UniProt:P16045 Lgals1

chain
  • initiator methionine:1
  • chain:2-135
checksum FD6967C1F4117122
comment
  • FUNCTION Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69.SUBUNIT Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with CD69.SUBCELLULAR LOCATION Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.CAUTION Was originally thought to originate from human.
crossReference
databaseName UniProt
dbId 94358
description
  • recommendedName: Galectin-1 shortName: Gal-1 alternativeName: 14 kDa lectin alternativeName: Beta-galactoside-binding lectin L-14-I alternativeName: Galaptin alternativeName: Lactose-binding lectin 1 alternativeName: Lectin galactoside-binding soluble 1 alternativeName: S-Lac lectin 1
displayName UniProt:P16045 Lgals1
geneName
  • Lgals1
  • Gbp
identifier P16045
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Apoptosis
  • Cytoplasm
  • Extracellular matrix
  • Lectin
  • Phosphoprotein
  • Reference proteome
  • Secreted
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • Lgals1
otherIdentifier
  • 10425161
  • 1419573_a_at
  • 1455439_a_at
  • 164180_s_at
  • 16852
  • 17312829
  • 4756197
  • 4820230
  • 4937321
  • 4954990
  • 5059643
  • 5091326
  • 5158510
  • 5244118
  • 5349397
  • 5403016
  • 5526349
  • 5559083
  • 99669_at
  • A_51_P465281
  • GE42531
  • GO:0002317
  • GO:0002376
  • GO:0005515
  • GO:0005534
  • GO:0005576
  • GO:0005615
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0006915
  • GO:0007157
  • GO:0007165
  • GO:0030154
  • GO:0030246
  • GO:0030312
  • GO:0030395
  • GO:0031012
  • GO:0031295
  • GO:0043065
  • GO:0043236
  • GO:0045445
  • GO:0046598
  • GO:0048018
  • GO:0050729
  • GO:0098609
  • GO:0098772
  • GO:1990724
  • GO:2000329
  • ILMN_1246613
  • ILMN_2619107
  • Msa.683.0_f_at
  • mMC003871
  • x66532_f_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LEG1_MOUSE
  • P05163
  • P11946
  • P17601
  • Q4FZH4
  • Q99M27
  • Q9D0X0
sequenceLength 135
species [Species:48892] Mus musculus
stId uniprot:P16045
url http://purl.uniprot.org/uniprot/P16045
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