Reactome | UniProt:P15336 ATF2

Schema > ReferenceGeneProduct > Entries

UniProt:P15336 ATF2 Show undefined attributes

chain	chain:1-505
checksum	0190EEFAEC8891A7
comment	FUNCTION Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.SUBUNIT Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Heterodimerization is essential for its transcriptional activity. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity. Interacts with the HK1/VDAC1 complex. Interacts with NBN, MRE11, XPO1, KAT5 and CUL3.INTERACTION Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).ALTERNATIVE PRODUCTS Ubiquitously expressed, with more abundant expression in the brain.DOMAIN The nuclear export signal 1 (N-NES) negatively regulates its nuclear localization and transcriptional activity.PTM Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity (PubMed:12110590, PubMed:9430721). Phosphorylated by PLK3 following hyperosmotic stress (PubMed:21098032). Also phosphorylated and activated by JNK and CaMK4 (PubMed:8855261). ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response (PubMed:15916964). Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity (PubMed:15105425). Phosphorylation at Thr-69 or Thr-71 enhances acetylation of histones H2B and H4 (PubMed:10821277).SIMILARITY Belongs to the bZIP family. ATF subfamily.CAUTION Appears to have histone acetyltransferase (HAT) activity, specifically towards histones H2B and H4 in vitro (PubMed:10821277). However, it is not clear if this activity is genuine or caused by contamination with other histone acetyltransferases in the assay.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
crossReference	[DatabaseIdentifier:11505383] ENSEMBL:ENSG00000115966 [DatabaseIdentifier:12440211] RefSeq:NP_001243020.1 [DatabaseIdentifier:12440207] RefSeq:NP_001243023.1 [DatabaseIdentifier:12440212] RefSeq:NP_001243019.1 [DatabaseIdentifier:12440209] RefSeq:NP_001243022.1 [DatabaseIdentifier:12440210] RefSeq:NP_001243021.1 [DatabaseIdentifier:12440208] RefSeq:NP_001871.2 [DatabaseIdentifier:12280288] Pharos - Targets:P15336 [DatabaseIdentifier:12258490] PRO:P15336 [DatabaseIdentifier:12145698] PDB:4H36 [DatabaseIdentifier:12145694] PDB:1T2K [DatabaseIdentifier:12145693] PDB:1BHI [DatabaseIdentifier:12145695] PDB:8YPE [DatabaseIdentifier:12145696] PDB:8YPF [DatabaseIdentifier:12145699] PDB:6ZQS [DatabaseIdentifier:12145697] PDB:6ZR5 [DatabaseIdentifier:12119948] OpenTargets:ENSG00000115966 [DatabaseIdentifier:11835491] HPA:ENSG00000115966-ATF2 [DatabaseIdentifier:11829838] HMDB Protein:HMDBP08112 [DatabaseIdentifier:11798042] GlyGen:P15336 [DatabaseIdentifier:11782373] GeneCards:ATF2 [DatabaseIdentifier:11740694] ENSEMBL:ENST00000392544 [DatabaseIdentifier:11740695] ENSEMBL:ENST00000345739 [DatabaseIdentifier:11740697] ENSEMBL:ENST00000409635 [DatabaseIdentifier:11740696] ENSEMBL:ENST00000426833 [DatabaseIdentifier:11740700] ENSEMBL:ENST00000409499 [DatabaseIdentifier:11740699] ENSEMBL:ENST00000264110 [DatabaseIdentifier:11740698] ENSEMBL:ENST00000409833 [DatabaseIdentifier:11617999] ENSEMBL:ENSP00000386526 [DatabaseIdentifier:11618000] ENSEMBL:ENSP00000376327 [DatabaseIdentifier:11617997] ENSEMBL:ENSP00000407911 [DatabaseIdentifier:11617998] ENSEMBL:ENSP00000387093 [DatabaseIdentifier:11617996] ENSEMBL:ENSP00000264110 [DatabaseIdentifier:11618001] ENSEMBL:ENSP00000386282 [DatabaseIdentifier:11617995] ENSEMBL:ENSP00000340576
databaseName	UniProt
dbId	50467
description	recommendedName: Cyclic AMP-dependent transcription factor ATF-2 shortName: cAMP-dependent transcription factor ATF-2 alternativeName: Activating transcription factor 2 alternativeName: Cyclic AMP-responsive element-binding protein 2 shortName: CREB-2 shortName: cAMP-responsive element-binding protein 2 alternativeName: HB16 alternativeName: cAMP response element-binding protein CRE-BP1
displayName	UniProt:P15336 ATF2
geneName	ATF2 CREB2 CREBP1
identifier	P15336
isSequenceChanged	false
keyword	3D-structure Acetylation Activator Alternative splicing Cytoplasm DNA damage DNA-binding Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Zinc Zinc-finger
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	ATF2
otherIdentifier	11739868_a_at 11750233_a_at 11750480_a_at 11761942_at 11763586_s_at 1386 1555146_PM_at 1555146_at 16905322 16905353 17119246 1994_at 205446_PM_s_at 205446_s_at 212984_PM_at 212984_at 2588067 2588068 2588069 2588070 2588071 2588072 2588073 2588074 2588075 2588079 2588080 2588081 2588082 2588086 2588090 2588091 2588092 2588093 2588094 2588095 2588096 2588098 2588099 2588100 2588103 2588104 2588106 2588107 2588111 2588112 2588113 2588114 2588115 2588116 37575_at 38902_r_at 8056909 86797_at A_23_P209879 A_24_P128145 A_24_P246467 GE56268 GE81083 GO:0000122 GO:0000165 GO:0000785 GO:0000977 GO:0000978 GO:0000981 GO:0000987 GO:0001228 GO:0001659 GO:0001701 GO:0001865 GO:0001889 GO:0002244 GO:0002376 GO:0003151 GO:0003360 GO:0003418 GO:0003419 GO:0003677 GO:0003682 GO:0003700 GO:0003824 GO:0004402 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005741 GO:0006325 GO:0006351 GO:0006355 GO:0006357 GO:0006606 GO:0006629 GO:0006886 GO:0006913 GO:0006915 GO:0006970 GO:0006974 GO:0007005 GO:0007010 GO:0007033 GO:0007254 GO:0007507 GO:0008140 GO:0008270 GO:0010467 GO:0010485 GO:0010628 GO:0016020 GO:0016071 GO:0016525 GO:0016740 GO:0018107 GO:0019901 GO:0021742 GO:0021743 GO:0021754 GO:0030154 GO:0030509 GO:0031573 GO:0032915 GO:0034599 GO:0035497 GO:0035861 GO:0038066 GO:0042789 GO:0042802 GO:0042803 GO:0043522 GO:0043565 GO:0044013 GO:0045815 GO:0045944 GO:0046872 GO:0046982 GO:0048856 GO:0050872 GO:0051091 GO:0060052 GO:0060245 GO:0060612 GO:0061629 GO:0070342 GO:0072740 GO:0090575 GO:0097009 GO:0097049 GO:0097284 GO:0098586 GO:0110024 GO:0140096 GO:1902110 GO:1902562 GO:1902742 GO:1990144 GO:1990253 GO:1990837 GO:1990841 HMNXSV003011078 HMNXSV003049237 HMNXSV003055076 Hs.80285.0.S1_3p_at Hs2.198166.2.S1_3p_at Hs2.198166.2.S1_3p_x_at ILMN_1748271 PH_hs_0022193 TC02002545.hg TC02002546.hg TC02004705.hg X15875_at g4503032_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-450243] p-T69,T71-ATF2 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-450336] ATF2 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000115966] ENSEMBL:ENSG00000115966 ATF2 [ReferenceDNASequence:12760011] UCSC:P15336 ATF2 [ReferenceDNASequence:12105804] OMIM:123811 ATF2 [ReferenceDNASequence:12084744] NCBI Gene:1386 ATF2 [ReferenceDNASequence:12000651] Monarch:1386 ATF2 [ReferenceDNASequence:11908951] KEGG:hsa:1386 ATF2 [ReferenceDNASequence:11813979] HGNC:784 ATF2 [ReferenceDNASequence:11440015] dbSNP Gene:1386 ATF2 [ReferenceDNASequence:11405723] CTD Gene:1386 ATF2 [ReferenceDNASequence:11402528] COSMIC - genes:ATF2 ATF2 [ReferenceDNASequence:11370862] BioGPS Gene:1386 ATF2
referenceTranscript	[ReferenceRNASequence:12621714] RefSeq:NM_001256091.2 ATF2 [ReferenceRNASequence:12621715] RefSeq:NM_001256092.2 ATF2 [ReferenceRNASequence:12621719] RefSeq:NM_001256094.2 ATF2 [ReferenceRNASequence:12621716] RefSeq:NM_001256093.1 ATF2 [ReferenceRNASequence:12621718] RefSeq:NM_001880.3 ATF2 [ReferenceRNASequence:12621717] RefSeq:NM_001256090.2 ATF2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ATF2_HUMAN A1L3Z2 A4D7U4 A4D7U5 A4D7V1 D3DPE9 G8JLM5 Q13000 Q3B7B7 Q4ZFU9 Q53RY2 Q8TAR1 Q96JT8
sequenceLength	505
species	[Species:48887] Homo sapiens
stId	uniprot:P15336
url	http://purl.uniprot.org/uniprot/P15336

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-450243] p-T69,T71-ATF2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450336] ATF2 [nucleoplasm]
(referenceSequence)	[ModifiedResidue:168386] O-phospho-L-threonine at 71 [ModifiedResidue:450347] O-phospho-L-threonine at 69
(interactor)	[UndirectedInteraction:11272293] UniProt:P15336 <-> UniProt:Q04724 (IntAct) [UndirectedInteraction:11272291] UniProt:P15336 <-> UniProt:Q15532 (IntAct) [UndirectedInteraction:11272289] UniProt:P15336 <-> UniProt:Q8IUH5 (IntAct) [UndirectedInteraction:11272287] UniProt:P15336 <-> UniProt:Q9NQC3 (IntAct) [UndirectedInteraction:11272285] UniProt:P15336 <-> UniProt:P49368 (IntAct) [UndirectedInteraction:11272283] UniProt:P15336 <-> UniProt:P50991 (IntAct) [UndirectedInteraction:11272281] UniProt:P15336 <-> UniProt:Q8NBJ5 (IntAct) [UndirectedInteraction:11272279] UniProt:P15336 <-> UniProt:P30044 (IntAct) [UndirectedInteraction:11272277] UniProt:P15336 <-> UniProt:P63104 (IntAct) [UndirectedInteraction:11272275] UniProt:P15336 <-> UniProt:P30048 (IntAct) [UndirectedInteraction:11272273] UniProt:P15336 <-> UniProt:Q02930 (IntAct) [UndirectedInteraction:11272271] UniProt:P15336 <-> UniProt:O76038 (IntAct) [UndirectedInteraction:11272269] UniProt:P15336 <-> UniProt:P23284 (IntAct) [UndirectedInteraction:11272267] UniProt:P15336 <-> UniProt:P48643 (IntAct) [UndirectedInteraction:11272265] UniProt:P15336 <-> UniProt:O94925 (IntAct) [UndirectedInteraction:11272263] UniProt:P15336 <-> UniProt:P40926 (IntAct) [UndirectedInteraction:11272261] UniProt:P15336 <-> UniProt:P67936 (IntAct) [UndirectedInteraction:11272259] UniProt:P15336 <-> UniProt:P60660 (IntAct) [UndirectedInteraction:11272257] UniProt:P15336 <-> UniProt:P09211 (IntAct) [UndirectedInteraction:11272255] UniProt:P15336 <-> UniProt:P13639 (IntAct) [UndirectedInteraction:11272253] UniProt:P15336 <-> UniProt:P37802 (IntAct) [UndirectedInteraction:11272251] UniProt:P15336 <-> UniProt:Q8NBS9 (IntAct) [UndirectedInteraction:11272249] UniProt:P15336 <-> UniProt:Q66LE6 (IntAct) [UndirectedInteraction:11272247] UniProt:P15336 <-> UniProt:P10809 (IntAct) [UndirectedInteraction:11272245] UniProt:P15336 <-> UniProt:P31949 (IntAct) [UndirectedInteraction:11272243] UniProt:P15336 <-> UniProt:P08758 (IntAct) [UndirectedInteraction:11272241] UniProt:P15336 <-> UniProt:P35232 (IntAct) [UndirectedInteraction:11272239] UniProt:P15336 <-> UniProt:P08134 (IntAct) [UndirectedInteraction:11272237] UniProt:P15336 <-> UniProt:Q99623 (IntAct) [UndirectedInteraction:11272235] UniProt:P15336 <-> UniProt:P05023 (IntAct) [UndirectedInteraction:11272233] UniProt:P15336 <-> UniProt:P30101 (IntAct) [UndirectedInteraction:11272231] UniProt:P15336 <-> UniProt:P63241 (IntAct) [UndirectedInteraction:11272229] UniProt:P15336 <-> UniProt:Q9NS91 (IntAct) [UndirectedInteraction:11272227] UniProt:P15336 <-> UniProt:P80723 (IntAct) [UndirectedInteraction:11272225] UniProt:P15336 <-> UniProt:Q14697 (IntAct) [UndirectedInteraction:11272223] UniProt:P15336 <-> UniProt:P55198 (IntAct) [UndirectedInteraction:11272221] UniProt:P15336 <-> UniProt:Q9Y4X5 (IntAct) [UndirectedInteraction:11272219] UniProt:P15336 <-> UniProt:A4PIW0 (IntAct) [UndirectedInteraction:11272217] UniProt:P15336 <-> UniProt:Q8WYK2 (IntAct) [UndirectedInteraction:11272215] UniProt:P15336 <-> UniProt:Q68G74 (IntAct) [UndirectedInteraction:11272213] UniProt:P15336 <-> UniProt:Q6FG41 (IntAct) [UndirectedInteraction:11272211] UniProt:P15336 <-> UniProt:P78317 (IntAct) [UndirectedInteraction:11272209] UniProt:P15336 <-> UniProt:Q96B26 (IntAct) [UndirectedInteraction:11272207] UniProt:P15336 <-> UniProt:Q9BVG8 (IntAct) [UndirectedInteraction:11272205] UniProt:P15336 <-> UniProt:Q8N9N5-2 (IntAct) [UndirectedInteraction:11156581] UniProt:P23528 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11165251] UniProt:P19367 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11165965] UniProt:O75928-2 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11168427] UniProt:P01100 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11171143] UniProt:P14618 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11177389] UniProt:P07737 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11183739] UniProt:P63165 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11184701] UniProt:P07237 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11188259] UniProt:P12814 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11195055] UniProt:P17275 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11200923] UniProt:P27797 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11204007] UniProt:P14625 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11206545] UniProt:P31943 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11209479] UniProt:P04083 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11213795] UniProt:P16070 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11218071] UniProt:P29966 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11234727] UniProt:P00558 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11237153] UniProt:P21796 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11244239] UniProt:P61981 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11246571] UniProt:O95644 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11250081] UniProt:P35638 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11250785] UniProt:P35613 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11254779] UniProt:P05412 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11258227] UniProt:P06733 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11263795] UniProt:P00338 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11272173] UniProt:P15336 <-> UniProt:P15408 (IntAct) [UndirectedInteraction:11272175] UniProt:P15336 <-> UniProt:P45984 (IntAct) [UndirectedInteraction:11272177] UniProt:P15336 <-> UniProt:O14867 (IntAct) [UndirectedInteraction:11272179] UniProt:P15336 <-> UniProt:Q9NR55 (IntAct) [UndirectedInteraction:11272181] UniProt:P15336 <-> UniProt:P17535 (IntAct) [UndirectedInteraction:11272183] UniProt:P15336 <-> UniProt:P53567 (IntAct) [UndirectedInteraction:11272185] UniProt:P15336 <-> UniProt:P18847 (IntAct) [UndirectedInteraction:11272187] UniProt:P15336 <-> UniProt:P15407 (IntAct) [UndirectedInteraction:11272189] UniProt:P15336 <-> UniProt:P17544 (IntAct) [UndirectedInteraction:11272191] UniProt:P15336 <-> UniProt:P53539 (IntAct) [UndirectedInteraction:11272193] UniProt:P15336 <-> UniProt:Q7L2Z9 (IntAct) [UndirectedInteraction:11272195] UniProt:P15336 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11272195] UniProt:P15336 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11272197] UniProt:P15336 <-> UniProt:Q99986 (IntAct) [UndirectedInteraction:11272199] UniProt:P15336 <-> UniProt:P0C746 (IntAct) [UndirectedInteraction:11272201] UniProt:P15336 <-> UniProt:Q6IQ16 (IntAct) [UndirectedInteraction:11272203] UniProt:P15336 <-> UniProt:Q9BVG8-5 (IntAct)

Cite Us!