Reactome | UniProt:P20434 RPB5

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UniProt:P20434 RPB5 Show undefined attributes

chain	chain:1-215
checksum	2A15F7114D69D829
comment	FUNCTION DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerase complexes are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.SUBUNIT Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.INTERACTION Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
crossReference	[DatabaseIdentifier:12149288] PDB:1Y1Y [DatabaseIdentifier:12342921] RefSeq:NP_009712.1 [DatabaseIdentifier:12254591] PRO:P20434 [DatabaseIdentifier:12149420] PDB:3RZD [DatabaseIdentifier:12149421] PDB:3GTJ [DatabaseIdentifier:12149423] PDB:3GTL [DatabaseIdentifier:12149429] PDB:2E2H [DatabaseIdentifier:12149424] PDB:3GTM [DatabaseIdentifier:12149427] PDB:2E2J [DatabaseIdentifier:12149426] PDB:6BQF [DatabaseIdentifier:12149430] PDB:3GTG [DatabaseIdentifier:12149428] PDB:2E2I [DatabaseIdentifier:12149425] PDB:3GTO [DatabaseIdentifier:12163350] PDB:9G29 [DatabaseIdentifier:12149422] PDB:3GTK [DatabaseIdentifier:12145635] PDB:5SVA [DatabaseIdentifier:12163351] PDB:9G23 [DatabaseIdentifier:12149412] PDB:4A3K [DatabaseIdentifier:12149394] PDB:3I4M [DatabaseIdentifier:12149409] PDB:4A3G [DatabaseIdentifier:12163340] PDB:9G2B [DatabaseIdentifier:12163334] PDB:5M64 [DatabaseIdentifier:12149410] PDB:4A3I [DatabaseIdentifier:12145629] PDB:8UMH [DatabaseIdentifier:12149374] PDB:8UKR [DatabaseIdentifier:12149393] PDB:5FYW [DatabaseIdentifier:12138673] PDB:6EU2 [DatabaseIdentifier:12149419] PDB:3RZO [DatabaseIdentifier:12149405] PDB:6GYL [DatabaseIdentifier:12149373] PDB:8UKU [DatabaseIdentifier:12149400] PDB:4A3E [DatabaseIdentifier:12138690] PDB:8BWS [DatabaseIdentifier:12149396] PDB:5C4A [DatabaseIdentifier:12149380] PDB:7RIY [DatabaseIdentifier:12138668] PDB:6F44 [DatabaseIdentifier:12145618] PDB:7O75 [DatabaseIdentifier:12149403] PDB:5C3E [DatabaseIdentifier:12163338] PDB:6HLR [DatabaseIdentifier:12163329] PDB:4C3I [DatabaseIdentifier:12149404] PDB:6GYK [DatabaseIdentifier:12149415] PDB:4A3M [DatabaseIdentifier:12163348] PDB:6RQL [DatabaseIdentifier:12163330] PDB:4C3J [DatabaseIdentifier:12163339] PDB:6HLQ [DatabaseIdentifier:12138670] PDB:6EU0 [DatabaseIdentifier:12149387] PDB:3K7A [DatabaseIdentifier:12145623] PDB:7O4J [DatabaseIdentifier:12145619] PDB:7O73 [DatabaseIdentifier:12138669] PDB:6EU1 [DatabaseIdentifier:12149390] PDB:5IP9 [DatabaseIdentifier:12163333] PDB:5M5Y [DatabaseIdentifier:12149417] PDB:3GTP [DatabaseIdentifier:12149395] PDB:3H3V [DatabaseIdentifier:12163342] PDB:6RQT [DatabaseIdentifier:12149418] PDB:3GTQ [DatabaseIdentifier:12149388] PDB:6O6C [DatabaseIdentifier:12163331] PDB:5M5X [DatabaseIdentifier:12149372] PDB:8UKT [DatabaseIdentifier:12138675] PDB:6F42 [DatabaseIdentifier:12145614] PDB:7O72 [DatabaseIdentifier:12149376] PDB:5U5Q [DatabaseIdentifier:12145631] PDB:8UOQ [DatabaseIdentifier:12149392] PDB:5FZ5 [DatabaseIdentifier:12149369] PDB:6BM4 [DatabaseIdentifier:12149391] PDB:3I4N [DatabaseIdentifier:12163335] PDB:6TPS [DatabaseIdentifier:12149399] PDB:4A3D [DatabaseIdentifier:12145627] PDB:8UOT [DatabaseIdentifier:12138672] PDB:6F41 [DatabaseIdentifier:12138687] PDB:5FJ9 [DatabaseIdentifier:12149389] PDB:5IP7 [DatabaseIdentifier:12163347] PDB:9G24 [DatabaseIdentifier:12149398] PDB:4A3C [DatabaseIdentifier:12149416] PDB:2VUM [DatabaseIdentifier:12149386] PDB:7RIQ [DatabaseIdentifier:12138681] PDB:6CNF [DatabaseIdentifier:12138676] PDB:6CNB [DatabaseIdentifier:12149411] PDB:4A3J [DatabaseIdentifier:12163349] PDB:9G1X [DatabaseIdentifier:12138685] PDB:5FJA [DatabaseIdentifier:12149384] PDB:1NT9 [DatabaseIdentifier:12149408] PDB:4A3F [DatabaseIdentifier:12149385] PDB:7RIP [DatabaseIdentifier:12149381] PDB:7RIW [DatabaseIdentifier:12138677] PDB:6CND [DatabaseIdentifier:12145626] PDB:7O4I [DatabaseIdentifier:12138682] PDB:6TUT [DatabaseIdentifier:12163344] PDB:9G1V [DatabaseIdentifier:12149414] PDB:4A3L [DatabaseIdentifier:12138674] PDB:6F40 [DatabaseIdentifier:12163343] PDB:9G26 [DatabaseIdentifier:12149406] PDB:9BVT [DatabaseIdentifier:12149378] PDB:2R92 [DatabaseIdentifier:12163337] PDB:6HLS [DatabaseIdentifier:12163341] PDB:9G2C [DatabaseIdentifier:12163332] PDB:5M5W [DatabaseIdentifier:12163328] PDB:4C3H [DatabaseIdentifier:12149407] PDB:5C4X [DatabaseIdentifier:12138671] PDB:6EU3 [DatabaseIdentifier:12149413] PDB:5C4J [DatabaseIdentifier:12149379] PDB:7RIX [DatabaseIdentifier:12149371] PDB:8UKQ [DatabaseIdentifier:12149375] PDB:8UKS [DatabaseIdentifier:12145636] PDB:6GYM [DatabaseIdentifier:12163336] PDB:6HKO [DatabaseIdentifier:12149377] PDB:2R93 [DatabaseIdentifier:12163346] PDB:6RQH [DatabaseIdentifier:12149397] PDB:4A3B [DatabaseIdentifier:12149402] PDB:9BW0 [DatabaseIdentifier:12145630] PDB:8UMI [DatabaseIdentifier:12149382] PDB:2B8K [DatabaseIdentifier:12138667] PDB:5FJ8 [DatabaseIdentifier:12138679] PDB:6CNC [DatabaseIdentifier:12149401] PDB:5C44 [DatabaseIdentifier:12149383] PDB:2R7Z [DatabaseIdentifier:12163345] PDB:9G27 [DatabaseIdentifier:12149370] PDB:6BLO [DatabaseIdentifier:12163321] PDB:5N5Y [DatabaseIdentifier:12149343] PDB:3FKI [DatabaseIdentifier:12149323] PDB:3J0K [DatabaseIdentifier:12149351] PDB:1WCM [DatabaseIdentifier:12140080] PDB:8RAM [DatabaseIdentifier:12149346] PDB:3PO2 [DatabaseIdentifier:12145632] PDB:8CEN [DatabaseIdentifier:12140074] PDB:8RAP [DatabaseIdentifier:12149349] PDB:9JA1 [DatabaseIdentifier:12149363] PDB:3QT1 [DatabaseIdentifier:12149347] PDB:3PO3 [DatabaseIdentifier:12149340] PDB:6UQ1 [DatabaseIdentifier:12138689] PDB:7Z31 [DatabaseIdentifier:12149357] PDB:2YU9 [DatabaseIdentifier:12149366] PDB:4BBS [DatabaseIdentifier:12149309] PDB:9N5G [DatabaseIdentifier:12149331] PDB:3S1R [DatabaseIdentifier:12163311] PDB:6RWE [DatabaseIdentifier:12149333] PDB:3J1N [DatabaseIdentifier:12149322] PDB:8TVW [DatabaseIdentifier:12163327] PDB:5M3F [DatabaseIdentifier:12149344] PDB:8K5P [DatabaseIdentifier:12149301] PDB:3S1N [DatabaseIdentifier:12149325] PDB:8TVP [DatabaseIdentifier:12149355] PDB:6UPZ [DatabaseIdentifier:12163312] PDB:5LMX [DatabaseIdentifier:12149353] PDB:1R9T [DatabaseIdentifier:12149360] PDB:6UQ2 [DatabaseIdentifier:12163323] PDB:5N60 [DatabaseIdentifier:12163317] PDB:5W65 [DatabaseIdentifier:12149321] PDB:5W51 [DatabaseIdentifier:12163326] PDB:4C2M [DatabaseIdentifier:12149358] PDB:3HOZ [DatabaseIdentifier:12149327] PDB:3S2H [DatabaseIdentifier:12163315] PDB:6H67 [DatabaseIdentifier:12149302] PDB:1PQV [DatabaseIdentifier:12149300] PDB:3S1M [DatabaseIdentifier:12145607] PDB:7ML1 [DatabaseIdentifier:12149336] PDB:3HOU [DatabaseIdentifier:12149339] PDB:3HOX [DatabaseIdentifier:12149361] PDB:6UPX [DatabaseIdentifier:12149324] PDB:3S2D [DatabaseIdentifier:12143816] PDB:5VVR [DatabaseIdentifier:12163318] PDB:5W64 [DatabaseIdentifier:12149320] PDB:8TVV [DatabaseIdentifier:12149337] PDB:3HOV [DatabaseIdentifier:12145611] PDB:7ML2 [DatabaseIdentifier:12143817] PDB:8TVY [DatabaseIdentifier:12149303] PDB:8TUG [DatabaseIdentifier:12149359] PDB:6UQ3 [DatabaseIdentifier:12149318] PDB:1I50 [DatabaseIdentifier:12143834] PDB:7UIO [DatabaseIdentifier:12149326] PDB:8TVQ [DatabaseIdentifier:12149368] PDB:6BLP [DatabaseIdentifier:12149338] PDB:3HOW [DatabaseIdentifier:12163322] PDB:5N5Z [DatabaseIdentifier:12149332] PDB:7MK9 [DatabaseIdentifier:12149305] PDB:9N5C [DatabaseIdentifier:12149354] PDB:1R9S [DatabaseIdentifier:12149334] PDB:8JCH [DatabaseIdentifier:12149306] PDB:9N5B [DatabaseIdentifier:12149342] PDB:6UQ0 [DatabaseIdentifier:12149341] PDB:3HOY [DatabaseIdentifier:12138686] PDB:7Z2Z [DatabaseIdentifier:12149315] PDB:7NKY [DatabaseIdentifier:12149314] PDB:9N5E [DatabaseIdentifier:12163325] PDB:5N61 [DatabaseIdentifier:12149362] PDB:1Y77 [DatabaseIdentifier:12149365] PDB:4BBR [DatabaseIdentifier:12149313] PDB:7NKX [DatabaseIdentifier:12149317] PDB:8TVS [DatabaseIdentifier:12149335] PDB:5W4U [DatabaseIdentifier:12138688] PDB:7Z30 [DatabaseIdentifier:12149319] PDB:8TVX [DatabaseIdentifier:12149364] PDB:7RIM [DatabaseIdentifier:12149350] PDB:1I6H [DatabaseIdentifier:12149356] PDB:6UPY [DatabaseIdentifier:12163314] PDB:4YM7 [DatabaseIdentifier:12149307] PDB:3S14 [DatabaseIdentifier:12149345] PDB:6I84 [DatabaseIdentifier:12149316] PDB:9N5D [DatabaseIdentifier:12145634] PDB:8CEO [DatabaseIdentifier:12149348] PDB:2B63 [DatabaseIdentifier:12163324] PDB:5M3M [DatabaseIdentifier:12149329] PDB:7MKA [DatabaseIdentifier:12163319] PDB:5W66 [DatabaseIdentifier:12149312] PDB:3S17 [DatabaseIdentifier:12163320] PDB:5W5Y [DatabaseIdentifier:12149311] PDB:9N5F [DatabaseIdentifier:12149367] PDB:6BM2 [DatabaseIdentifier:12145610] PDB:7ML4 [DatabaseIdentifier:12163316] PDB:6H68 [DatabaseIdentifier:12149330] PDB:3S1Q [DatabaseIdentifier:12149310] PDB:3S16 [DatabaseIdentifier:12149308] PDB:3S15 [DatabaseIdentifier:12149352] PDB:5VVS [DatabaseIdentifier:12163313] PDB:5G5L [DatabaseIdentifier:12149328] PDB:1R5U [DatabaseIdentifier:12149304] PDB:3K1F [DatabaseIdentifier:12145606] PDB:7ML0 [DatabaseIdentifier:12149286] PDB:5OT2 [DatabaseIdentifier:12149279] PDB:4V1O [DatabaseIdentifier:12149268] PDB:2NVZ [DatabaseIdentifier:12163307] PDB:6RRD [DatabaseIdentifier:12149264] PDB:4BY7 [DatabaseIdentifier:12149276] PDB:1TWA [DatabaseIdentifier:12138683] PDB:7Z1L [DatabaseIdentifier:12149266] PDB:4Y52 [DatabaseIdentifier:12149290] PDB:3M4O [DatabaseIdentifier:12149269] PDB:1TWH [DatabaseIdentifier:12149287] PDB:7UIF [DatabaseIdentifier:12149297] PDB:1SFO [DatabaseIdentifier:12149294] PDB:3M3Y [DatabaseIdentifier:12149274] PDB:4V1N [DatabaseIdentifier:12149265] PDB:4BXX [DatabaseIdentifier:12149261] PDB:4BXZ [DatabaseIdentifier:12149277] PDB:4X6A [DatabaseIdentifier:12145617] PDB:7ZSA [DatabaseIdentifier:12149293] PDB:7UI9 [DatabaseIdentifier:12145613] PDB:7ZSB [DatabaseIdentifier:12145620] PDB:5OQM [DatabaseIdentifier:12138666] PDB:7Z0H [DatabaseIdentifier:12149272] PDB:1TWF [DatabaseIdentifier:12149263] PDB:2NVT [DatabaseIdentifier:12149258] PDB:7MEI [DatabaseIdentifier:11461272] ENSEMBL:YBR154C [DatabaseIdentifier:11554468] ENSEMBL:YBR154C [DatabaseIdentifier:11677167] ENSEMBL:YBR154C_mRNA [DatabaseIdentifier:12149262] PDB:2NVX [DatabaseIdentifier:12149289] PDB:7KED [DatabaseIdentifier:12149270] PDB:1TWG [DatabaseIdentifier:12222686] PDB:1DZF [DatabaseIdentifier:12149283] PDB:4X67 [DatabaseIdentifier:12149299] PDB:1K83 [DatabaseIdentifier:12149285] PDB:3CQZ [DatabaseIdentifier:12149296] PDB:1Y1V [DatabaseIdentifier:12149260] PDB:2NVY [DatabaseIdentifier:12138680] PDB:7Z1O [DatabaseIdentifier:12163308] PDB:5OA1 [DatabaseIdentifier:12149259] PDB:1NIK [DatabaseIdentifier:12138684] PDB:7Z1M [DatabaseIdentifier:12149298] PDB:1I3Q [DatabaseIdentifier:12149271] PDB:4Y7N [DatabaseIdentifier:12149257] PDB:2NVQ [DatabaseIdentifier:12163309] PDB:6RUI [DatabaseIdentifier:12149284] PDB:4A93 [DatabaseIdentifier:12149295] PDB:1Y1W [DatabaseIdentifier:12149273] PDB:4V1M [DatabaseIdentifier:12149275] PDB:1TWC [DatabaseIdentifier:12149282] PDB:2JA5 [DatabaseIdentifier:12149281] PDB:2JA6 [DatabaseIdentifier:12163310] PDB:6RUO [DatabaseIdentifier:12145615] PDB:5OQJ [DatabaseIdentifier:12149280] PDB:2JA7 [DatabaseIdentifier:12145622] PDB:7ZS9 [DatabaseIdentifier:12138678] PDB:7Z1N [DatabaseIdentifier:12149291] PDB:7KEE [DatabaseIdentifier:12149267] PDB:4BY1 [DatabaseIdentifier:12149278] PDB:2JA8 [DatabaseIdentifier:12145621] PDB:5FMF [DatabaseIdentifier:12149292] PDB:7KEF
databaseName	UniProt
dbId	100492
description	recommendedName: DNA-directed RNA polymerases I, II, and III subunit RPABC1 shortName: RNA polymerases I, II, and III subunit ABC1 alternativeName: ABC27 alternativeName: DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide
displayName	UniProt:P20434 RPB5
geneName	RPB5 RPA7 RPC9 YBR154C YBR1204
identifier	P20434
isSequenceChanged	false
keyword	3D-structure DNA-binding DNA-directed RNA polymerase Nucleus Reference proteome Ribosome biogenesis Transcription
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	RPB5
otherIdentifier	852451 GO:0000428 GO:0001054 GO:0001172 GO:0003677 GO:0003899 GO:0003968 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005665 GO:0005666 GO:0005736 GO:0006351 GO:0006352 GO:0006353 GO:0006354 GO:0006360 GO:0006361 GO:0006362 GO:0006363 GO:0006366 GO:0006367 GO:0006368 GO:0006383 GO:0006384 GO:0006386 GO:0016740 GO:0016779 GO:0042254 GO:0042790 GO:0042797
physicalEntity	[EntityWithAccessionedSequence:R-SCE-83713] RPB5 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-111833] RPB5_YEAST [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11325733] BioGPS Gene:852451 RPB5 [ReferenceDNASequence:12731581] UCSC:P20434 RPB5 [ReferenceDNASequence:11868096] KEGG:sce:YBR154C RPB5 [ReferenceDNASequence:11955522] Monarch:852451 RPB5 [ReferenceDNASequence:12039615] NCBI Gene:852451 RPB5
referenceTranscript	[ReferenceRNASequence:12524798] RefSeq:NM_001178502.1 RPB5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RPAB1_YEAST D6VQE9 Q02121
sequenceLength	215
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P20434
url	http://purl.uniprot.org/uniprot/P20434

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-83713] RPB5 [nucleoplasm] [EntityWithAccessionedSequence:R-SCE-111833] RPB5_YEAST [nucleoplasm]
(interactor)	[UndirectedInteraction:11136665] UniProt:P29055 <-> UniProt:P20434 (IntAct) [UndirectedInteraction:11187295] UniProt:P27692 <-> UniProt:P20434 (IntAct) [UndirectedInteraction:11193525] UniProt:P32558 <-> UniProt:P20434 (IntAct) [UndirectedInteraction:11237951] UniProt:P32914 <-> UniProt:P20434 (IntAct) [UndirectedInteraction:11277357] UniProt:P13393 <-> UniProt:P20434 (IntAct)

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