Reactome | UniProt:P17076 RPL8A

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UniProt:P17076 RPL8A Show undefined attributes

chain	initiator methionine:1 chain:2-256
checksum	E3C8537D8683C905
comment	FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.SUBUNIT Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:22096102, PubMed:9559554).SUBCELLULAR LOCATION Present with 238000 molecules/cell in log phase SD medium.MISCELLANEOUS There are 2 genes for eL8 in yeast.SIMILARITY Belongs to the eukaryotic ribosomal protein eL8 family.
crossReference	[DatabaseIdentifier:12142304] PDB:5LYB [DatabaseIdentifier:12430211] RefSeq:NP_011830.1 [DatabaseIdentifier:12253272] PRO:P17076 [DatabaseIdentifier:12144995] PDB:6YLX [DatabaseIdentifier:12144985] PDB:8AGW [DatabaseIdentifier:12142407] PDB:6T4Q [DatabaseIdentifier:12145010] PDB:6N8N [DatabaseIdentifier:12144983] PDB:5T62 [DatabaseIdentifier:12142423] PDB:5ON6 [DatabaseIdentifier:12144989] PDB:8AGT [DatabaseIdentifier:12142420] PDB:8CMJ [DatabaseIdentifier:12145006] PDB:6N8M [DatabaseIdentifier:12145011] PDB:7OH3 [DatabaseIdentifier:12144991] PDB:6OIG [DatabaseIdentifier:12142403] PDB:5DGE [DatabaseIdentifier:12145001] PDB:6M62 [DatabaseIdentifier:12145007] PDB:6N8L [DatabaseIdentifier:12144997] PDB:6S05 [DatabaseIdentifier:12142391] PDB:8XU8 [DatabaseIdentifier:12144987] PDB:6YLY [DatabaseIdentifier:12142404] PDB:5DGF [DatabaseIdentifier:12142424] PDB:5TGM [DatabaseIdentifier:12145005] PDB:6N8J [DatabaseIdentifier:12144999] PDB:5T6R [DatabaseIdentifier:12142394] PDB:5TGA [DatabaseIdentifier:12151498] PDB:5Z3G [DatabaseIdentifier:12145008] PDB:6N8O [DatabaseIdentifier:12144988] PDB:8BIP [DatabaseIdentifier:12144998] PDB:7UQZ [DatabaseIdentifier:12150880] PDB:6C0F [DatabaseIdentifier:12144993] PDB:5APO [DatabaseIdentifier:12145000] PDB:8HFR [DatabaseIdentifier:12144996] PDB:7OF1 [DatabaseIdentifier:12152564] PDB:8PFR [DatabaseIdentifier:12145002] PDB:8BJQ [DatabaseIdentifier:12142389] PDB:8CKU [DatabaseIdentifier:12144992] PDB:7AZY [DatabaseIdentifier:12144994] PDB:5APN [DatabaseIdentifier:12144986] PDB:8AGZ [DatabaseIdentifier:12144990] PDB:8AGU [DatabaseIdentifier:12144984] PDB:8AGV [DatabaseIdentifier:12151499] PDB:6CB1 [DatabaseIdentifier:12142383] PDB:8P4V [DatabaseIdentifier:12145012] PDB:5JCS [DatabaseIdentifier:12145004] PDB:6N8K [DatabaseIdentifier:12153840] PDB:7OSA [DatabaseIdentifier:12144981] PDB:7UQB [DatabaseIdentifier:12142334] PDB:4V8Y [DatabaseIdentifier:12150862] PDB:7NAC [DatabaseIdentifier:12144977] PDB:7TOP [DatabaseIdentifier:12142413] PDB:4U4Q [DatabaseIdentifier:12142300] PDB:6I7O [DatabaseIdentifier:12144971] PDB:6QIK [DatabaseIdentifier:12142322] PDB:9F9S [DatabaseIdentifier:12144962] PDB:6R84 [DatabaseIdentifier:12140535] PDB:8Z71 [DatabaseIdentifier:12142315] PDB:4U6F [DatabaseIdentifier:12142421] PDB:8CEH [DatabaseIdentifier:12140531] PDB:7B7D [DatabaseIdentifier:12142356] PDB:8ZGY [DatabaseIdentifier:12139467] PDB:4V91 [DatabaseIdentifier:12142397] PDB:4U3M [DatabaseIdentifier:12144975] PDB:7UOO [DatabaseIdentifier:12142314] PDB:8CGN [DatabaseIdentifier:12142312] PDB:6Q8Y [DatabaseIdentifier:12144963] PDB:6R87 [DatabaseIdentifier:12144966] PDB:6RI5 [DatabaseIdentifier:12142409] PDB:4U4O [DatabaseIdentifier:12142347] PDB:3J6X [DatabaseIdentifier:12142422] PDB:4U3U [DatabaseIdentifier:12142330] PDB:5TBW [DatabaseIdentifier:12144964] PDB:6R86 [DatabaseIdentifier:12142320] PDB:5DAT [DatabaseIdentifier:12142290] PDB:4V7R [DatabaseIdentifier:12142325] PDB:6HHQ [DatabaseIdentifier:12142344] PDB:7MPI [DatabaseIdentifier:12144980] PDB:7TOO [DatabaseIdentifier:12142341] PDB:7MPJ [DatabaseIdentifier:12142308] PDB:4U4Z [DatabaseIdentifier:12142338] PDB:8Z70 [DatabaseIdentifier:12142398] PDB:8CDR [DatabaseIdentifier:12142416] PDB:4U4R [DatabaseIdentifier:12142305] PDB:4U4U [DatabaseIdentifier:12144968] PDB:6RZZ [DatabaseIdentifier:12154598] PDB:7R6K [DatabaseIdentifier:12142301] PDB:5NDW [DatabaseIdentifier:12142313] PDB:5DC3 [DatabaseIdentifier:12142298] PDB:5MC6 [DatabaseIdentifier:12142411] PDB:4U51 [DatabaseIdentifier:12142399] PDB:4U3N [DatabaseIdentifier:12144976] PDB:7V08 [DatabaseIdentifier:12142299] PDB:5NDV [DatabaseIdentifier:12150882] PDB:7R7A [DatabaseIdentifier:12142346] PDB:3J78 [DatabaseIdentifier:12142345] PDB:6SNT [DatabaseIdentifier:12142396] PDB:8PNN [DatabaseIdentifier:12142410] PDB:4U50 [DatabaseIdentifier:12142371] PDB:8ZGR [DatabaseIdentifier:12142418] PDB:5M1J [DatabaseIdentifier:12142307] PDB:4U4Y [DatabaseIdentifier:12144967] PDB:8AAF [DatabaseIdentifier:12142336] PDB:4V8Z [DatabaseIdentifier:12142292] PDB:8CG8 [DatabaseIdentifier:12142319] PDB:4V88 [DatabaseIdentifier:12151495] PDB:7R6Q [DatabaseIdentifier:12144965] PDB:6HD7 [DatabaseIdentifier:12142368] PDB:6TB3 [DatabaseIdentifier:12144970] PDB:8Y0U [DatabaseIdentifier:12150860] PDB:7NAD [DatabaseIdentifier:12142425] PDB:7ZUX [DatabaseIdentifier:12142402] PDB:5FCI [DatabaseIdentifier:12142353] PDB:8ZHC [DatabaseIdentifier:12142357] PDB:3J77 [DatabaseIdentifier:12142343] PDB:7NRD [DatabaseIdentifier:12144973] PDB:6FT6 [DatabaseIdentifier:12142303] PDB:4U55 [DatabaseIdentifier:12140964] PDB:4V5Z [DatabaseIdentifier:12150868] PDB:7U0H [DatabaseIdentifier:12150867] PDB:7R72 [DatabaseIdentifier:12142426] PDB:7ZUW [DatabaseIdentifier:12142419] PDB:4V6I [DatabaseIdentifier:12142339] PDB:8CIV [DatabaseIdentifier:12142342] PDB:7NRC [DatabaseIdentifier:12142372] PDB:8ZH3 [DatabaseIdentifier:12142405] PDB:8CF5 [DatabaseIdentifier:12144969] PDB:4V7F [DatabaseIdentifier:12142395] PDB:5FCJ [DatabaseIdentifier:12142332] PDB:8K82 [DatabaseIdentifier:12142327] PDB:5MEI [DatabaseIdentifier:12142348] PDB:3J6Y [DatabaseIdentifier:12144978] PDB:6YLH [DatabaseIdentifier:12142306] PDB:4U56 [DatabaseIdentifier:12144972] PDB:4V8T [DatabaseIdentifier:12142415] PDB:7ZW0 [DatabaseIdentifier:12142414] PDB:4U52 [DatabaseIdentifier:12142417] PDB:4U53 [DatabaseIdentifier:12142351] PDB:8ZHB [DatabaseIdentifier:12142401] PDB:8CDL [DatabaseIdentifier:12144979] PDB:6YLG [DatabaseIdentifier:12153839] PDB:7OSM [DatabaseIdentifier:12142412] PDB:5NDG [DatabaseIdentifier:12142408] PDB:4U4N [DatabaseIdentifier:12144982] PDB:8AGX [DatabaseIdentifier:12142321] PDB:6TNU [DatabaseIdentifier:12144974] PDB:3JCT [DatabaseIdentifier:12142367] PDB:8T3F [DatabaseIdentifier:12142382] PDB:6Z6K [DatabaseIdentifier:12150879] PDB:7OHU [DatabaseIdentifier:12142311] PDB:8UT0 [DatabaseIdentifier:12142375] PDB:8T2X [DatabaseIdentifier:12150874] PDB:7OHS [DatabaseIdentifier:12140536] PDB:8YLR [DatabaseIdentifier:12151497] PDB:8E5T [DatabaseIdentifier:12150866] PDB:6EM1 [DatabaseIdentifier:12150873] PDB:7OHR [DatabaseIdentifier:12142297] PDB:8P85 [DatabaseIdentifier:12150870] PDB:7OHX [DatabaseIdentifier:12142335] PDB:7N8B [DatabaseIdentifier:12142329] PDB:6T7I [DatabaseIdentifier:12142293] PDB:5JUP [DatabaseIdentifier:12144955] PDB:6QT0 [DatabaseIdentifier:12142359] PDB:8T3A [DatabaseIdentifier:12150875] PDB:7OHP [DatabaseIdentifier:12145958] PDB:8V84 [DatabaseIdentifier:12150869] PDB:6EM5 [DatabaseIdentifier:12142379] PDB:8EVP [DatabaseIdentifier:12142340] PDB:8T30 [DatabaseIdentifier:12144959] PDB:7ZS5 [DatabaseIdentifier:12142309] PDB:6SV4 [DatabaseIdentifier:12142365] PDB:8EVR [DatabaseIdentifier:12142354] PDB:6GQ1 [DatabaseIdentifier:12142350] PDB:8EWC [DatabaseIdentifier:12142328] PDB:8UTI [DatabaseIdentifier:12142318] PDB:6S47 [DatabaseIdentifier:12142393] PDB:8K2D [DatabaseIdentifier:12144960] PDB:6QTZ [DatabaseIdentifier:12142366] PDB:8T3E [DatabaseIdentifier:12142392] PDB:6GQB [DatabaseIdentifier:12152563] PDB:4V4B [DatabaseIdentifier:12142363] PDB:8EVQ [DatabaseIdentifier:12151494] PDB:6EM3 [DatabaseIdentifier:12150861] PDB:7BTB [DatabaseIdentifier:12142337] PDB:7ZPQ [DatabaseIdentifier:12153837] PDB:7RR5 [DatabaseIdentifier:12140532] PDB:8YLD [DatabaseIdentifier:12142302] PDB:5JUO [DatabaseIdentifier:12142384] PDB:6Z6J [DatabaseIdentifier:12142316] PDB:8BN3 [DatabaseIdentifier:12152561] PDB:8P8N [DatabaseIdentifier:12142380] PDB:7ZRS [DatabaseIdentifier:11500845] ENSEMBL:YHL033C [DatabaseIdentifier:11611157] ENSEMBL:YHL033C [DatabaseIdentifier:11733856] ENSEMBL:YHL033C_mRNA [DatabaseIdentifier:12150871] PDB:7OHY [DatabaseIdentifier:12142377] PDB:8T2Y [DatabaseIdentifier:12142295] PDB:5JUU [DatabaseIdentifier:12150876] PDB:7OHV [DatabaseIdentifier:12144952] PDB:8P8U [DatabaseIdentifier:12142378] PDB:5OBM [DatabaseIdentifier:12142323] PDB:6T83 [DatabaseIdentifier:12152562] PDB:8P8M [DatabaseIdentifier:12142374] PDB:6WOO [DatabaseIdentifier:12150864] PDB:6ELZ [DatabaseIdentifier:12142349] PDB:8EWB [DatabaseIdentifier:12145960] PDB:8V87 [DatabaseIdentifier:12142324] PDB:8EUB [DatabaseIdentifier:12142386] PDB:8BQX [DatabaseIdentifier:12150877] PDB:7OHW [DatabaseIdentifier:12142361] PDB:8T3B [DatabaseIdentifier:12142352] PDB:8BQD [DatabaseIdentifier:12144961] PDB:7Z34 [DatabaseIdentifier:12142358] PDB:8EVS [DatabaseIdentifier:12142326] PDB:6T7T [DatabaseIdentifier:12144954] PDB:7UG6 [DatabaseIdentifier:12144957] PDB:5H4P [DatabaseIdentifier:12142360] PDB:8EVT [DatabaseIdentifier:12142331] PDB:5I4L [DatabaseIdentifier:12142296] PDB:5JUT [DatabaseIdentifier:12150863] PDB:8V83 [DatabaseIdentifier:12142370] PDB:8T3D [DatabaseIdentifier:12142385] PDB:8CCS [DatabaseIdentifier:12142388] PDB:6GQV [DatabaseIdentifier:12142333] PDB:8P9A [DatabaseIdentifier:12142369] PDB:8T3C [DatabaseIdentifier:12151496] PDB:6EM4 [DatabaseIdentifier:12142294] PDB:5JUS [DatabaseIdentifier:12144956] PDB:9F58 [DatabaseIdentifier:12144958] PDB:9OFV [DatabaseIdentifier:12144951] PDB:7OHQ [DatabaseIdentifier:12144953] PDB:5GAK [DatabaseIdentifier:12150872] PDB:7BT6 [DatabaseIdentifier:12142381] PDB:8T2Z
databaseName	UniProt
dbId	100234
description	recommendedName: fullName evidence="7"Large ribosomal subunit protein eL8A alternativeName: fullName evidence="8"60S ribosomal protein L8-A alternativeName: L4 alternativeName: L4-2 alternativeName: L7a-1 alternativeName: Maintenance of killer protein 7 alternativeName: RP6 alternativeName: YL5
displayName	UniProt:P17076 RPL8A
geneName	RPL8A MAK7 RPL4A YHL033C
identifier	P17076
isSequenceChanged	false
keyword	3D-structure Cytoplasm Direct protein sequencing Reference proteome Ribonucleoprotein Ribosomal protein
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPL8A
otherIdentifier	856352 GO:0000470 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005575 GO:0005737 GO:0005829 GO:0005840 GO:0006364 GO:0022625 GO:0042254 GO:1990904
physicalEntity	[EntityWithAccessionedSequence:R-SCE-9633150] RPL8A [cytosol] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11366153] BioGPS Gene:856352 RPL8A [ReferenceDNASequence:12756798] UCSC:P17076 RPL8A [ReferenceDNASequence:11904602] KEGG:sce:YHL033C RPL8A [ReferenceDNASequence:11995942] Monarch:856352 RPL8A [ReferenceDNASequence:12080035] NCBI Gene:856352 RPL8A
referenceTranscript	[ReferenceRNASequence:12611729] RefSeq:NM_001179113.1 RPL8A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RL8A_YEAST D3DKT5
sequenceLength	256
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P17076
url	http://purl.uniprot.org/uniprot/P17076

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-SCE-9633150] RPL8A [cytosol]

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