UniProt:P14373 TRIM27

chain
  • chain:1-513
checksum 6F963D9048D8A731
comment
  • FUNCTION E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, PubMed:29688809, PubMed:36111389). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (PubMed:26358190, PubMed:29688809). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (PubMed:22829933). Alternatively, facilitates mitophagy via stabilization of active TBK1 (PubMed:36111389). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (PubMed:35670107). During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (PubMed:35670107).FUNCTION (Microbial infection) Positively regulates hepatitis C virus replication by suppressing type I IFN response during infection.CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Homomultimerizes. Part of a complex consisting of TRIM27, USP7 and MAGEL2; directly interacts with USP7 (PubMed:26365382, PubMed:29688809). Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2. Interacts with PTPN11 (PubMed:26358190). Interacts with autophagy receptor p62/SQSTM1 (PubMed:36111389).SUBUNIT (Microbial infection) Interacts with M.tuberculosis PtpA, whick blocks TRIM27-promoted JNK/p38 MAPK pathway activation and cell apoptosis.SUBUNIT (Microbial infection) Interacts with herpes simplex virus protein ICP0.INTERACTION Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). Co-localizes with p62/SQSTM1 and TBK1 in cytoplasmic structures that are closely associated with the mitochondria (PubMed:36111389).ALTERNATIVE PRODUCTS Expressed in testis namely within the seminiferous tubules.INDUCTION By type I interferons and upon hepatitis C viral infection.DOMAIN The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.DISEASE A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes.SIMILARITY Belongs to the TRIM/RBCC family.
crossReference
databaseName UniProt
dbId 62978
description
  • recommendedName: Zinc finger protein RFP ecNumber evidence="17 19 21 27"2.3.2.27 alternativeName: RING finger protein 76 alternativeName: fullName evidence="32"Ret finger protein alternativeName: Tripartite motif-containing protein 27
displayName UniProt:P14373 TRIM27
geneName
  • TRIM27
  • RFP
  • RNF76
identifier P14373
isSequenceChanged false
keyword
  • Alternative splicing
  • Chromosomal rearrangement
  • Coiled coil
  • Cytoplasm
  • DNA-binding
  • Endosome
  • Metal-binding
  • Mitochondrion
  • Nucleus
  • Proteomics identification
  • Proto-oncogene
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Transferase
  • Transport
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • TRIM27
otherIdentifier
  • 11717335_at
  • 11748222_a_at
  • 11757433_a_at
  • 17016624
  • 17026472
  • 17028529
  • 17033780
  • 17036079
  • 17036088
  • 17038817
  • 17041432
  • 1843_at
  • 210541_PM_s_at
  • 210541_s_at
  • 212116_PM_at
  • 212116_at
  • 212118_PM_at
  • 212118_at
  • 2947578
  • 2947579
  • 2947580
  • 2947581
  • 2947582
  • 2947583
  • 2947584
  • 2947585
  • 2947586
  • 2947587
  • 2947588
  • 2947589
  • 2947590
  • 2947591
  • 2947592
  • 2947593
  • 2947595
  • 2947596
  • 2947597
  • 2947599
  • 2947600
  • 2947601
  • 2947602
  • 2947603
  • 2947606
  • 2947608
  • 40176_at
  • 5987
  • 8124610
  • 8179575
  • A_24_P163405
  • A_32_P137035
  • GE83202
  • GO:0000122
  • GO:0001650
  • GO:0002376
  • GO:0003676
  • GO:0003677
  • GO:0003713
  • GO:0003824
  • GO:0004842
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005730
  • GO:0005737
  • GO:0005739
  • GO:0005768
  • GO:0005769
  • GO:0005829
  • GO:0006325
  • GO:0006355
  • GO:0007283
  • GO:0008270
  • GO:0010507
  • GO:0010508
  • GO:0016192
  • GO:0016567
  • GO:0016605
  • GO:0016740
  • GO:0016925
  • GO:0019789
  • GO:0022414
  • GO:0030904
  • GO:0031965
  • GO:0032480
  • GO:0032481
  • GO:0032897
  • GO:0034314
  • GO:0042147
  • GO:0042802
  • GO:0044790
  • GO:0045087
  • GO:0045814
  • GO:0045893
  • GO:0046872
  • GO:0051127
  • GO:0061630
  • GO:0070534
  • GO:0098542
  • GO:0140096
  • GO:0141039
  • HMNXSV003024865
  • Hs.142653.1.S2_3p_at
  • ILMN_1655482
  • PH_hs_0025781
  • TC06001474.hg
  • TC6_apd_hap1000053.hg
  • TC6_cox_hap2000115.hg
  • TC6_mann_hap4000093.hg
  • TC6_mcf_hap5000098.hg
  • TC6_qbl_hap6000106.hg
  • TC6_ssto_hap7000097.hg
  • g12275875_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TRI27_HUMAN
  • A2BE15
  • Q5RJA8
  • Q5ST26
  • Q6LA73
  • Q6NXR9
  • Q9BZY6
  • Q9UJL3
sequenceLength 513
species [Species:48887] Homo sapiens
stId uniprot:P14373
url http://purl.uniprot.org/uniprot/P14373

Referrals

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