Reactome | UniProt:P18754 RCC1

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UniProt:P18754 RCC1 Show undefined attributes

chain	initiator methionine:1 chain:2-421
checksum	F6D225AF81928305
comment	FUNCTION Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580).SUBUNIT Interacts with RAN (PubMed:11336674, PubMed:17435751, PubMed:18762580, PubMed:29040603). Interacts with KPNA3 (PubMed:34564892). Interacts (via N-terminus and RCC1 repeats) with KPNA4 (PubMed:29042532). Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation (PubMed:16820410).INTERACTION Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449).ALTERNATIVE PRODUCTS N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Patients with Raynaud disease produce antibodies that bind to RCC1.
crossReference	[DatabaseIdentifier:12166678] PDB:5E1D [DatabaseIdentifier:12389904] RefSeq:NP_001041664.1 [DatabaseIdentifier:12389906] RefSeq:NP_001041659.1 [DatabaseIdentifier:12389905] RefSeq:NP_001041660.1 [DatabaseIdentifier:12389908] RefSeq:NP_001368795.1 [DatabaseIdentifier:12389907] RefSeq:NP_001260.1 [DatabaseIdentifier:12389909] RefSeq:NP_001368794.1 [DatabaseIdentifier:12292560] Pharos - Targets:P18754 [DatabaseIdentifier:12275628] PRO:P18754 [DatabaseIdentifier:12166676] PDB:5E1B [DatabaseIdentifier:12165921] PDB:8UX1 [DatabaseIdentifier:12224024] PDB:1A12 [DatabaseIdentifier:12224023] PDB:6DUB [DatabaseIdentifier:12166673] PDB:5E1O [DatabaseIdentifier:12166669] PDB:5E2A [DatabaseIdentifier:12166672] PDB:5E1M [DatabaseIdentifier:11482363] ENSEMBL:ENSG00000180198 [DatabaseIdentifier:11583885] ENSEMBL:ENSP00000362937 [DatabaseIdentifier:11583888] ENSEMBL:ENSP00000381931 [DatabaseIdentifier:11583889] ENSEMBL:ENSP00000508074 [DatabaseIdentifier:11583884] ENSEMBL:ENSP00000497402 [DatabaseIdentifier:11583887] ENSEMBL:ENSP00000362939 [DatabaseIdentifier:11583886] ENSEMBL:ENSP00000362938 [DatabaseIdentifier:11706584] ENSEMBL:ENST00000649185 [DatabaseIdentifier:11706583] ENSEMBL:ENST00000398958 [DatabaseIdentifier:11706587] ENSEMBL:ENST00000373833 [DatabaseIdentifier:11706586] ENSEMBL:ENST00000373831 [DatabaseIdentifier:11706585] ENSEMBL:ENST00000683442 [DatabaseIdentifier:11706588] ENSEMBL:ENST00000373832 [DatabaseIdentifier:11794737] GeneCards:RCC1 [DatabaseIdentifier:11810682] GlyGen:P18754 [DatabaseIdentifier:11831838] HMDB Protein:HMDBP08535 [DatabaseIdentifier:11847706] HPA:ENSG00000180198-RCC1 [DatabaseIdentifier:12132389] OpenTargets:ENSG00000180198 [DatabaseIdentifier:12179673] PDB:1I2M [DatabaseIdentifier:12166677] PDB:5E2B [DatabaseIdentifier:12221869] PDB:5TBK
databaseName	UniProt
dbId	69901
description	recommendedName: Regulator of chromosome condensation alternativeName: Cell cycle regulatory protein alternativeName: Chromosome condensation protein 1
displayName	UniProt:P18754 RCC1
geneName	RCC1 CHC1
identifier	P18754
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell cycle Cell division Chromosome Cytoplasm Direct protein sequencing Disease variant DNA-binding Guanine-nucleotide releasing factor Methylation Mitosis Neuropathy Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	RCC1
otherIdentifier	1104 11739421_a_at 11741252_a_at 1196_at 16661589 206499_PM_s_at 206499_s_at 215747_PM_s_at 215747_s_at 2327483 2327487 2327491 2327498 2327500 2327501 2327503 2327504 2327505 2327506 2327507 2327508 2327509 2327510 2327511 2327512 2327513 2327514 2327515 2327516 2327517 2327518 2327519 2327520 2327521 2327522 2327533 2327539 2327540 2327541 3267024 37927_at 7899462 A_14_P120765 A_23_P46309 A_24_P930442 D00591_at GE59704 GO:0000082 GO:0000228 GO:0000785 GO:0000794 GO:0003677 GO:0003682 GO:0005085 GO:0005515 GO:0005634 GO:0005654 GO:0005694 GO:0005737 GO:0007010 GO:0007052 GO:0007059 GO:0007084 GO:0007088 GO:0007346 GO:0016032 GO:0031267 GO:0031491 GO:0031492 GO:0032991 GO:0042393 GO:0043199 GO:0046982 GO:0051225 GO:0051301 GO:0061024 GO:1901673 HMNXSV003030318 Hs.84746.2.S1_3p_a_at ILMN_1707493 ILMN_2311497 ILMN_2354211 PH_hs_0030839 PH_hs_0032120 TC01000381.hg TC01004267.hg g4502800_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9668547] RCC1 [chromosome] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-180690] RCC1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000180198] ENSEMBL:ENSG00000180198 RCC1 [ReferenceDNASequence:12694168] UCSC:P18754 RCC1 [ReferenceDNASequence:11347818] BioGPS Gene:1104 RCC1 [ReferenceDNASequence:11393281] COSMIC - genes:RCC1 RCC1 [ReferenceDNASequence:11423559] CTD Gene:1104 RCC1 [ReferenceDNASequence:11429218] dbSNP Gene:1104 RCC1 [ReferenceDNASequence:11826433] HGNC:1913 RCC1 [ReferenceDNASequence:11887821] KEGG:hsa:1104 RCC1 [ReferenceDNASequence:11977607] Monarch:1104 RCC1 [ReferenceDNASequence:12061700] NCBI Gene:1104 RCC1 [ReferenceDNASequence:12116750] OMIM:179710 RCC1
referenceTranscript	[ReferenceRNASequence:12571674] RefSeq:NM_001048194.4 RCC1 [ReferenceRNASequence:12571675] RefSeq:NM_001048195.2 RCC1 [ReferenceRNASequence:12571673] RefSeq:NM_001381865.2 RCC1 [ReferenceRNASequence:12571670] RefSeq:NM_001048199.3 RCC1 [ReferenceRNASequence:12571671] RefSeq:NM_001269.6 RCC1 [ReferenceRNASequence:12571672] RefSeq:NM_001381866.2 RCC1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RCC1_HUMAN Q16269 Q6NT97
sequenceLength	421
species	[Species:48887] Homo sapiens
stId	uniprot:P18754
url	http://purl.uniprot.org/uniprot/P18754

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