FUNCTION HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.SUBUNIT Interacts with HIPK2 (By similarity).INTERACTION Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.PTM HMG-Y is not methylated.PTM Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.MASS SPECTROMETRY With 1 acetyl and 2 phosphate groups. The measured range is 2-107.MASS SPECTROMETRY With 1 acetyl and 3 phosphate groups. The measured range is 2-107.MASS SPECTROMETRY With 1 acetyl, 1 methyl and 2 phosphate groups. The measured range is 2-107.MASS SPECTROMETRY With 1 acetyl, 1 methyl and 3 phosphate groups. The measured range is 2-107.MASS SPECTROMETRY With 1 acetyl, 2 methyl and 2 phosphate groups. The measured range is 2-107.MASS SPECTROMETRY With 1 acetyl, 2 methyl and 3 phosphate groups. The measured range is 2-107.DISEASE A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.SIMILARITY Belongs to the HMGA family.
recommendedName: High mobility group protein HMG-I/HMG-Y shortName: HMG-I(Y) alternativeName: High mobility group AT-hook protein 1 shortName: High mobility group protein A1 alternativeName: High mobility group protein R
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