Reactome | UniProt:P19388 POLR2E

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UniProt:P19388 POLR2E Show undefined attributes

chain	chain:1-210
checksum	1E88AFDBCF9C8535
comment	FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template.SUBUNIT Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (PubMed:16809778, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218, PubMed:9852112). Pol I complex consists of a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk subunit POLR1F/RPA43 protruding from the core and additional subunits homologous to general transcription factors POLR1E/RPA49 and POLR1G/RPA34. Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex (PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol II complex contains a ten-subunit catalytic core composed of POLR2A/RPB1, POLR2B/RPB2, POLR2C/RPB3, POLR2I/RPB9, POLR2J/RPB11, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5 and a mobile stalk composed of two subunits POLR2D/RPB4 and POLR2G/RPB7. Part of Pol II(G) complex, in which Pol II core associates with an additional subunit POLR2M; unlike conventional Pol II, Pol II(G) functions as a transcriptional repressor. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms. In Pol II complex, this subunit is present in 2-fold molar excess over the other subunits (PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol III complex consists of a ten-subunit catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination (PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (PubMed:31738558). Interacts with URI1 (PubMed:9819440).SUBUNIT (Microbial infection) Interacts with HBV protein X.INTERACTION Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
crossReference	[DatabaseIdentifier:11460617] ENSEMBL:ENSG00000099817 [DatabaseIdentifier:12291891] Pharos - Targets:P19388 [DatabaseIdentifier:12254012] PRO:P19388 [DatabaseIdentifier:12142183] PDB:9LXN [DatabaseIdentifier:12142170] PDB:9FSS [DatabaseIdentifier:12142179] PDB:7AE1 [DatabaseIdentifier:12142187] PDB:8IUE [DatabaseIdentifier:12142188] PDB:8IUH [DatabaseIdentifier:12141429] PDB:7VBA [DatabaseIdentifier:12142185] PDB:7FJJ [DatabaseIdentifier:12138277] PDB:8XSO [DatabaseIdentifier:12142184] PDB:7FJI [DatabaseIdentifier:12141431] PDB:7VBB [DatabaseIdentifier:12142174] PDB:7AE3 [DatabaseIdentifier:12142182] PDB:9LXO [DatabaseIdentifier:12138286] PDB:9EI4 [DatabaseIdentifier:12142161] PDB:7D59 [DatabaseIdentifier:12138282] PDB:5IY7 [DatabaseIdentifier:12142162] PDB:8ITY [DatabaseIdentifier:12142166] PDB:9FSQ [DatabaseIdentifier:12142180] PDB:9K3U [DatabaseIdentifier:12138272] PDB:8XRJ [DatabaseIdentifier:12138289] PDB:6DRD [DatabaseIdentifier:12142168] PDB:9FSO [DatabaseIdentifier:12138288] PDB:6O9L [DatabaseIdentifier:12141428] PDB:7OBB [DatabaseIdentifier:12142173] PDB:7AEA [DatabaseIdentifier:12141433] PDB:7OBA [DatabaseIdentifier:12138284] PDB:9EI3 [DatabaseIdentifier:12162789] PDB:8A43 [DatabaseIdentifier:12138285] PDB:5IY9 [DatabaseIdentifier:12142169] PDB:9FSR [DatabaseIdentifier:12142186] PDB:9K3B [DatabaseIdentifier:12138287] PDB:9EI1 [DatabaseIdentifier:12142167] PDB:7AST [DatabaseIdentifier:12138273] PDB:5IYB [DatabaseIdentifier:12138274] PDB:9EHZ [DatabaseIdentifier:12142172] PDB:9K2G [DatabaseIdentifier:12138280] PDB:5IY6 [DatabaseIdentifier:12138290] PDB:7LBM [DatabaseIdentifier:12138279] PDB:8XVS [DatabaseIdentifier:12142178] PDB:9K3V [DatabaseIdentifier:12142164] PDB:9K36 [DatabaseIdentifier:12142175] PDB:7A6H [DatabaseIdentifier:12142157] PDB:9K39 [DatabaseIdentifier:12142160] PDB:7D58 [DatabaseIdentifier:12142163] PDB:9K38 [DatabaseIdentifier:12141430] PDB:7OB9 [DatabaseIdentifier:12138271] PDB:8XRM [DatabaseIdentifier:12138283] PDB:6XRE [DatabaseIdentifier:12138281] PDB:5IY8 [DatabaseIdentifier:12142165] PDB:9FSP [DatabaseIdentifier:12138275] PDB:5IYA [DatabaseIdentifier:12142158] PDB:9LKT [DatabaseIdentifier:12141432] PDB:7VBC [DatabaseIdentifier:12142181] PDB:7DU2 [DatabaseIdentifier:12138278] PDB:5IYC [DatabaseIdentifier:12142159] PDB:7DN3 [DatabaseIdentifier:12138276] PDB:5IYD [DatabaseIdentifier:12131705] OpenTargets:ENSG00000099817 [DatabaseIdentifier:11847039] HPA:ENSG00000099817-POLR2E [DatabaseIdentifier:11830940] HMDB Protein:HMDBP11911 [DatabaseIdentifier:11810001] GlyGen:P19388 [DatabaseIdentifier:11794054] GeneCards:POLR2E [DatabaseIdentifier:11676223] ENSEMBL:ENST00000612655 [DatabaseIdentifier:11676221] ENSEMBL:ENST00000615234 [DatabaseIdentifier:11676222] ENSEMBL:ENST00000586746 [DatabaseIdentifier:11553523] ENSEMBL:ENSP00000464739 [DatabaseIdentifier:11553524] ENSEMBL:ENSP00000478303 [DatabaseIdentifier:11553522] ENSEMBL:ENSP00000485021
databaseName	UniProt
dbId	63511
description	recommendedName: DNA-directed RNA polymerases I, II, and III subunit RPABC1 shortName: RNA polymerases I, II, and III subunit ABC1 alternativeName: DNA-directed RNA polymerase II 23 kDa polypeptide alternativeName: DNA-directed RNA polymerase II subunit E alternativeName: RPB5 homolog alternativeName: XAP4
displayName	UniProt:P19388 POLR2E
geneName	POLR2E
identifier	P19388
isSequenceChanged	false
keyword	3D-structure Acetylation Direct protein sequencing DNA-directed RNA polymerase Host-virus interaction Isopeptide bond Nucleus Proteomics identification Reference proteome Transcription Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	POLR2E
otherIdentifier	11716271_at 11716272_a_at 11716273_x_at 11750008_a_at 11750009_x_at 16866565 213887_PM_s_at 213887_s_at 217854_PM_s_at 217854_s_at 3348058 3348070 3844951 3844953 3844954 3844955 3844956 3844957 3844958 3844959 3844960 3844961 3844962 3844963 3844964 3844965 3844966 3844968 3844969 3844970 3844971 3844972 3844973 3844974 3844975 41332_at 5434 8032149 84752_r_at A_23_P165280 A_33_P3299829 A_33_P3299834 D38251_s_at GO:0000428 GO:0003677 GO:0003824 GO:0003899 GO:0005515 GO:0005634 GO:0005654 GO:0005665 GO:0005666 GO:0005730 GO:0005736 GO:0005829 GO:0006351 GO:0006362 GO:0006366 GO:0006399 GO:0016740 GO:0042797 GO:0050821 GO:0140098 GO:1990062 HMNXSV003026961 Hs.24301.1.S1_3p_a_at PH_hs_0031090 RNA95124\|RNS_206_189 TC19000996.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1964438] POLR2E [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-83713] POLR2E [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000099817] ENSEMBL:ENSG00000099817 POLR2E [ReferenceDNASequence:12678580] UCSC:P19388 POLR2E [ReferenceDNASequence:12116140] OMIM:180664 POLR2E [ReferenceDNASequence:12039054] NCBI Gene:5434 POLR2E [ReferenceDNASequence:11954961] Monarch:5434 POLR2E [ReferenceDNASequence:11867604] KEGG:hsa:5434 POLR2E [ReferenceDNASequence:11825749] HGNC:9192 POLR2E [ReferenceDNASequence:11427656] dbSNP Gene:5434 POLR2E [ReferenceDNASequence:11422715] CTD Gene:5434 POLR2E [ReferenceDNASequence:11391934] COSMIC - genes:POLR2E POLR2E [ReferenceDNASequence:11325172] BioGPS Gene:5434 POLR2E
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RPAB1_HUMAN B2R6L4 D6W5Y1 O43380 Q6PIH5 Q9BT06
sequenceLength	210
species	[Species:48887] Homo sapiens
stId	uniprot:P19388
url	http://purl.uniprot.org/uniprot/P19388

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