Reactome | UniProt:P20711 DDC

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UniProt:P20711 DDC Show undefined attributes

chain	chain:1-480
checksum	0A2CFF9A39BDE298
comment	FUNCTION Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.CATALYTIC ACTIVITY L-dopa + H(+) = dopamine + CO2CATALYTIC ACTIVITY 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2COFACTOR Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.SUBUNIT Homodimer.INTERACTION High expression in kidney.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the group II decarboxylase family.ONLINE INFORMATION Aromatic L-amino-acid decarboxylase entry
crossReference	[DatabaseIdentifier:12338299] RefSeq:NP_000781.2 [DatabaseIdentifier:12814540] ZINC target:P20711 [DatabaseIdentifier:12811227] ZINC - Substances:DDC_HUMAN [DatabaseIdentifier:12338304] RefSeq:XP_047275887.1 [DatabaseIdentifier:12338305] RefSeq:NP_001229815.2 [DatabaseIdentifier:11459150] ENSEMBL:ENSG00000132437 [DatabaseIdentifier:11551306] ENSEMBL:ENSP00000370371 [DatabaseIdentifier:11551305] ENSEMBL:ENSP00000484104 [DatabaseIdentifier:11551308] ENSEMBL:ENSP00000395069 [DatabaseIdentifier:11551309] ENSEMBL:ENSP00000350616 [DatabaseIdentifier:11551310] ENSEMBL:ENSP00000399184 [DatabaseIdentifier:11551307] ENSEMBL:ENSP00000403644 [DatabaseIdentifier:11674008] ENSEMBL:ENST00000431062 [DatabaseIdentifier:11674004] ENSEMBL:ENST00000426377 [DatabaseIdentifier:11674009] ENSEMBL:ENST00000380984 [DatabaseIdentifier:11674007] ENSEMBL:ENST00000615193 [DatabaseIdentifier:11674005] ENSEMBL:ENST00000444124 [DatabaseIdentifier:11674006] ENSEMBL:ENST00000357936 [DatabaseIdentifier:11779208] Guide to Pharmacology - Targets:1271 [DatabaseIdentifier:11792812] GeneCards:DDC [DatabaseIdentifier:11829541] HMDB Protein:HMDBP00278 [DatabaseIdentifier:11845802] HPA:ENSG00000132437-DDC [DatabaseIdentifier:12130452] OpenTargets:ENSG00000132437 [DatabaseIdentifier:12135176] Orphanet:DDC [DatabaseIdentifier:12215296] PDB:3RBF [DatabaseIdentifier:12215297] PDB:3RCH [DatabaseIdentifier:12215293] PDB:3RBL [DatabaseIdentifier:12215298] PDB:8ORA [DatabaseIdentifier:12215295] PDB:9GNS [DatabaseIdentifier:12215294] PDB:8OR9 [DatabaseIdentifier:12215299] PDB:9HRI [DatabaseIdentifier:12215300] PDB:9HRH [DatabaseIdentifier:12252657] PRO:P20711 [DatabaseIdentifier:12290656] Pharos - Targets:P20711 [DatabaseIdentifier:12338303] RefSeq:NP_001229819.2 [DatabaseIdentifier:12338301] RefSeq:NP_001229817.2 [DatabaseIdentifier:12338300] RefSeq:NP_001229816.2 [DatabaseIdentifier:12338298] RefSeq:NP_001076440.2 [DatabaseIdentifier:12338302] RefSeq:NP_001229818.2
databaseName	UniProt
dbId	53494
description	recommendedName: fullName evidence="16"Aromatic-L-amino-acid decarboxylase shortName evidence="16"AADC ecNumber: 4.1.1.28 alternativeName: fullName evidence="15"DOPA decarboxylase shortName evidence="15"DDC
displayName	UniProt:P20711 DDC
geneName	DDC AADC
identifier	P20711
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Catecholamine biosynthesis Decarboxylase Disease variant Lyase Proteomics identification Pyridoxal phosphate Reference proteome Repeat
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	DDC
otherIdentifier	11722740_a_at 11722741_a_at 11722742_x_at 1644 17057736 205311_PM_at 205311_at 214347_PM_s_at 214347_s_at 236774_PM_at 236774_at 236775_PM_s_at 236775_s_at 3050389 3050390 3050391 3050392 3050393 3050396 3050407 3050408 3050413 3050414 3050416 3050420 3050426 3050430 3050431 3050432 3050438 3050439 3050440 3050447 3050448 3050449 3050450 3050453 3050454 3050455 40201_at 8139640 82807_at A_23_P145644 A_33_P3355004 GE79278 GO:0001822 GO:0004058 GO:0005515 GO:0005737 GO:0005829 GO:0006520 GO:0006576 GO:0006584 GO:0009636 GO:0010467 GO:0016829 GO:0016830 GO:0016831 GO:0019752 GO:0019899 GO:0030170 GO:0036467 GO:0036468 GO:0042401 GO:0042416 GO:0042423 GO:0042427 GO:0048856 GO:0070062 HMNXSV003002764 HMNXSV003003319 HMNXSV003054865 Hs.145547.0.A1_3p_at Hs.150403.1.S1_3p_a_at Hs.150403.1.S1_3p_x_at ILMN_2228463 M76180_at PH_hs_0017340 PH_hs_0033187 TC07001373.hg g4503280_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-209810] PXLP-DDC [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000132437] ENSEMBL:ENSG00000132437 DDC [ReferenceDNASequence:12730448] UCSC:P20711 DDC [ReferenceDNASequence:11323836] BioGPS Gene:1644 DDC [ReferenceDNASequence:11398379] COSMIC - genes:DDC DDC [ReferenceDNASequence:11421101] CTD Gene:1644 DDC [ReferenceDNASequence:11435188] dbSNP Gene:1644 DDC [ReferenceDNASequence:11824497] HGNC:2719 DDC [ReferenceDNASequence:11866364] KEGG:hsa:1644 DDC [ReferenceDNASequence:11953625] Monarch:1644 DDC [ReferenceDNASequence:12037718] NCBI Gene:1644 DDC [ReferenceDNASequence:12115013] OMIM:107930 DDC
referenceTranscript	[ReferenceRNASequence:12520189] RefSeq:XM_047419931.1 DDC [ReferenceRNASequence:12520191] RefSeq:NM_001242890.2 DDC [ReferenceRNASequence:12520186] RefSeq:NM_001242888.2 DDC [ReferenceRNASequence:12520187] RefSeq:NM_001242887.2 DDC [ReferenceRNASequence:12520185] RefSeq:NM_001082971.2 DDC [ReferenceRNASequence:12520190] RefSeq:NM_000790.4 DDC [ReferenceRNASequence:12520188] RefSeq:NM_001242889.2 DDC [ReferenceRNASequence:12520184] RefSeq:NM_001242886.2 DDC
schemaClass	ReferenceGeneProduct
secondaryIdentifier	DDC_HUMAN C9IYA0 E7ER62 E7EU95 Q16723 Q5W5T9 Q75MJ6
sequenceLength	480
species	[Species:48887] Homo sapiens
stId	uniprot:P20711
url	http://purl.uniprot.org/uniprot/P20711

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-209810] PXLP-DDC [cytosol]
(referenceSequence)	[ModifiedResidue:556845] N6-pyridoxal phosphate-L-lysine at 303
(interactor)	[UndirectedInteraction:11268603] UniProt:P10275 <-> UniProt:P20711 (IntAct)

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