UniProt:P14410 SI

chain
  • initiator methionine:1
  • chain:2-1827
  • chain:2-1007
  • chain:1008-1827
checksum DCB93F068AEEF83E
comment
  • FUNCTION Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.CATALYTIC ACTIVITY Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action.CATALYTIC ACTIVITY Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose.SUBUNIT The resulting sucrase and isomaltase subunits stay associated with one another in a complex by non-covalent linkages.INTERACTION Brush border.TISSUE SPECIFICITY Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.PTM The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.PTM Sulfated.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There is a high degree of homology between the isomaltase and sucrase portions (41% of amino acid identity) indicating that this protein is evolved by partial gene duplication.SIMILARITY Belongs to the glycosyl hydrolase 31 family.
crossReference
databaseName UniProt
dbId 65288
description
  • recommendedName: Sucrase-isomaltase, intestinal component recommendedName: Sucrase ecNumber: 3.2.1.48 /component component recommendedName: Isomaltase ecNumber: 3.2.1.10 /component
displayName UniProt:P14410 SI
geneName
  • SI
identifier P14410
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Glycosidase
  • Hydrolase
  • Membrane
  • Multifunctional enzyme
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Signal-anchor
  • Sulfation
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • SI
otherIdentifier
  • 11731688_at
  • 11757393_a_at
  • 16961106
  • 206664_PM_at
  • 206664_at
  • 2703752
  • 2703753
  • 2703754
  • 2703755
  • 2703756
  • 2703757
  • 2703758
  • 2703759
  • 2703760
  • 2703762
  • 2703763
  • 2703764
  • 2703765
  • 2703766
  • 2703767
  • 2703768
  • 2703769
  • 2703770
  • 2703772
  • 2703773
  • 2703774
  • 2703775
  • 2703776
  • 2703777
  • 2703778
  • 2703779
  • 2703780
  • 2703781
  • 2703783
  • 2703784
  • 2703785
  • 2703786
  • 2703787
  • 2703788
  • 2703789
  • 2703791
  • 2703792
  • 2703793
  • 2703795
  • 2703796
  • 2703797
  • 2703799
  • 2703800
  • 2703801
  • 2703802
  • 2703803
  • 2703804
  • 2703805
  • 2703806
  • 2703807
  • 2703808
  • 2703809
  • 2703810
  • 2703811
  • 2703813
  • 2703814
  • 2703815
  • 33491_at
  • 6476
  • 8091811
  • A_32_P302205
  • GE59894
  • GO:0003824
  • GO:0004553
  • GO:0004558
  • GO:0004574
  • GO:0004575
  • GO:0005515
  • GO:0005794
  • GO:0005886
  • GO:0005903
  • GO:0005975
  • GO:0005987
  • GO:0016020
  • GO:0016324
  • GO:0016787
  • GO:0016798
  • GO:0030246
  • GO:0044245
  • GO:0046352
  • GO:0070062
  • GO:0090599
  • HMNXSV003052414
  • ILMN_1739144
  • ILMN_2045849
  • PH_hs_0019889
  • TC03001966.hg
  • X63597_at
  • g4506944_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SUIS_HUMAN
  • A2RUC3
  • Q1JQ80
  • Q1RMC2
sequenceLength 1827
species [Species:48887] Homo sapiens
stId uniprot:P14410
url http://purl.uniprot.org/uniprot/P14410
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