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FUNCTION The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:25412659, PubMed:27007846, PubMed:33795473). TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (PubMed:33795473). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (PubMed:25412659, PubMed:8625415). Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (PubMed:25412659). Phosphorylates GTF2A1 and GTF2F1 on Ser residues (PubMed:25412659). Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)COFACTOR Autophosphorylates on Ser residues (PubMed:8625415). Inhibited by retinoblastoma tumor suppressor protein, RB1 (PubMed:9858607). Binding to TAF7 or CIITA inhibits the histone acetyltransferase activity (PubMed:11592977, PubMed:22711989).SUBUNIT Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:7680771). Interacts with TAF7; the interaction is direct (PubMed:11592977, PubMed:25412659). TAF1, when part of the TFIID complex, interacts with C-terminus of TP53 (PubMed:15053879). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). RB1 interacts with the N-terminal domain of TAF1 (PubMed:9858607). Interacts with ASF1A and ASF1B (PubMed:10759893, PubMed:12093919, PubMed:12842904). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (PubMed:22464331).SUBUNIT (Microbial infection) Interacts with SV40 Large T antigen.SUBUNIT (Microbial infection) Interacts with herpes simplex virus 1 ICP4.INTERACTION the TAF1/DYT3 multiple transcript system is composed of 38 evolutionary conserved exons plus 5 downstream exons referred to as exons d1-d5 that are primate-specific. Multiple highly polymorphic variants can be generated by splicing exons d3 and d4 to various combinations of exons 1-37.DOMAIN The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). The second domain also recognizes and binds histones that are butyrylated and crotonylated (PubMed:26365797).PTM Phosphorylated by casein kinase II in vitro.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable).MISCELLANEOUS May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable).MISCELLANEOUS May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable).MISCELLANEOUS May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable).MISCELLANEOUS May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable).MISCELLANEOUS May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable).MISCELLANEOUS Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable).MISCELLANEOUS May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS Only detected in brain, highest expression in the caudate nucleus.SIMILARITY Belongs to the TAF1 family.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal and C-terminal part.
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