Reactome | UniProt:P14314 PRKCSH

chain	signal peptide:1-14 chain:15-528
checksum	8DAD9776037E878E
comment	FUNCTION Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).PATHWAY Glycan metabolism; N-glycan metabolism.SUBUNIT Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH) (PubMed:10929008). Binds glycosylated PTPRC (By similarity).INTERACTION The disease is caused by variants affecting the gene represented in this entry.
crossReference	[DatabaseIdentifier:12312293] RefSeq:NP_001366538.1 [DatabaseIdentifier:12312296] RefSeq:NP_002734.2 [DatabaseIdentifier:12312295] RefSeq:NP_001366537.1 [DatabaseIdentifier:12312292] RefSeq:NP_001276031.1 [DatabaseIdentifier:12312294] RefSeq:NP_001001329.1 [DatabaseIdentifier:12282373] Pharos - Targets:P14314 [DatabaseIdentifier:12240132] PRO:P14314 [DatabaseIdentifier:12157995] PDB:8EMR [DatabaseIdentifier:12157994] PDB:8D43 [DatabaseIdentifier:12136634] Orphanet:PRKCSH [DatabaseIdentifier:12122049] OpenTargets:ENSG00000130175 [DatabaseIdentifier:11837554] HPA:ENSG00000130175-PRKCSH [DatabaseIdentifier:11831968] HMDB Protein:HMDBP01163 [DatabaseIdentifier:11799933] GlyGen:P14314 [DatabaseIdentifier:11784457] GeneCards:PRKCSH [DatabaseIdentifier:11655819] ENSEMBL:ENST00000587327 [DatabaseIdentifier:11655820] ENSEMBL:ENST00000589838 [DatabaseIdentifier:11655821] ENSEMBL:ENST00000591462 [DatabaseIdentifier:11533122] ENSEMBL:ENSP00000465489 [DatabaseIdentifier:11533121] ENSEMBL:ENSP00000465461 [DatabaseIdentifier:11533120] ENSEMBL:ENSP00000466012 [DatabaseIdentifier:11445948] ENSEMBL:ENSG00000130175
databaseName	UniProt
dbId	55190
description	recommendedName: Glucosidase 2 subunit beta alternativeName: fullName evidence="18"80K-H protein alternativeName: Glucosidase II subunit beta alternativeName: Protein kinase C substrate 60.1 kDa protein heavy chain shortName: PKCSH
displayName	UniProt:P14314 PRKCSH
geneName	PRKCSH G19P1
identifier	P14314
isSequenceChanged	false
keyword	3D-structure Alternative splicing Calcium Direct protein sequencing Disease variant Disulfide bond Endoplasmic reticulum Glycoprotein Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PRKCSH
otherIdentifier	11744126_a_at 16858468 200707_3p_at 200707_PM_at 200707_at 214080_3p_x_at 214080_PM_x_at 214080_x_at 3821201 3821202 3821203 3821204 3821205 3821206 3821207 3821208 3821209 3821210 3821211 3821212 3821214 3821215 3821216 3821217 3821219 3821220 3821221 3821222 3821223 3821224 3821225 3821226 3821227 3821228 3821229 3821230 3821231 3821232 3821233 3821234 3821235 3821236 3821237 3821238 3821239 3821240 3821241 3821242 3821243 39711_at 5589 8025895 A_14_P104018 A_14_P106430 A_14_P131637 A_14_P132080 A_24_P396197 GE671537 GE81187 GO:0001701 GO:0001889 GO:0003723 GO:0005080 GO:0005509 GO:0005515 GO:0005783 GO:0005788 GO:0006491 GO:0010977 GO:0017177 GO:0035556 GO:0043226 GO:0043231 GO:0044325 GO:0044877 GO:0046872 GO:0048856 GO:0051219 GO:0071941 GO:1901135 HMNXSV003012834 Hs.1432.1.S1_3p_a_at ILMN_1777794 ILMN_2400512 PH_hs_0040672 TC19000199.hg TC19001981.hg U50327_s_at g4506076_3p_a_at g4506076_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-879405] PRKCSH [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956890] p-PRKCSH [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-532666] PRKCSH [endoplasmic reticulum lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12722647] UCSC:P14314 PRKCSH [ReferenceDNASequence:12107701] OMIM:177060 PRKCSH [ReferenceDNASequence:12025485] NCBI Gene:5589 PRKCSH [ReferenceDNASequence:11941392] Monarch:5589 PRKCSH [ReferenceDNASequence:11855258] KEGG:hsa:5589 PRKCSH [ReferenceDNASequence:11816082] HGNC:9411 PRKCSH [ReferenceDNASequence:11434162] dbSNP Gene:5589 PRKCSH [ReferenceDNASequence:11408404] CTD Gene:5589 PRKCSH [ReferenceDNASequence:11397471] COSMIC - genes:PRKCSH PRKCSH [ReferenceDNASequence:11311603] BioGPS Gene:5589 PRKCSH [ReferenceDNASequence:ensembl:ENSG00000130175] ENSEMBL:ENSG00000130175 PRKCSH
referenceTranscript	[ReferenceRNASequence:12494365] RefSeq:NM_001289102.2 PRKCSH [ReferenceRNASequence:12494362] RefSeq:NM_001379609.1 PRKCSH [ReferenceRNASequence:12494361] RefSeq:NM_001001329.3 PRKCSH [ReferenceRNASequence:12494363] RefSeq:NM_001379608.1 PRKCSH [ReferenceRNASequence:12494364] RefSeq:NM_002743.3 PRKCSH
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GLU2B_HUMAN A8K318 Q96BU9 Q96D06 Q9P0W9
sequenceLength	528
species	[Species:48887] Homo sapiens
stId	uniprot:P14314
url	http://purl.uniprot.org/uniprot/P14314

(interactor)	[UndirectedInteraction:11305269] UniProt:P04578 <-> UniProt:P14314 (IntAct) [UndirectedInteraction:11165333] UniProt:O14975 <-> UniProt:P14314 (IntAct) [UndirectedInteraction:11160217] UniProt:O14965 <-> UniProt:P14314 (IntAct) [UndirectedInteraction:11159453] UniProt:Q9H0U3 <-> UniProt:P14314 (IntAct) [UndirectedInteraction:11149125] UniProt:P13569 <-> UniProt:P14314 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-879405] PRKCSH [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8956890] p-PRKCSH [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-532666] PRKCSH [endoplasmic reticulum lumen]
(referenceSequence)	[ModifiedResidue:8956957] phosphorylated residue at unknown position

UniProt:P14314 PRKCSH Show undefined attributes

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