Reactome | UniProt:P18669 PGAM1

chain	initiator methionine:1 chain:2-254
checksum	6DC0852BEBB22409
comment	FUNCTION Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate, a crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).CATALYTIC ACTIVITY (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerateCATALYTIC ACTIVITY (2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)SUBUNIT Homodimer.INTERACTION Expressed in the liver and brain. Not found in the muscle.PTM Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.SIMILARITY Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
crossReference	[DatabaseIdentifier:12234156] PDB:5Y35 [DatabaseIdentifier:12817304] ZINC target:P18669 [DatabaseIdentifier:12813876] ZINC - Substances:PGAM1_HUMAN [DatabaseIdentifier:12394236] RefSeq:NP_002620.1 [DatabaseIdentifier:12294541] Pharos - Targets:P18669 [DatabaseIdentifier:12278068] PRO:P18669 [DatabaseIdentifier:12234141] PDB:8IT4 [DatabaseIdentifier:12234154] PDB:8ITD [DatabaseIdentifier:11484361] ENSEMBL:ENSG00000171314 [DatabaseIdentifier:11586870] ENSEMBL:ENSP00000359991 [DatabaseIdentifier:11709569] ENSEMBL:ENST00000334828 [DatabaseIdentifier:11796717] GeneCards:PGAM1 [DatabaseIdentifier:11812513] GlyGen:P18669 [DatabaseIdentifier:11833918] HMDB Protein:HMDBP00269 [DatabaseIdentifier:11849679] HPA:ENSG00000171314-PGAM1 [DatabaseIdentifier:12134378] OpenTargets:ENSG00000171314 [DatabaseIdentifier:12234147] PDB:4GPI [DatabaseIdentifier:12234149] PDB:5ZRM [DatabaseIdentifier:12234138] PDB:9LG2 [DatabaseIdentifier:12234146] PDB:5ZS8 [DatabaseIdentifier:12234153] PDB:5Y64 [DatabaseIdentifier:12234144] PDB:8IT7 [DatabaseIdentifier:12234150] PDB:1YFK [DatabaseIdentifier:12234137] PDB:8ITB [DatabaseIdentifier:12234139] PDB:8IT5 [DatabaseIdentifier:12234142] PDB:7XB7 [DatabaseIdentifier:12234140] PDB:8IT6 [DatabaseIdentifier:12234148] PDB:6ISN [DatabaseIdentifier:12234152] PDB:8ITC [DatabaseIdentifier:12234136] PDB:4GPZ [DatabaseIdentifier:12234151] PDB:5Y65 [DatabaseIdentifier:12234155] PDB:5Y2U [DatabaseIdentifier:12234145] PDB:8IT8 [DatabaseIdentifier:12234134] PDB:5Y2I [DatabaseIdentifier:12234133] PDB:1YJX [DatabaseIdentifier:12234143] PDB:7XB8 [DatabaseIdentifier:12234135] PDB:7XB9
databaseName	UniProt
dbId	61882
description	recommendedName: fullName evidence="9"Phosphoglycerate mutase 1 ecNumber evidence="6"5.4.2.11 ecNumber evidence="6"5.4.2.4 alternativeName: BPG-dependent PGAM 1 alternativeName: Phosphoglycerate mutase isozyme B shortName: PGAM-B
displayName	UniProt:P18669 PGAM1
geneName	PGAM1 PGAMA CDABP0006
identifier	P18669
isSequenceChanged	false
keyword	3D-structure Acetylation Direct protein sequencing Glycolysis Hydrolase Isomerase Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	PGAM1
otherIdentifier	11720915_x_at 11750286_x_at 11750438_x_at 11758691_x_at 16707970 200886_PM_s_at 200886_s_at 3259818 3259819 3259820 3259822 3259823 3259825 3259826 3259828 3259829 3259831 3259832 3259833 3377513 3377514 3429393 3429394 3429395 3429396 3429397 3429398 3429399 3465907 3465908 3465909 3465910 3465911 3465912 3465913 3465914 4013423 4013425 4013426 4013427 4056164 4056166 4056168 4056169 41221_at 5223 68315_at 7929624 7958152 7965480 8173729 8176282 A_32_P45738 A_33_P3268334 GE57505 GO:0003824 GO:0004082 GO:0004619 GO:0005515 GO:0005576 GO:0005737 GO:0005829 GO:0005975 GO:0006091 GO:0006094 GO:0006096 GO:0016020 GO:0016787 GO:0016853 GO:0016868 GO:0019901 GO:0034774 GO:0055086 GO:0061621 GO:0070062 GO:1901135 GO:1904813 HMNXSV003020829 ILMN_1661366 ILMN_2112417 J04173_at PH_hs_0030347 TC10000695.hg TC12000806.hg g4505752_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-71442] PGAM1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6803309] PGAM1 [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6806482] PGAM1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6803293] PGAM1 [secretory granule lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000171314] ENSEMBL:ENSG00000171314 PGAM1 [ReferenceDNASequence:12695309] UCSC:P18669 PGAM1 [ReferenceDNASequence:11349649] BioGPS Gene:5223 PGAM1 [ReferenceDNASequence:11393576] COSMIC - genes:PGAM1 PGAM1 [ReferenceDNASequence:11426003] CTD Gene:5223 PGAM1 [ReferenceDNASequence:11429549] dbSNP Gene:5223 PGAM1 [ReferenceDNASequence:11828425] HGNC:8888 PGAM1 [ReferenceDNASequence:11889518] KEGG:hsa:5223 PGAM1 [ReferenceDNASequence:11979438] Monarch:5223 PGAM1 [ReferenceDNASequence:12063531] NCBI Gene:5223 PGAM1 [ReferenceDNASequence:12118563] OMIM:172250 PGAM1
referenceTranscript	[ReferenceRNASequence:12576003] RefSeq:NM_002629.4 PGAM1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PGAM1_HUMAN Q9BWC0
sequenceLength	254
species	[Species:48887] Homo sapiens
stId	uniprot:P18669
url	http://purl.uniprot.org/uniprot/P18669

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-71442] PGAM1 [cytosol] [EntityWithAccessionedSequence:R-HSA-6803309] PGAM1 [ficolin-1-rich granule lumen] [EntityWithAccessionedSequence:R-HSA-6806482] PGAM1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-6803293] PGAM1 [secretory granule lumen]
(interactor)	[UndirectedInteraction:11148017] UniProt:P13569 <-> UniProt:P18669 (IntAct) [UndirectedInteraction:11218567] UniProt:P10636-8 <-> UniProt:P18669 (IntAct) [UndirectedInteraction:11273483] UniProt:P05067 <-> UniProt:P18669 (IntAct) [UndirectedInteraction:11287315] UniProt:P12004 <-> UniProt:P18669 (IntAct)

UniProt:P18669 PGAM1 Show undefined attributes

Referrals