UniProt:P18887 XRCC1

chain
  • chain:1-633
checksum 76174967D034F89F
comment
  • FUNCTION Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483).SUBUNIT Homodimer (PubMed:16397295). Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3) (PubMed:19155274, PubMed:19336415). Interacts with APTX and APLF (PubMed:14755728, PubMed:15044383, PubMed:15380105, PubMed:17353262, PubMed:17507382). Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1 (PubMed:19934257). Interacts with (poly-ADP-ribosylated) PARP1 (PubMed:34811483).INTERACTION Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403). Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814).TISSUE SPECIFICITY Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).PTM Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.PTM Sumoylated.POLYMORPHISM Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference
databaseName UniProt
dbId 67456
description
  • recommendedName: fullName evidence="27"DNA repair protein XRCC1 alternativeName: X-ray repair cross-complementing protein 1
displayName UniProt:P18887 XRCC1
geneName
  • XRCC1
identifier P18887
isSequenceChanged false
keyword
  • 3D-structure
  • Chromosome
  • DNA damage
  • DNA repair
  • Isopeptide bond
  • Neurodegeneration
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • XRCC1
otherIdentifier
  • 11725480_s_at
  • 11745748_s_at
  • 160033_s_at
  • 16873015
  • 1829_at
  • 203655_PM_at
  • 203655_at
  • 3864448
  • 3864449
  • 3864450
  • 3864452
  • 3864454
  • 3864455
  • 3864456
  • 3864457
  • 3864458
  • 3864462
  • 3864463
  • 3864464
  • 3864465
  • 3864466
  • 3864467
  • 3864468
  • 3864469
  • 3864471
  • 3864472
  • 3864473
  • 3864474
  • 3864475
  • 3864478
  • 3864479
  • 3864480
  • 3864482
  • 7515
  • 8037331
  • A_23_P153692
  • GE57951
  • GO:0000012
  • GO:0000781
  • GO:0000785
  • GO:0003677
  • GO:0003684
  • GO:0003824
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0005730
  • GO:0006281
  • GO:0006284
  • GO:0006302
  • GO:0006303
  • GO:0006974
  • GO:0010836
  • GO:0016787
  • GO:0019899
  • GO:0021766
  • GO:0032356
  • GO:0033194
  • GO:0048856
  • GO:0061819
  • GO:0070522
  • GO:0072572
  • GO:0090734
  • GO:0140097
  • GO:0160002
  • GO:1905051
  • GO:1905765
  • GO:1990599
  • HMNXSV003052338
  • ILMN_1751743
  • M36089_at
  • PH_hs_0027195
  • TC19001589.hg
  • g5454171_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • XRCC1_HUMAN
  • Q6IBS4
  • Q9HCB1
sequenceLength 633
species [Species:48887] Homo sapiens
stId uniprot:P18887
url http://purl.uniprot.org/uniprot/P18887
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