UniProt:P19320 VCAM1

chain
  • signal peptide:1-24
  • chain:25-739
  • chain:25-
checksum 050E2EBD39AC2FF4
comment
  • FUNCTION Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567).INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.INDUCTION By pro-inflammatory cytokines, including TNFalpha, and also by ROS, oxidized low density lipoprotein, high glucose concentration, toll-like receptor agonists, and shear stress.DOMAIN Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.PTM Cleaved by the metalloproteinase ADAM17 to generate the soluble form.PTM Sialoglycoprotein.PTM Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation.MISCELLANEOUS Major isoform.ONLINE INFORMATION VCAM1 entryONLINE INFORMATION VCAM-1
crossReference
databaseName UniProt
dbId 67138
description
  • recommendedName: Vascular cell adhesion protein 1 shortName: V-CAM 1 shortName: VCAM-1 alternativeName: INCAM-100 cdAntigenNameCD106/cdAntigenName component recommendedName: Soluble Vascular Cell Adhesion Molecule-1 /component
displayName UniProt:P19320 VCAM1
geneName
  • VCAM1
identifier P19320
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell adhesion
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin domain
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane
  • Transmembrane helix
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • VCAM1
otherIdentifier
  • 11719675_a_at
  • 11757425_s_at
  • 16667702
  • 203868_PM_s_at
  • 203868_s_at
  • 2349005
  • 2349006
  • 2349007
  • 2349008
  • 2349009
  • 2349011
  • 2349012
  • 2349017
  • 2349018
  • 2349019
  • 2349020
  • 2349021
  • 2349022
  • 2349023
  • 2349024
  • 2349025
  • 2349026
  • 2349027
  • 41433_at
  • 583_s_at
  • 7412
  • 7903358
  • 85611_r_at
  • A_14_P122495
  • A_14_P138814
  • GE58057
  • GO:0001666
  • GO:0002102
  • GO:0002376
  • GO:0002544
  • GO:0005178
  • GO:0005576
  • GO:0005615
  • GO:0005768
  • GO:0005769
  • GO:0005783
  • GO:0005794
  • GO:0005886
  • GO:0005902
  • GO:0006954
  • GO:0007155
  • GO:0007157
  • GO:0007159
  • GO:0007160
  • GO:0007584
  • GO:0008131
  • GO:0009308
  • GO:0009897
  • GO:0009986
  • GO:0010043
  • GO:0010212
  • GO:0016020
  • GO:0016491
  • GO:0022614
  • GO:0030154
  • GO:0030175
  • GO:0030183
  • GO:0032496
  • GO:0033631
  • GO:0034113
  • GO:0035094
  • GO:0035924
  • GO:0042102
  • GO:0042383
  • GO:0043226
  • GO:0045177
  • GO:0045471
  • GO:0048870
  • GO:0050839
  • GO:0050901
  • GO:0060326
  • GO:0060384
  • GO:0060945
  • GO:0070062
  • GO:0071065
  • GO:0071356
  • GO:0098609
  • GO:0098631
  • GO:1904646
  • HMNXSV003022758
  • ILMN_1766955
  • ILMN_2307903
  • ILMN_2325763
  • M30257_s_at
  • PH_hs_0006036
  • TC01000904.hg
  • g4507874_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • VCAM1_HUMAN
  • A8K6R7
  • B4DKS4
  • E9PDD1
  • Q6NUP8
sequenceLength 739
species [Species:48887] Homo sapiens
stId uniprot:P19320
url http://purl.uniprot.org/uniprot/P19320

Referrals

(referenceEntity)
(interactor)
Cite Us!