UniProt:P18440 NAT1

chain
  • chain:1-290
checksum C015F7F3D4830107
comment
  • FUNCTION Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.CATALYTIC ACTIVITY an arylamine + acetyl-CoA = an N-acetylarylamine + CoAINTERACTION N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder (PubMed:7585580).MISCELLANEOUS NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.SIMILARITY Belongs to the arylamine N-acetyltransferase family.CAUTION The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee.ONLINE INFORMATION NAT alleles
crossReference
databaseName UniProt
dbId 50343
description
  • recommendedName: Arylamine N-acetyltransferase 1 ecNumber: 2.3.1.5 alternativeName: Arylamide acetylase 1 alternativeName: Monomorphic arylamine N-acetyltransferase shortName: MNAT alternativeName: N-acetyltransferase type 1 shortName: NAT-1
displayName UniProt:P18440 NAT1
geneName
  • NAT1
  • AAC1
identifier P18440
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Acyltransferase
  • Cytoplasm
  • Proteomics identification
  • Reference proteome
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • NAT1
otherIdentifier
  • 11748981_a_at
  • 17066183
  • 214440_PM_at
  • 214440_at
  • 3087948
  • 3087952
  • 3087953
  • 3087956
  • 3087957
  • 3087958
  • 3087959
  • 3087960
  • 3087961
  • 3087962
  • 3087963
  • 3087964
  • 3087965
  • 3087967
  • 38187_at
  • 66045_at
  • 8144857
  • 9
  • A_14_P129288
  • A_23_P95594
  • GE79506
  • GO:0004060
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0006805
  • GO:0016407
  • GO:0016740
  • GO:0016746
  • HMNXSV003024754
  • Hs.155956.0.S1_3p_at
  • ILMN_1688071
  • ILMN_1708402
  • ILMN_1743055
  • PH_hs_0030469
  • TC08001820.hg
  • TC08001821.hg
  • X17059_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ARY1_HUMAN
  • A8K4E7
  • O15159
  • O15300
  • Q546N1
  • Q96TE9
sequenceLength 290
species [Species:48887] Homo sapiens
stId uniprot:P18440
url http://purl.uniprot.org/uniprot/P18440
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