Reactome | UniProt:P18031 PTPN1

chain	chain:1-435
checksum	802377DCD33F41FD
comment	FUNCTION Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateSUBUNIT Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function (PubMed:21135139). Interacts with MET (PubMed:18819921). Interacts with NCK1 (PubMed:21707536).INTERACTION Interacts with EPHA3 at the cell membrane.TISSUE SPECIFICITY Expressed in keratinocytes (at protein level).PTM Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.PTM Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.PTM S-nitrosylation of Cys-215 inactivates the enzyme activity.PTM Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
crossReference	[DatabaseIdentifier:11481562] ENSEMBL:ENSG00000196396 [DatabaseIdentifier:12818188] ZINC - World Drugs:PTN1_HUMAN [DatabaseIdentifier:12815402] ZINC target:P18031 [DatabaseIdentifier:12812053] ZINC - Substances:PTN1_HUMAN [DatabaseIdentifier:12810108] ZINC - Predictions - Purchasable:PTN1_HUMAN [DatabaseIdentifier:12807963] ZINC - Metabolites:PTN1_HUMAN [DatabaseIdentifier:12806683] ZINC - Investigational:PTN1_HUMAN [DatabaseIdentifier:12805614] ZINC - FDA approved:PTN1_HUMAN [DatabaseIdentifier:12804463] ZINC - Biogenic:PTN1_HUMAN [DatabaseIdentifier:12388094] RefSeq:NP_002818.1 [DatabaseIdentifier:12388095] RefSeq:NP_001265547.1 [DatabaseIdentifier:12291943] Pharos - Targets:P18031 [DatabaseIdentifier:12274757] PRO:P18031 [DatabaseIdentifier:12221097] PDB:9CYO [DatabaseIdentifier:12221083] PDB:4QAP [DatabaseIdentifier:12221104] PDB:3I7Z [DatabaseIdentifier:12221107] PDB:3I80 [DatabaseIdentifier:12221079] PDB:2CM2 [DatabaseIdentifier:12221075] PDB:3ZV2 [DatabaseIdentifier:12221095] PDB:9CYQ [DatabaseIdentifier:12221081] PDB:2CM7 [DatabaseIdentifier:12221089] PDB:2CMB [DatabaseIdentifier:12221108] PDB:1KAV [DatabaseIdentifier:12221086] PDB:4QBW [DatabaseIdentifier:12221077] PDB:1OEO [DatabaseIdentifier:12221084] PDB:7KLX [DatabaseIdentifier:12221071] PDB:1OEU [DatabaseIdentifier:12221082] PDB:4Y14 [DatabaseIdentifier:12221105] PDB:6BAI [DatabaseIdentifier:12221072] PDB:1OET [DatabaseIdentifier:12221096] PDB:9CYR [DatabaseIdentifier:12221103] PDB:2CNE [DatabaseIdentifier:12221102] PDB:2CNF [DatabaseIdentifier:12221100] PDB:2CNH [DatabaseIdentifier:12221091] PDB:2CMA [DatabaseIdentifier:12221099] PDB:9CYP [DatabaseIdentifier:12221093] PDB:7L0C [DatabaseIdentifier:12221087] PDB:2CMC [DatabaseIdentifier:12221092] PDB:4QBE [DatabaseIdentifier:12221094] PDB:7L0H [DatabaseIdentifier:12221076] PDB:2H4G [DatabaseIdentifier:12221074] PDB:1OES [DatabaseIdentifier:12221098] PDB:2CNI [DatabaseIdentifier:12221085] PDB:4QAH [DatabaseIdentifier:12221088] PDB:1G7G [DatabaseIdentifier:12221106] PDB:1KAK [DatabaseIdentifier:12221080] PDB:2CM8 [DatabaseIdentifier:12221101] PDB:2CNG [DatabaseIdentifier:12221073] PDB:2H4K [DatabaseIdentifier:12221078] PDB:2CM3 [DatabaseIdentifier:12221070] PDB:1OEV [DatabaseIdentifier:12221090] PDB:1G7F [DatabaseIdentifier:12221009] PDB:3EB1 [DatabaseIdentifier:12221040] PDB:6B8Z [DatabaseIdentifier:12221066] PDB:6NTP [DatabaseIdentifier:12221047] PDB:1G1F [DatabaseIdentifier:12221001] PDB:1NZ7 [DatabaseIdentifier:12221000] PDB:2VEU [DatabaseIdentifier:12220983] PDB:3A5J [DatabaseIdentifier:12221007] PDB:6OL4 [DatabaseIdentifier:12220999] PDB:8U1E [DatabaseIdentifier:12221059] PDB:7MNE [DatabaseIdentifier:12221050] PDB:6XED [DatabaseIdentifier:12221043] PDB:1G1H [DatabaseIdentifier:12221061] PDB:2BGD [DatabaseIdentifier:12221032] PDB:8EXK [DatabaseIdentifier:12221060] PDB:2BGE [DatabaseIdentifier:12221012] PDB:7LFO [DatabaseIdentifier:12220991] PDB:6PM8 [DatabaseIdentifier:12221033] PDB:7MM1 [DatabaseIdentifier:12221008] PDB:3EAX [DatabaseIdentifier:12221010] PDB:6OLV [DatabaseIdentifier:12221042] PDB:2QBQ [DatabaseIdentifier:12221039] PDB:6B8X [DatabaseIdentifier:12221016] PDB:2FJM [DatabaseIdentifier:12220988] PDB:2AZR [DatabaseIdentifier:12221063] PDB:7MOW [DatabaseIdentifier:12221038] PDB:6B95 [DatabaseIdentifier:12190438] PDB:3ZMP [DatabaseIdentifier:12220977] PDB:1PYN [DatabaseIdentifier:12221054] PDB:7MNB [DatabaseIdentifier:12195079] PDB:8EXJ [DatabaseIdentifier:12221052] PDB:6XEE [DatabaseIdentifier:12221024] PDB:1PA1 [DatabaseIdentifier:12221056] PDB:7MNA [DatabaseIdentifier:12151716] PDB:8EXN [DatabaseIdentifier:12221067] PDB:1PH0 [DatabaseIdentifier:12221037] PDB:6B8T [DatabaseIdentifier:12221018] PDB:2HNQ [DatabaseIdentifier:12220996] PDB:2ZN7 [DatabaseIdentifier:12221019] PDB:2FJN [DatabaseIdentifier:12221068] PDB:9C66 [DatabaseIdentifier:12221020] PDB:2HNP [DatabaseIdentifier:12221022] PDB:8DU7 [DatabaseIdentifier:12220981] PDB:2NT7 [DatabaseIdentifier:12221021] PDB:7S4F [DatabaseIdentifier:12221065] PDB:7MOV [DatabaseIdentifier:12221062] PDB:7MN9 [DatabaseIdentifier:12220993] PDB:8G6A [DatabaseIdentifier:12221055] PDB:7MNC [DatabaseIdentifier:12221053] PDB:6XEG [DatabaseIdentifier:12142572] PDB:8EXM [DatabaseIdentifier:12221044] PDB:2QBP [DatabaseIdentifier:12221064] PDB:7MOU [DatabaseIdentifier:12220987] PDB:1EEN [DatabaseIdentifier:12221015] PDB:6CWV [DatabaseIdentifier:12221041] PDB:2QBR [DatabaseIdentifier:12220998] PDB:8G68 [DatabaseIdentifier:12221034] PDB:2QBS [DatabaseIdentifier:12221003] PDB:2VEW [DatabaseIdentifier:12221031] PDB:8EYA [DatabaseIdentifier:12220986] PDB:1EEO [DatabaseIdentifier:12221013] PDB:1AAX [DatabaseIdentifier:12221014] PDB:6CWU [DatabaseIdentifier:12221002] PDB:2VEV [DatabaseIdentifier:12190440] PDB:3ZMQ [DatabaseIdentifier:12220994] PDB:6OLQ [DatabaseIdentifier:12220984] PDB:3A5K [DatabaseIdentifier:12221025] PDB:1L8G [DatabaseIdentifier:12221004] PDB:2VEX [DatabaseIdentifier:12221006] PDB:8G65 [DatabaseIdentifier:12221045] PDB:6B90 [DatabaseIdentifier:12221023] PDB:8F88 [DatabaseIdentifier:12221035] PDB:6XEA [DatabaseIdentifier:12221036] PDB:6XE8 [DatabaseIdentifier:12221048] PDB:7MKZ [DatabaseIdentifier:12220995] PDB:8G69 [DatabaseIdentifier:12221005] PDB:2ZMM [DatabaseIdentifier:12220980] PDB:8SKL [DatabaseIdentifier:12221049] PDB:7MN7 [DatabaseIdentifier:12221030] PDB:1I57 [DatabaseIdentifier:12221051] PDB:6XEF [DatabaseIdentifier:12220990] PDB:2NTA [DatabaseIdentifier:12220979] PDB:1GFY [DatabaseIdentifier:12221058] PDB:7MND [DatabaseIdentifier:12220992] PDB:2VEY [DatabaseIdentifier:12221011] PDB:6OMY [DatabaseIdentifier:12221017] PDB:7KEN [DatabaseIdentifier:12221029] PDB:8EYB [DatabaseIdentifier:12215801] PDB:4ZRT [DatabaseIdentifier:12221057] PDB:7MNF [DatabaseIdentifier:12221046] PDB:1G1G [DatabaseIdentifier:12220985] PDB:1NWL [DatabaseIdentifier:12221026] PDB:8EXI [DatabaseIdentifier:12221028] PDB:6B8E [DatabaseIdentifier:12220997] PDB:8G67 [DatabaseIdentifier:12151713] PDB:8EYC [DatabaseIdentifier:12221027] PDB:7KEY [DatabaseIdentifier:12220982] PDB:1ECV [DatabaseIdentifier:12221069] PDB:1OEM [DatabaseIdentifier:12220978] PDB:1LQF [DatabaseIdentifier:12220989] PDB:1NWE [DatabaseIdentifier:12220965] PDB:7GTD [DatabaseIdentifier:12220973] PDB:7FRG [DatabaseIdentifier:12220882] PDB:7GSW [DatabaseIdentifier:12220969] PDB:7FRI [DatabaseIdentifier:12220935] PDB:7GTZ [DatabaseIdentifier:12220930] PDB:7GTT [DatabaseIdentifier:12220956] PDB:7GU1 [DatabaseIdentifier:12220918] PDB:7GSG [DatabaseIdentifier:12220959] PDB:7GU2 [DatabaseIdentifier:12220955] PDB:7GTP [DatabaseIdentifier:12220881] PDB:7FQV [DatabaseIdentifier:12220893] PDB:7GSK [DatabaseIdentifier:12220974] PDB:7GTH [DatabaseIdentifier:12220915] PDB:7GSJ [DatabaseIdentifier:12220953] PDB:7GU4 [DatabaseIdentifier:12220937] PDB:7GU9 [DatabaseIdentifier:12220917] PDB:6PGT [DatabaseIdentifier:12220894] PDB:7GSL [DatabaseIdentifier:12220942] PDB:7GTO [DatabaseIdentifier:12220880] PDB:5KAB [DatabaseIdentifier:12220926] PDB:7GU7 [DatabaseIdentifier:12220913] PDB:5KA0 [DatabaseIdentifier:12220883] PDB:7GT8 [DatabaseIdentifier:12220909] PDB:7GSE [DatabaseIdentifier:12220925] PDB:7GTV [DatabaseIdentifier:12220960] PDB:1PXH [DatabaseIdentifier:12220929] PDB:7FRS [DatabaseIdentifier:12220911] PDB:7GSC [DatabaseIdentifier:12220919] PDB:5KA1 [DatabaseIdentifier:12220895] PDB:5KA8 [DatabaseIdentifier:12220889] PDB:7GSM [DatabaseIdentifier:12220916] PDB:5KA2 [DatabaseIdentifier:12220951] PDB:7FRR [DatabaseIdentifier:12220945] PDB:7GTL [DatabaseIdentifier:12220902] PDB:7GT3 [DatabaseIdentifier:12220968] PDB:6PHS [DatabaseIdentifier:12220967] PDB:7GTE [DatabaseIdentifier:12220966] PDB:7RIN [DatabaseIdentifier:12220898] PDB:7GT2 [DatabaseIdentifier:12220903] PDB:7FQN [DatabaseIdentifier:12220943] PDB:7GU0 [DatabaseIdentifier:12220885] PDB:7FQW [DatabaseIdentifier:12220958] PDB:7GTQ [DatabaseIdentifier:12220887] PDB:7GT9 [DatabaseIdentifier:12220976] PDB:7GTI [DatabaseIdentifier:12220962] PDB:7GTF [DatabaseIdentifier:12220946] PDB:7FRL [DatabaseIdentifier:12220897] PDB:7GSQ [DatabaseIdentifier:12220923] PDB:7GUB [DatabaseIdentifier:12220908] PDB:7GT1 [DatabaseIdentifier:12220952] PDB:7GTS [DatabaseIdentifier:12220901] PDB:7GSR [DatabaseIdentifier:12220891] PDB:7FQM [DatabaseIdentifier:12220949] PDB:7GTR [DatabaseIdentifier:12220975] PDB:7FRH [DatabaseIdentifier:12220910] PDB:7GSF [DatabaseIdentifier:12220948] PDB:7FRQ [DatabaseIdentifier:12220939] PDB:7FRM [DatabaseIdentifier:12220906] PDB:5KA9 [DatabaseIdentifier:12220905] PDB:7GT0 [DatabaseIdentifier:12220950] PDB:7GU3 [DatabaseIdentifier:12220912] PDB:7GSD [DatabaseIdentifier:12220922] PDB:7GUA [DatabaseIdentifier:12220896] PDB:7FQP [DatabaseIdentifier:12220899] PDB:5KA7 [DatabaseIdentifier:12220944] PDB:7FRK [DatabaseIdentifier:12220954] PDB:7FRO [DatabaseIdentifier:12220879] PDB:7GSZ [DatabaseIdentifier:12220940] PDB:7GTN [DatabaseIdentifier:12220914] PDB:7GSI [DatabaseIdentifier:12220961] PDB:7FRE [DatabaseIdentifier:12220936] PDB:7GTX [DatabaseIdentifier:12220920] PDB:7GSH [DatabaseIdentifier:12220900] PDB:7FQQ [DatabaseIdentifier:12220884] PDB:5KAA [DatabaseIdentifier:12220964] PDB:7GTG [DatabaseIdentifier:12220890] PDB:5KA3 [DatabaseIdentifier:12220963] PDB:7FRF [DatabaseIdentifier:12220947] PDB:7GTM [DatabaseIdentifier:12220931] PDB:7GU5 [DatabaseIdentifier:12220938] PDB:7GTY [DatabaseIdentifier:12220934] PDB:7GU6 [DatabaseIdentifier:12220904] PDB:7GSO [DatabaseIdentifier:12220972] PDB:7GTK [DatabaseIdentifier:12220888] PDB:5KA4 [DatabaseIdentifier:12220932] PDB:7FRT [DatabaseIdentifier:12220921] PDB:7GUC [DatabaseIdentifier:12220927] PDB:7GTW [DatabaseIdentifier:12220878] PDB:7FQY [DatabaseIdentifier:12220928] PDB:7GU8 [DatabaseIdentifier:12220907] PDB:7FQO [DatabaseIdentifier:12220933] PDB:7GTU [DatabaseIdentifier:12220970] PDB:7GTJ [DatabaseIdentifier:12220924] PDB:7FRU [DatabaseIdentifier:12220941] PDB:7FRN [DatabaseIdentifier:12220886] PDB:7GSX [DatabaseIdentifier:12220971] PDB:7FRJ [DatabaseIdentifier:12220957] PDB:7FRP [DatabaseIdentifier:12220877] PDB:7GSY [DatabaseIdentifier:12220892] PDB:7GSN [DatabaseIdentifier:12220808] PDB:5QFL [DatabaseIdentifier:12220815] PDB:5QG2 [DatabaseIdentifier:12220867] PDB:7FQU [DatabaseIdentifier:12220823] PDB:1C83 [DatabaseIdentifier:12220812] PDB:5QFN [DatabaseIdentifier:12220818] PDB:1C88 [DatabaseIdentifier:12220822] PDB:1C84 [DatabaseIdentifier:12220777] PDB:1NL9 [DatabaseIdentifier:12220855] PDB:6PG0 [DatabaseIdentifier:12220813] PDB:1ONY [DatabaseIdentifier:12220832] PDB:2B4S [DatabaseIdentifier:12220797] PDB:5QG5 [DatabaseIdentifier:12220806] PDB:5QFJ [DatabaseIdentifier:12220856] PDB:5T19 [DatabaseIdentifier:12220869] PDB:7GT7 [DatabaseIdentifier:12220853] PDB:6PFW [DatabaseIdentifier:12220872] PDB:7GT4 [DatabaseIdentifier:12220857] PDB:5KAD [DatabaseIdentifier:12220782] PDB:5QF0 [DatabaseIdentifier:12220839] PDB:1Q6P [DatabaseIdentifier:12220820] PDB:1C86 [DatabaseIdentifier:12220851] PDB:7GS7 [DatabaseIdentifier:12220837] PDB:1Q6S [DatabaseIdentifier:12220836] PDB:1Q6T [DatabaseIdentifier:12220810] PDB:5QG0 [DatabaseIdentifier:12220871] PDB:7FQR [DatabaseIdentifier:12220785] PDB:5QGF [DatabaseIdentifier:12220843] PDB:1PTY [DatabaseIdentifier:12220825] PDB:1XBO [DatabaseIdentifier:12220799] PDB:5QG8 [DatabaseIdentifier:12220795] PDB:5QG6 [DatabaseIdentifier:12220816] PDB:5QFP [DatabaseIdentifier:12220831] PDB:1WAX [DatabaseIdentifier:12220805] PDB:5QFK [DatabaseIdentifier:12220863] PDB:7GTA [DatabaseIdentifier:12220876] PDB:7FQX [DatabaseIdentifier:12220784] PDB:5QGC [DatabaseIdentifier:12220865] PDB:7GSU [DatabaseIdentifier:12220846] PDB:1QXK [DatabaseIdentifier:12220833] PDB:1Q6M [DatabaseIdentifier:12220864] PDB:7FQT [DatabaseIdentifier:12220850] PDB:7GS9 [DatabaseIdentifier:12220868] PDB:7GSV [DatabaseIdentifier:12220849] PDB:3CWE [DatabaseIdentifier:12220780] PDB:5QF1 [DatabaseIdentifier:12220862] PDB:7GTC [DatabaseIdentifier:12220874] PDB:7GST [DatabaseIdentifier:12220875] PDB:7GT5 [DatabaseIdentifier:12220861] PDB:7GTB [DatabaseIdentifier:12220796] PDB:5QFT [DatabaseIdentifier:12220811] PDB:1ONZ [DatabaseIdentifier:12220838] PDB:1BZC [DatabaseIdentifier:12220829] PDB:6W30 [DatabaseIdentifier:12220848] PDB:7GSB [DatabaseIdentifier:12220854] PDB:1BZJ [DatabaseIdentifier:12220786] PDB:5QGE [DatabaseIdentifier:12220842] PDB:2HB1 [DatabaseIdentifier:12220828] PDB:1A5Y [DatabaseIdentifier:12220789] PDB:5QGA [DatabaseIdentifier:12220788] PDB:5QGB [DatabaseIdentifier:12220830] PDB:1PTT [DatabaseIdentifier:12220870] PDB:6PHA [DatabaseIdentifier:12220802] PDB:5QFY [DatabaseIdentifier:12220783] PDB:5QGD [DatabaseIdentifier:12220778] PDB:5QEM [DatabaseIdentifier:12220792] PDB:5QFR [DatabaseIdentifier:12220804] PDB:5QG9 [DatabaseIdentifier:12220844] PDB:1PTV [DatabaseIdentifier:12220841] PDB:8XOY [DatabaseIdentifier:12220866] PDB:7GT6 [DatabaseIdentifier:12220791] PDB:5QG4 [DatabaseIdentifier:12220817] PDB:5QG1 [DatabaseIdentifier:12220794] PDB:5QFU [DatabaseIdentifier:12220834] PDB:1Q6J [DatabaseIdentifier:12220793] PDB:5QG3 [DatabaseIdentifier:12220824] PDB:1JF7 [DatabaseIdentifier:12220798] PDB:5QFW [DatabaseIdentifier:12220821] PDB:1C85 [DatabaseIdentifier:12220779] PDB:5QEP [DatabaseIdentifier:12220801] PDB:5QG7 [DatabaseIdentifier:12220858] PDB:5KAC [DatabaseIdentifier:12220840] PDB:1Q6N [DatabaseIdentifier:12220860] PDB:3D9C [DatabaseIdentifier:12220873] PDB:7FQS [DatabaseIdentifier:12220809] PDB:5QFO [DatabaseIdentifier:12220790] PDB:5QFS [DatabaseIdentifier:12220781] PDB:5QEO [DatabaseIdentifier:12220845] PDB:1PTU [DatabaseIdentifier:12220803] PDB:5QFX [DatabaseIdentifier:12220827] PDB:1NNY [DatabaseIdentifier:12220847] PDB:7GSA [DatabaseIdentifier:12220807] PDB:5QFM [DatabaseIdentifier:12220814] PDB:5QFQ [DatabaseIdentifier:12220800] PDB:5QFV [DatabaseIdentifier:12220835] PDB:1BZH [DatabaseIdentifier:12220826] PDB:1NO6 [DatabaseIdentifier:12220819] PDB:1C87 [DatabaseIdentifier:12220859] PDB:7FQZ [DatabaseIdentifier:12220787] PDB:5QFZ [DatabaseIdentifier:12220852] PDB:7GS8 [DatabaseIdentifier:12220738] PDB:5QFC [DatabaseIdentifier:12220757] PDB:5QF5 [DatabaseIdentifier:12220704] PDB:5QEF [DatabaseIdentifier:12220700] PDB:5QEA [DatabaseIdentifier:12220771] PDB:5QEI [DatabaseIdentifier:12220716] PDB:5QE1 [DatabaseIdentifier:12220691] PDB:2F6T [DatabaseIdentifier:12220769] PDB:5QF8 [DatabaseIdentifier:12220752] PDB:5QER [DatabaseIdentifier:12220773] PDB:3QKP [DatabaseIdentifier:12220731] PDB:5QDK [DatabaseIdentifier:12220732] PDB:5QDJ [DatabaseIdentifier:12220687] PDB:2F6Y [DatabaseIdentifier:12220735] PDB:5QDO [DatabaseIdentifier:12220765] PDB:5QF6 [DatabaseIdentifier:12220710] PDB:5QE9 [DatabaseIdentifier:12220725] PDB:5QDW [DatabaseIdentifier:12220701] PDB:5QED [DatabaseIdentifier:12220764] PDB:5QEU [DatabaseIdentifier:12220745] PDB:5QFH [DatabaseIdentifier:12220723] PDB:5QDT [DatabaseIdentifier:12220711] PDB:4BJO [DatabaseIdentifier:12220724] PDB:5QE5 [DatabaseIdentifier:12220718] PDB:5QE4 [DatabaseIdentifier:12220713] PDB:5QDQ [DatabaseIdentifier:12220693] PDB:5QDF [DatabaseIdentifier:12220767] PDB:5QF9 [DatabaseIdentifier:12220696] PDB:2F71 [DatabaseIdentifier:12220702] PDB:1SUG [DatabaseIdentifier:12220733] PDB:5QDM [DatabaseIdentifier:12220768] PDB:5QEW [DatabaseIdentifier:12220762] PDB:5QF7 [DatabaseIdentifier:12220697] PDB:2F70 [DatabaseIdentifier:12220714] PDB:5QE2 [DatabaseIdentifier:12220753] PDB:5QF3 [DatabaseIdentifier:12220737] PDB:5QDN [DatabaseIdentifier:12220761] PDB:5QEV [DatabaseIdentifier:12220743] PDB:5QFF [DatabaseIdentifier:12220740] PDB:5QFE [DatabaseIdentifier:12220708] PDB:5QDY [DatabaseIdentifier:12220719] PDB:5QDR [DatabaseIdentifier:12220770] PDB:5QEJ [DatabaseIdentifier:12220685] PDB:1T48 [DatabaseIdentifier:12220683] PDB:3SME [DatabaseIdentifier:12220709] PDB:5QDX [DatabaseIdentifier:12220747] PDB:5QEY [DatabaseIdentifier:12220756] PDB:5QET [DatabaseIdentifier:12220775] PDB:3QKQ [DatabaseIdentifier:12220744] PDB:5QFI [DatabaseIdentifier:12220686] PDB:1T49 [DatabaseIdentifier:12220736] PDB:5QE0 [DatabaseIdentifier:12220699] PDB:5QEB [DatabaseIdentifier:12220746] PDB:5QEZ [DatabaseIdentifier:12220689] PDB:2F6V [DatabaseIdentifier:12220739] PDB:5QFB [DatabaseIdentifier:12220748] PDB:5K9V [DatabaseIdentifier:12220727] PDB:5QDV [DatabaseIdentifier:12220758] PDB:4I8N [DatabaseIdentifier:12220763] PDB:3EU0 [DatabaseIdentifier:12220751] PDB:5QFA [DatabaseIdentifier:12220755] PDB:5QF2 [DatabaseIdentifier:12220728] PDB:5QE7 [DatabaseIdentifier:12220692] PDB:5QDG [DatabaseIdentifier:12220742] PDB:5QFG [DatabaseIdentifier:12220759] PDB:5QES [DatabaseIdentifier:12220705] PDB:5QEE [DatabaseIdentifier:12220684] PDB:1T4J [DatabaseIdentifier:12220717] PDB:5QDS [DatabaseIdentifier:12220730] PDB:5QDH [DatabaseIdentifier:12220721] PDB:5QDU [DatabaseIdentifier:12220703] PDB:5QEC [DatabaseIdentifier:12220690] PDB:5QDE [DatabaseIdentifier:12220749] PDB:1Q1M [DatabaseIdentifier:12220695] PDB:2F6F [DatabaseIdentifier:12220715] PDB:5QDP [DatabaseIdentifier:12220707] PDB:5QEG [DatabaseIdentifier:12220741] PDB:5QFD [DatabaseIdentifier:12220772] PDB:5QEL [DatabaseIdentifier:12220698] PDB:2B07 [DatabaseIdentifier:12220729] PDB:5QDI [DatabaseIdentifier:12220688] PDB:2F6W [DatabaseIdentifier:12220720] PDB:5QE3 [DatabaseIdentifier:12220760] PDB:5QF4 [DatabaseIdentifier:12220754] PDB:5QEQ [DatabaseIdentifier:12220694] PDB:2F6Z [DatabaseIdentifier:12220766] PDB:5QEX [DatabaseIdentifier:12220712] PDB:5QDZ [DatabaseIdentifier:12220750] PDB:5K9W [DatabaseIdentifier:12220774] PDB:5QEK [DatabaseIdentifier:12220722] PDB:5QE6 [DatabaseIdentifier:12220706] PDB:5QEH [DatabaseIdentifier:12220734] PDB:5QDL [DatabaseIdentifier:12220776] PDB:5QEN [DatabaseIdentifier:12220726] PDB:5QE8 [DatabaseIdentifier:12131759] OpenTargets:ENSG00000196396 [DatabaseIdentifier:11850128] IntEnz:3.1.3.48 [DatabaseIdentifier:11847092] HPA:ENSG00000196396-PTPN1 [DatabaseIdentifier:11830990] HMDB Protein:HMDBP08931 [DatabaseIdentifier:11810044] GlyGen:P18031 [DatabaseIdentifier:11794108] GeneCards:PTPN1 [DatabaseIdentifier:11780525] Guide to Pharmacology - Targets:2976 [DatabaseIdentifier:11705468] ENSEMBL:ENST00000371621 [DatabaseIdentifier:11582769] ENSEMBL:ENSP00000360683
databaseName	UniProt
dbId	62423
description	recommendedName: Tyrosine-protein phosphatase non-receptor type 1 ecNumber: 3.1.3.48 alternativeName: Protein-tyrosine phosphatase 1B shortName: PTP-1B
displayName	UniProt:P18031 PTPN1
geneName	PTPN1 PTP1B
identifier	P18031
isSequenceChanged	false
keyword	3D-structure Acetylation Direct protein sequencing Endoplasmic reticulum Hydrolase Membrane Oxidation Phosphoprotein Protein phosphatase Proteomics identification Reference proteome S-nitrosylation
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	PTPN1
otherIdentifier	11717146_at 11717147_a_at 16914844 16914859 202716_PM_at 202716_at 3888722 3888723 3888724 3888725 3888747 3888751 3888753 3888755 3888761 3888762 3888764 3888766 3888767 3888769 3888770 3888772 3888773 3888774 3888775 3888776 3888777 3888778 3888783 3888785 40137_at 5770 588_at 591_s_at 8063394 A_14_P115470 A_23_P338890 GE57927 GO:0003084 GO:0003723 GO:0003824 GO:0004721 GO:0004725 GO:0004726 GO:0005158 GO:0005515 GO:0005737 GO:0005759 GO:0005768 GO:0005769 GO:0005783 GO:0005789 GO:0005829 GO:0005886 GO:0006470 GO:0008270 GO:0008285 GO:0008286 GO:0009966 GO:0009968 GO:0010460 GO:0010666 GO:0010812 GO:0010977 GO:0012505 GO:0016020 GO:0016311 GO:0016787 GO:0016791 GO:0019899 GO:0019901 GO:0030036 GO:0030061 GO:0030100 GO:0030162 GO:0030948 GO:0030968 GO:0030971 GO:0031667 GO:0031904 GO:0032869 GO:0032991 GO:0033157 GO:0034620 GO:0034976 GO:0035335 GO:0035791 GO:0036120 GO:0036498 GO:0038020 GO:0043407 GO:0044344 GO:0045296 GO:0046330 GO:0046626 GO:0046627 GO:0046875 GO:0051721 GO:0051898 GO:0060338 GO:0060397 GO:0070373 GO:0071456 GO:0071732 GO:0097443 GO:0097706 GO:0098554 GO:0098794 GO:0098978 GO:0140096 GO:0150052 GO:1902202 GO:1902236 GO:1903896 GO:1903898 GO:1904385 GO:1904753 GO:1990090 GO:1990776 GO:2000353 GO:2000646 HMNXSV003018706 ILMN_1681591 M31724_at M33684_s_at PH_hs_0025079 TC20000403.hg TC20000405.hg g4506288_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9815895] PTPN1 [endosome membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-210625] PTPN1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000196396] ENSEMBL:ENSG00000196396 PTPN1 [ReferenceDNASequence:12693471] UCSC:P18031 PTPN1 [ReferenceDNASequence:12116191] OMIM:176885 PTPN1 [ReferenceDNASequence:12060879] NCBI Gene:5770 PTPN1 [ReferenceDNASequence:11976786] Monarch:5770 PTPN1 [ReferenceDNASequence:11887079] KEGG:hsa:5770 PTPN1 [ReferenceDNASequence:11825803] HGNC:9642 PTPN1 [ReferenceDNASequence:11429144] dbSNP Gene:5770 PTPN1 [ReferenceDNASequence:11422779] CTD Gene:5770 PTPN1 [ReferenceDNASequence:11393205] COSMIC - genes:PTPN1 PTPN1 [ReferenceDNASequence:11346997] BioGPS Gene:5770 PTPN1
referenceTranscript	[ReferenceRNASequence:12569882] RefSeq:NM_001278618.1 PTPN1 [ReferenceRNASequence:12569883] RefSeq:NM_002827.4 PTPN1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PTN1_HUMAN Q5TGD8 Q9BQV9 Q9NQQ4
sequenceLength	435
species	[Species:48887] Homo sapiens
stId	uniprot:P18031
url	http://purl.uniprot.org/uniprot/P18031

UniProt:P18031 PTPN1 Show undefined attributes

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