UniProt:P18146 EGR1

chain
  • chain:1-543
checksum 768CE670D9743E4E
comment
  • FUNCTION Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).SUBUNIT Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.INTERACTION Detected in neutrophils (at protein level).INDUCTION By growth factors.DOMAIN Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).SIMILARITY Belongs to the EGR C2H2-type zinc-finger protein family.
crossReference
databaseName UniProt
dbId 54214
description
  • recommendedName: fullName evidence="9"Early growth response protein 1 shortName evidence="9"EGR-1 alternativeName: AT225 alternativeName: Nerve growth factor-induced protein A shortName: NGFI-A alternativeName: Transcription factor ETR103 alternativeName: Transcription factor Zif268 alternativeName: fullName evidence="8"Zinc finger protein 225 alternativeName: Zinc finger protein Krox-24
displayName UniProt:P18146 EGR1
geneName
  • EGR1
  • KROX24
  • ZNF225
identifier P18146
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • Biological rhythms
  • Cytoplasm
  • DNA-binding
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • EGR1
otherIdentifier
  • 11717860_a_at
  • 11717861_a_at
  • 11717862_x_at
  • 11751643_x_at
  • 11752940_a_at
  • 11754334_s_at
  • 16989736
  • 1958
  • 201693_PM_s_at
  • 201693_s_at
  • 201694_PM_s_at
  • 201694_s_at
  • 2830871
  • 2830872
  • 2830873
  • 2830874
  • 2830875
  • 2830878
  • 2830879
  • 2830880
  • 2830881
  • 2830882
  • 2830883
  • 2830884
  • 2830885
  • 2830886
  • 2830887
  • 2830888
  • 2830889
  • 2830890
  • 2830891
  • 789_at
  • 8108370
  • A_23_P214080
  • GE81094
  • GO:0000122
  • GO:0000785
  • GO:0000976
  • GO:0000977
  • GO:0000978
  • GO:0000981
  • GO:0001228
  • GO:0001666
  • GO:0002376
  • GO:0002931
  • GO:0003677
  • GO:0003700
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0006325
  • GO:0006355
  • GO:0006357
  • GO:0008270
  • GO:0009749
  • GO:0010385
  • GO:0010628
  • GO:0019899
  • GO:0022414
  • GO:0030154
  • GO:0030217
  • GO:0030509
  • GO:0032722
  • GO:0032731
  • GO:0032868
  • GO:0032922
  • GO:0033233
  • GO:0035035
  • GO:0035914
  • GO:0042981
  • GO:0043523
  • GO:0043565
  • GO:0044029
  • GO:0044729
  • GO:0044849
  • GO:0045475
  • GO:0045893
  • GO:0045944
  • GO:0046872
  • GO:0046886
  • GO:0048511
  • GO:0060086
  • GO:0070498
  • GO:0071456
  • GO:0071480
  • GO:0071504
  • GO:0071506
  • GO:0072110
  • GO:0072303
  • GO:0090090
  • GO:0098759
  • GO:1901875
  • GO:1902895
  • GO:1990837
  • GO:1990841
  • GO:2000182
  • HMNXSV003040192
  • Hs.326035.0.A1_3p_a_at
  • ILMN_1762899
  • PH_hs_0016176
  • TC05000701.hg
  • X52541_at
  • g4503492_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • EGR1_HUMAN
sequenceLength 543
species [Species:48887] Homo sapiens
stId uniprot:P18146
url http://purl.uniprot.org/uniprot/P18146
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