Reactome | UniProt:P16471 PRLR

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UniProt:P16471 PRLR Show undefined attributes

chain	signal peptide:1-24 chain:25-622
checksum	DB7FD0328608C787
comment	FUNCTION This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.SUBUNIT Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.INTERACTION Expressed in breast, placenta, kidney, liver and pancreas.DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Soluble isoform that appears specific for the BT-474 breast cancer cell line.MISCELLANEOUS Includes exon 11. Does not transduce prolactin signaling.MISCELLANEOUS Produced by deletion of part of exon 10 and frameshift.MISCELLANEOUS Does not transduce prolactin signaling.MISCELLANEOUS Splices from exon 7 to exon 11.MISCELLANEOUS SF1b with deletion of exon 4. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the type I cytokine receptor family. Type 1 subfamily.
crossReference	[DatabaseIdentifier:12152508] PDB:3NCB [DatabaseIdentifier:12815438] ZINC target:P16471 [DatabaseIdentifier:12812086] ZINC - Substances:PRLR_HUMAN [DatabaseIdentifier:12810160] ZINC - Predictions - Purchasable:PRLR_HUMAN [DatabaseIdentifier:12400976] RefSeq:XP_054208914.1 [DatabaseIdentifier:12400978] RefSeq:XP_054208913.1 [DatabaseIdentifier:12400971] RefSeq:NP_001191245.1 [DatabaseIdentifier:12400973] RefSeq:NP_001191247.1 [DatabaseIdentifier:12400983] RefSeq:NP_001191243.1 [DatabaseIdentifier:12400974] RefSeq:NP_001191246.1 [DatabaseIdentifier:12400975] RefSeq:XP_054208915.1 [DatabaseIdentifier:12400981] RefSeq:XP_047273344.1 [DatabaseIdentifier:12400977] RefSeq:NP_000940.1 [DatabaseIdentifier:12400979] RefSeq:XP_011512370.1 [DatabaseIdentifier:12400982] RefSeq:XP_006714547.1 [DatabaseIdentifier:12400972] RefSeq:NP_001191244.1 [DatabaseIdentifier:12400980] RefSeq:XP_047273346.1 [DatabaseIdentifier:12281488] Pharos - Targets:P16471 [DatabaseIdentifier:12238945] PRO:P16471 [DatabaseIdentifier:12152513] PDB:3NCE [DatabaseIdentifier:12152519] PDB:3MZG [DatabaseIdentifier:12152517] PDB:2LFG [DatabaseIdentifier:12152511] PDB:3NCC [DatabaseIdentifier:12152510] PDB:3N0P [DatabaseIdentifier:12152514] PDB:3NCF [DatabaseIdentifier:12152518] PDB:3D48 [DatabaseIdentifier:12152515] PDB:2N7I [DatabaseIdentifier:12152509] PDB:1BP3 [DatabaseIdentifier:11486846] ENSEMBL:ENSG00000113494 [DatabaseIdentifier:11591179] ENSEMBL:ENSP00000231423 [DatabaseIdentifier:11591186] ENSEMBL:ENSP00000309008 [DatabaseIdentifier:11591184] ENSEMBL:ENSP00000311613 [DatabaseIdentifier:11591182] ENSEMBL:ENSP00000422935 [DatabaseIdentifier:11591181] ENSEMBL:ENSP00000441813 [DatabaseIdentifier:11591180] ENSEMBL:ENSP00000422556 [DatabaseIdentifier:11591183] ENSEMBL:ENSP00000482954 [DatabaseIdentifier:11591178] ENSEMBL:ENSP00000424841 [DatabaseIdentifier:11591188] ENSEMBL:ENSP00000482689 [DatabaseIdentifier:11591185] ENSEMBL:ENSP00000425300 [DatabaseIdentifier:11591187] ENSEMBL:ENSP00000484768 [DatabaseIdentifier:11713879] ENSEMBL:ENST00000618457 [DatabaseIdentifier:11713881] ENSEMBL:ENST00000348262 [DatabaseIdentifier:11713885] ENSEMBL:ENST00000310101 [DatabaseIdentifier:11713883] ENSEMBL:ENST00000231423 [DatabaseIdentifier:11713882] ENSEMBL:ENST00000511486 [DatabaseIdentifier:11713886] ENSEMBL:ENST00000509140 [DatabaseIdentifier:11713884] ENSEMBL:ENST00000514088 [DatabaseIdentifier:11713887] ENSEMBL:ENST00000620785 [DatabaseIdentifier:11713877] ENSEMBL:ENST00000513753 [DatabaseIdentifier:11713878] ENSEMBL:ENST00000542609 [DatabaseIdentifier:11713880] ENSEMBL:ENST00000619676 [DatabaseIdentifier:11780582] Guide to Pharmacology - Targets:1721 [DatabaseIdentifier:11783572] GeneCards:PRLR [DatabaseIdentifier:11799122] GlyGen:P16471 [DatabaseIdentifier:11836679] HPA:ENSG00000113494-PRLR [DatabaseIdentifier:12121157] OpenTargets:ENSG00000113494 [DatabaseIdentifier:12136073] Orphanet:PRLR [DatabaseIdentifier:12152516] PDB:3N06 [DatabaseIdentifier:12152512] PDB:4I18
databaseName	UniProt
dbId	62176
description	recommendedName: Prolactin receptor shortName: PRL-R
displayName	UniProt:P16471 PRLR
geneName	PRLR
identifier	P16471
isSequenceChanged	false
keyword	3D-structure Alternative splicing Disease variant Disulfide bond Glycoprotein Membrane Metal-binding Proteomics identification Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix Zinc
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PRLR
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1369104] p-Y611-PRLR [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-976964] PRLR [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2002376] p-Y611-PRLR [endosome lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000113494] ENSEMBL:ENSG00000113494 PRLR [ReferenceDNASequence:12745992] UCSC:P16471 PRLR [ReferenceDNASequence:11352116] BioGPS Gene:5618 PRLR [ReferenceDNASequence:11400871] COSMIC - genes:PRLR PRLR [ReferenceDNASequence:11407264] CTD Gene:5618 PRLR [ReferenceDNASequence:11438106] dbSNP Gene:5618 PRLR [ReferenceDNASequence:11815189] HGNC:9446 PRLR [ReferenceDNASequence:11891839] KEGG:hsa:5618 PRLR [ReferenceDNASequence:11981905] Monarch:5618 PRLR [ReferenceDNASequence:12065998] NCBI Gene:5618 PRLR [ReferenceDNASequence:12106890] OMIM:176761 PRLR
referenceTranscript	[ReferenceRNASequence:12582704] RefSeq:NM_001204314.2 PRLR [ReferenceRNASequence:12582709] RefSeq:XM_006714484.3 PRLR [ReferenceRNASequence:12582710] RefSeq:XM_054352940.1 PRLR [ReferenceRNASequence:12582706] RefSeq:NM_001204316.1 PRLR [ReferenceRNASequence:12582713] RefSeq:XM_047417390.1 PRLR [ReferenceRNASequence:12582702] RefSeq:XM_047417388.1 PRLR [ReferenceRNASequence:12582708] RefSeq:NM_001204318.1 PRLR [ReferenceRNASequence:12582712] RefSeq:XM_054352939.1 PRLR [ReferenceRNASequence:12582701] RefSeq:XM_011514068.3 PRLR [ReferenceRNASequence:12582703] RefSeq:NM_000949.7 PRLR [ReferenceRNASequence:12582705] RefSeq:NM_001204315.1 PRLR [ReferenceRNASequence:12582707] RefSeq:NM_001204317.1 PRLR [ReferenceRNASequence:12582711] RefSeq:XM_054352938.1 PRLR
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PRLR_HUMAN B2R882 D1MDP1 Q16354 Q8TD75 Q8TD78 Q96P35 Q96P36 Q9BX87 Q9UHJ5
sequenceLength	622
species	[Species:48887] Homo sapiens
stId	uniprot:P16471
url	http://purl.uniprot.org/uniprot/P16471

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-1369104] p-Y611-PRLR [plasma membrane] [EntityWithAccessionedSequence:R-HSA-976964] PRLR [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2002376] p-Y611-PRLR [endosome lumen]
(referenceSequence)	[ModifiedResidue:1369087] O4'-phospho-L-tyrosine at 611
(interactor)	[UndirectedInteraction:11184041] UniProt:Q8IY26 <-> UniProt:P16471 (IntAct) [UndirectedInteraction:11219961] UniProt:P16471 <-> UniProt:Q9Y5U4 (IntAct)

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