatabaseIdentifier:12149263] PDB:2NVT [DatabaseIdentifier:12149297] PDB:1SFO [DatabaseIdentifier:12149281] PDB:2JA6 [DatabaseIdentifier:12149314] PDB:9N5E [DatabaseIdentifier:12145606] PDB:7ML0 [DatabaseIdentifier:12163312] PDB:5LMX [DatabaseIdentifier:12149287] PDB:7UIF [DatabaseIdentifier:12149284] PDB:4A93 [DatabaseIdentifier:12145615] PDB:5OQJ [DatabaseIdentifier:12138666] PDB:7Z0H [DatabaseIdentifier:12149267] PDB:4BY1 [DatabaseIdentifier:11496461] ENSEMBL:YOR210W [DatabaseIdentifier:11604911] ENSEMBL:YOR210W [DatabaseIdentifier:11727610] ENSEMBL:YOR210W_mRNA [DatabaseIdentifier:12149259] PDB:1NIK [DatabaseIdentifier:12145607] PDB:7ML1 [DatabaseIdentifier:12149307] PDB:3S14 [DatabaseIdentifier:12163309] PDB:6RUI [DatabaseIdentifier:12149303] PDB:8TUG [DatabaseIdentifier:12149292] PDB:7KEF [DatabaseIdentifier:12138678] PDB:7Z1N [DatabaseIdentifier:12149306] PDB:9N5B [DatabaseIdentifier:12145617] PDB:7ZSA [DatabaseIdentifier:12149316] PDB:9N5D [DatabaseIdentifier:12149319] PDB:8TVX [DatabaseIdentifier:12149325] PDB:8TVP [DatabaseIdentifier:12138684] PDB:7Z1M [DatabaseIdentifier:12149299] PDB:1K83 [DatabaseIdentifier:12149322] PDB:8TVW [DatabaseIdentifier:12149301] PDB:3S1N [DatabaseIdentifier:12138689] PDB:7Z31 [DatabaseIdentifier:12149290] PDB:3M4O [DatabaseIdentifier:12143817] PDB:8TVY [DatabaseIdentifier:12149264] PDB:4BY7 [DatabaseIdentifier:12149269] PDB:1TWH [DatabaseIdentifier:12163311] PDB:6RWE [DatabaseIdentifier:12149304] PDB:3K1F [DatabaseIdentifier:12149275] PDB:1TWC [DatabaseIdentifier:12149302] PDB:1PQV [DatabaseIdentifier:12149258] PDB:7MEI [DatabaseIdentifier:12149315] PDB:7NKY [DatabaseIdentifier:12149278] PDB:2JA8 [DatabaseIdentifier:12149320] PDB:8TVV [DatabaseIdentifier:12149280] PDB:2JA7 [DatabaseIdentifier:12138683] PDB:7Z1L [DatabaseIdentifier:12149293] PDB:7UI9 [DatabaseIdentifier:12138680] PDB:7Z1O [DatabaseIdentifier:12149323] PDB:3J0K [DatabaseIdentifier:12149273] PDB:4V1M [DatabaseIdentifier:12149283] PDB:4X67 [DatabaseIdentifier:12149294] PDB:3M3Y
databaseName	UniProt
dbId	100508
description	recommendedName: DNA-directed RNA polymerases I, II, and III subunit RPABC5 shortName: RNA polymerases I, II, and III subunit ABC5 alternativeName: ABC10-beta alternativeName: ABC8 alternativeName: DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide
displayName	UniProt:P22139 RPB10
geneName	RPB10 YOR210W
identifier	P22139
isSequenceChanged	false
keyword	3D-structure Direct protein sequencing DNA-directed RNA polymerase Isopeptide bond Metal-binding Nucleus Reference proteome Ribosome biogenesis Transcription Ubl conjugation Zinc
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	RPB10
otherIdentifier	854385 GO:0000428 GO:0001054 GO:0001172 GO:0003674 GO:0003677 GO:0003899 GO:0003968 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005665 GO:0005666 GO:0005730 GO:0005736 GO:0006351 GO:0006352 GO:0006353 GO:0006354 GO:0006360 GO:0006361 GO:0006362 GO:0006363 GO:0006366 GO:0006367 GO:0006368 GO:0006383 GO:0006384 GO:0006386 GO:0008270 GO:0016740 GO:0016779 GO:0042254 GO:0042790 GO:0042797 GO:0043167 GO:0046872
physicalEntity	[EntityWithAccessionedSequence:R-SCE-83715] POLR2L [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-111837] RPBX_YEAST [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11362022] BioGPS Gene:854385 RPB10 [ReferenceDNASequence:12753854] UCSC:P22139 RPB10 [ReferenceDNASequence:11900916] KEGG:sce:YOR210W RPB10 [ReferenceDNASequence:11991811] Monarch:854385 RPB10 [ReferenceDNASequence:12075904] NCBI Gene:854385 RPB10
referenceTranscript	[ReferenceRNASequence:12602733] RefSeq:NM_001183629.3 RPB10
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RPAB5_YEAST D6W2R6
sequenceLength	70
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P22139
url	http://purl.uniprot.org/uniprot/P22139

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-83715] POLR2L [nucleoplasm] [EntityWithAccessionedSequence:R-SCE-111837] RPBX_YEAST [nucleoplasm]
(interactor)	[UndirectedInteraction:11190455] UniProt:Q00684 <-> UniProt:P22139 (IntAct)

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