UniProt:P17936 IGFBP3

chain
  • signal peptide:1-27
  • chain:28-291
checksum A9682065AB266586
comment
  • FUNCTION Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028).SUBUNIT Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS) (PubMed:35907924). Interacts with humanin; humanin competes with importin KPNB1 for binding to IGFBP3, blocking IGFBP3 nuclear import and IGFBP3-mediated apoptosis (PubMed:14561895, PubMed:19623253, PubMed:26216267). Interacts with TMEM219. Interacts with RXRA; this interaction modulates the transcriptional activity of RXRA (PubMed:10874028). Interacts with LRP1; this interaction mediates cell growth inhibition independent of IGF1 (PubMed:9252371).INTERACTION Expressed by most tissues. Present in plasma.DEVELOPMENTAL STAGE IGFBP3 levels are higher during extrauterine life and peak during puberty.INDUCTION Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters.DOMAIN The thyroglobulin type-1 domain mediates interaction with HN.PTM Phosphorylated by FAM20C in the extracellular medium. Phosphorylated by CK2; resulting in decreased nuclear localization (PubMed:19556345).
created [InstanceEdit:381505] May, B, 2008-11-19 20:29:10
crossReference
databaseName UniProt
dbId 381525
description
  • recommendedName: Insulin-like growth factor-binding protein 3 shortName: IBP-3 shortName: IGF-binding protein 3 shortName: IGFBP-3
displayName UniProt:P17936 IGFBP3
geneName
  • IGFBP3
  • IBP3
identifier P17936
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Apoptosis
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Growth factor binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • IGFBP3
otherIdentifier
  • 11721135_s_at
  • 11749912_x_at
  • 1586_at
  • 17057478
  • 210095_PM_s_at
  • 210095_s_at
  • 212143_PM_s_at
  • 212143_s_at
  • 3049293
  • 3049294
  • 3049295
  • 3049296
  • 3049297
  • 3049298
  • 3049299
  • 3049300
  • 3049301
  • 3049302
  • 3049303
  • 3049304
  • 3049305
  • 3049306
  • 3049307
  • 3049308
  • 3049309
  • 3049310
  • 3049311
  • 3486
  • 37319_at
  • 8139488
  • A_23_P215634
  • A_24_P320699
  • GE59912
  • GO:0000165
  • GO:0001558
  • GO:0001649
  • GO:0001933
  • GO:0001968
  • GO:0005515
  • GO:0005520
  • GO:0005576
  • GO:0005615
  • GO:0005634
  • GO:0005788
  • GO:0006468
  • GO:0006915
  • GO:0008160
  • GO:0008285
  • GO:0009968
  • GO:0010906
  • GO:0014912
  • GO:0016942
  • GO:0019838
  • GO:0030154
  • GO:0031994
  • GO:0031995
  • GO:0040008
  • GO:0042567
  • GO:0043065
  • GO:0043410
  • GO:0043567
  • GO:0043568
  • GO:0044342
  • GO:0045663
  • GO:0046872
  • GO:0048662
  • GO:0098772
  • HMNXSV003031537
  • Hs.77326.1.S2_3p_a_at
  • ILMN_1746085
  • ILMN_2396875
  • M35878_at
  • PH_hs_0036058
  • TC07001355.hg
  • g183115_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IBP3_HUMAN
  • A4D2F5
  • D3DVM0
  • Q2V509
  • Q6P1M6
  • Q9UCL4
sequenceLength 291
species [Species:48887] Homo sapiens
stId uniprot:P17936
url http://purl.uniprot.org/uniprot/P17936

Referrals

(referenceEntity)
(referenceSequence)
(interactor)
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