Reactome | UniProt:P18827 SDC1

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UniProt:P18827 SDC1 Show undefined attributes

chain	signal peptide:1-22 chain:23-310
checksum	8E9EF4A57F5FDBD0
comment	FUNCTION Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity).SUBUNIT Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Interacts with MDK (By similarity).INTERACTION Shedding of the ectodomain produces a soluble form.TISSUE SPECIFICITY Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313).PTM Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.SIMILARITY Belongs to the syndecan proteoglycan family.
crossReference	[DatabaseIdentifier:11483341] ENSEMBL:ENSG00000115884 [DatabaseIdentifier:12392047] RefSeq:NP_001006947.2 [DatabaseIdentifier:12293531] Pharos - Targets:P18827 [DatabaseIdentifier:12276736] PRO:P18827 [DatabaseIdentifier:12140990] PDB:6EJE [DatabaseIdentifier:12229773] PDB:4GVD [DatabaseIdentifier:12229772] PDB:4GVC [DatabaseIdentifier:12133363] OpenTargets:ENSG00000115884 [DatabaseIdentifier:11848672] HPA:ENSG00000115884-SDC1 [DatabaseIdentifier:11832791] HMDB Protein:HMDBP02143 [DatabaseIdentifier:11811512] GlyGen:P18827 [DatabaseIdentifier:11795705] GeneCards:SDC1 [DatabaseIdentifier:11708063] ENSEMBL:ENST00000381150 [DatabaseIdentifier:11708062] ENSEMBL:ENST00000254351 [DatabaseIdentifier:11585364] ENSEMBL:ENSP00000370542 [DatabaseIdentifier:11585363] ENSEMBL:ENSP00000254351
databaseName	UniProt
dbId	64228
description	recommendedName: fullName evidence="19"Syndecan-1 shortName evidence="19"SYND1 cdAntigenNameCD138/cdAntigenName
displayName	UniProt:P18827 SDC1
geneName	SDC1 SDC
identifier	P18827
isSequenceChanged	false
keyword	3D-structure Glycoprotein Heparan sulfate Membrane Phosphoprotein Proteoglycan Proteomics identification Reference proteome Secreted Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SDC1
otherIdentifier	11716577_s_at 11752754_s_at 11758139_s_at 16894911 201286_PM_at 201286_at 201287_PM_s_at 201287_s_at 2542796 2542797 2542798 2542799 2542800 2542801 2542802 2542810 2542811 2542812 2542813 2542814 2542815 38127_at 6382 8050557 A_23_P16944 A_24_P97129 GE60412 GO:0005515 GO:0005576 GO:0005796 GO:0005886 GO:0006898 GO:0009897 GO:0009986 GO:0016020 GO:0016192 GO:0016477 GO:0038024 GO:0042802 GO:0043202 GO:0048627 GO:0048856 GO:0048870 GO:0055002 GO:0060070 GO:0070062 GO:1903543 GO:1903553 HMNXSV003006280 Hs.82109.0.S2_3p_at ILMN_1768953 ILMN_1800038 ILMN_1815308 PH_hs_0004693 TC02001619.hg Z48199_at g4506858_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2076693] HS(4)-SDC1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076652] HS(6)-SDC1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076666] HS(2)-SDC1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076672] HS(1)-SDC1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076691] HS(3)-SDC1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076626] HS(5)-SDC1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-174758] SDC1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2054105] SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064146] XylS-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064148] Gal-Xyl-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064247] Gal-Gal-Xyl-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064082] GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076561] Heparan-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076349] Heparan(1)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076558] Heparan(2)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076314] Heparan(3)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076339] Heparan(4)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076321] HS(1)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076309] HS(2)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076444] HS(3)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076593] HS(4)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076290] HS(5)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2076520] HS(6)-SDC1 [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2090082] HS(6)-SDC1 [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9941005] GlcA-Gal-Gal-XylP-SDC1 [Golgi lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000115884] ENSEMBL:ENSG00000115884 SDC1 [ReferenceDNASequence:12694729] UCSC:P18827 SDC1 [ReferenceDNASequence:12117637] OMIM:186355 SDC1 [ReferenceDNASequence:12062618] NCBI Gene:6382 SDC1 [ReferenceDNASequence:11978525] Monarch:6382 SDC1 [ReferenceDNASequence:11888686] KEGG:hsa:6382 SDC1 [ReferenceDNASequence:11827409] HGNC:10658 SDC1 [ReferenceDNASequence:11429357] dbSNP Gene:6382 SDC1 [ReferenceDNASequence:11424726] CTD Gene:6382 SDC1 [ReferenceDNASequence:11393402] COSMIC - genes:SDC1 SDC1 [ReferenceDNASequence:11348736] BioGPS Gene:6382 SDC1
referenceTranscript	[ReferenceRNASequence:12573795] RefSeq:NM_001006946.2 SDC1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SDC1_HUMAN D6W523 Q53QV0 Q546D3 Q96HB7
sequenceLength	310
species	[Species:48887] Homo sapiens
stId	uniprot:P18827
url	http://purl.uniprot.org/uniprot/P18827

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2076693] HS(4)-SDC1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2076652] HS(6)-SDC1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2076666] HS(2)-SDC1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2076672] HS(1)-SDC1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2076691] HS(3)-SDC1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2076626] HS(5)-SDC1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-174758] SDC1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2054105] SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2064146] XylS-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2064148] Gal-Xyl-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2064247] Gal-Gal-Xyl-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2064082] GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076561] Heparan-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076349] Heparan(1)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076558] Heparan(2)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076314] Heparan(3)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076339] Heparan(4)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076321] HS(1)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076309] HS(2)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076444] HS(3)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076593] HS(4)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076290] HS(5)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2076520] HS(6)-SDC1 [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-2090082] HS(6)-SDC1 [lysosomal lumen] [EntityWithAccessionedSequence:R-HSA-9941005] GlcA-Gal-Gal-XylP-SDC1 [Golgi lumen]
(referenceSequence)	[GroupModifiedResidue:2076537] O-xylosyl-L-serine (ChEBI:63657) at unknown position [GroupModifiedResidue:2076322] O-xylosyl-L-serine (ChEBI:63666) at unknown position [GroupModifiedResidue:2076523] O-xylosyl-L-serine (ChEBI:63653) at unknown position [GroupModifiedResidue:2076284] O-xylosyl-L-serine (ChEBI:63652) at unknown position [GroupModifiedResidue:2076559] O-xylosyl-L-serine (ChEBI:63654) at unknown position [GroupModifiedResidue:2076450] O-xylosyl-L-serine (ChEBI:63661) at unknown position [ModifiedResidue:2064198] O-xylosyl-L-serine at unknown position [GroupModifiedResidue:2063991] O-xylosyl-L-serine (O3-(4-?-D-galactosyl-?-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2064051] O-xylosyl-L-serine (O3-(?-D-galactosyl-(1?3)-?-D-galactosyl-(1?4)-?-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2064105] O-xylosyl-L-serine (3-O-(?-D-glucuronosyl-(1?3)-?-D-galactosyl-(1?3)-?-D-galactosyl-(1?4)-?-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2076540] O-xylosyl-L-serine (ChEBI:63645) at unknown position [GroupModifiedResidue:2076345] O-xylosyl-L-serine (ChEBI:63646) at unknown position [GroupModifiedResidue:2076375] O-xylosyl-L-serine (ChEBI:63648) at unknown position [GroupModifiedResidue:2076348] O-xylosyl-L-serine (ChEBI:63649) at unknown position [GroupModifiedResidue:2076614] O-xylosyl-L-serine (ChEBI:63651) at unknown position [GroupModifiedResidue:9941208] O-xylosyl-L-serine (O3-(?-D-glucuronosyl-(1?3)-?-D-galactosyl-(1?3)-?-D-galactosyl-(1?4)-?-D-2-O-phospho-xylosyl)-L-serine residue) at unknown position
(interactor)	[UndirectedInteraction:11138815] UniProt:P18827 <-> UniProt:P0DTL6 (IntAct) [UndirectedInteraction:11138811] UniProt:P18827 <-> UniProt:Q8TAA9 (IntAct) [UndirectedInteraction:11138809] UniProt:P18827 <-> UniProt:P05230 (IntAct) [UndirectedInteraction:11138807] UniProt:P18827 <-> UniProt:Q9HAV0 (IntAct) [UndirectedInteraction:11138805] UniProt:P18827 <-> UniProt:P29317 (IntAct) [UndirectedInteraction:11138803] UniProt:P18827 <-> UniProt:Q01581 (IntAct) [UndirectedInteraction:11138801] UniProt:P18827 <-> UniProt:Q9C0B1 (IntAct) [UndirectedInteraction:11138799] UniProt:P18827 <-> UniProt:Q7L9B9 (IntAct) [UndirectedInteraction:11138797] UniProt:P18827 <-> UniProt:P78368 (IntAct) [UndirectedInteraction:11138795] UniProt:P18827 <-> UniProt:Q9UER7 (IntAct) [UndirectedInteraction:11138793] UniProt:P18827 <-> UniProt:Q9Y692 (IntAct) [UndirectedInteraction:11138791] UniProt:P18827 <-> UniProt:Q8WUM4 (IntAct) [UndirectedInteraction:11138789] UniProt:P18827 <-> UniProt:P05067 (IntAct) [UndirectedInteraction:11138787] UniProt:P18827 <-> UniProt:Q09666 (IntAct) [UndirectedInteraction:11138783] UniProt:P18827 <-> UniProt:Q99985 (IntAct) [UndirectedInteraction:11138779] UniProt:P18827 <-> UniProt:O95470 (IntAct) [UndirectedInteraction:11138777] UniProt:P18827 <-> UniProt:Q03468 (IntAct) [UndirectedInteraction:11138775] UniProt:P18827 <-> UniProt:Q6NZI2 (IntAct) [UndirectedInteraction:11138773] UniProt:P18827 <-> UniProt:Q14699 (IntAct) [UndirectedInteraction:11138769] UniProt:P18827 <-> UniProt:P34741 (IntAct) [UndirectedInteraction:11138767] UniProt:P18827 <-> UniProt:Q9UKD1 (IntAct) [UndirectedInteraction:11138765] UniProt:P18827 <-> UniProt:Q16625 (IntAct) [UndirectedInteraction:11138763] UniProt:P18827 <-> UniProt:Q8NCB2 (IntAct) [UndirectedInteraction:11138761] UniProt:P18827 <-> UniProt:Q9Y4F1 (IntAct) [UndirectedInteraction:11138759] UniProt:P18827 <-> UniProt:O15530 (IntAct) [UndirectedInteraction:11138757] UniProt:P18827 <-> UniProt:Q13268 (IntAct) [UndirectedInteraction:11138753] UniProt:P18827 <-> UniProt:Q13009 (IntAct) [UndirectedInteraction:11137631] UniProt:P09038 <-> UniProt:P18827 (IntAct) [UndirectedInteraction:11138747] UniProt:P18827 <-> UniProt:P40939 (IntAct) [UndirectedInteraction:11138749] UniProt:P18827 <-> UniProt:Q01433 (IntAct) [UndirectedInteraction:11138751] UniProt:P18827 <-> UniProt:P18827 (IntAct) [UndirectedInteraction:11138751] UniProt:P18827 <-> UniProt:P18827 (IntAct)

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