Reactome | UniProt:P14126 RPL3

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UniProt:P14126 RPL3 Show undefined attributes

chain	initiator methionine:1 chain:2-387
checksum	986769A218E9698A
comment	FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:22096102, PubMed:24865971). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:22096102). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:22096102). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uL3 plays a role in coordinating processes of accommodating the aminoacyl-tRNA in the PTC (PubMed:22096102).SUBUNIT Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL3 forms together with ES39L one of the contact sites for the signal recognition particle that targets ribosomes to the endoplasmic reticulum membrane (PubMed:22096102, PubMed:24865971, PubMed:9559554).INTERACTION Methylation at His-243 by HPM1 is required for proper 60S subunit assembly and promotes translational elongation fidelity.DISRUPTION PHENOTYPE A mutant confers resistance to trichodermin, a trichotecene toxin produced by plant-pathogenic fungi.MISCELLANEOUS Present with 450 molecules/cell in log phase SD medium.SIMILARITY Belongs to the universal ribosomal protein uL3 family.
crossReference	[DatabaseIdentifier:12142374] PDB:6WOO [DatabaseIdentifier:12314627] RefSeq:NP_014706.1 [DatabaseIdentifier:12241413] PRO:P14126 [DatabaseIdentifier:12145010] PDB:6N8N [DatabaseIdentifier:12145002] PDB:8BJQ [DatabaseIdentifier:12145007] PDB:6N8L [DatabaseIdentifier:12142423] PDB:5ON6 [DatabaseIdentifier:12145011] PDB:7OH3 [DatabaseIdentifier:12145004] PDB:6N8K [DatabaseIdentifier:12142403] PDB:5DGE [DatabaseIdentifier:12142407] PDB:6T4Q [DatabaseIdentifier:12145005] PDB:6N8J [DatabaseIdentifier:12142424] PDB:5TGM [DatabaseIdentifier:12145012] PDB:5JCS [DatabaseIdentifier:12142420] PDB:8CMJ [DatabaseIdentifier:12142404] PDB:5DGF [DatabaseIdentifier:12151498] PDB:5Z3G [DatabaseIdentifier:12145001] PDB:6M62 [DatabaseIdentifier:12145006] PDB:6N8M [DatabaseIdentifier:12152564] PDB:8PFR [DatabaseIdentifier:12145008] PDB:6N8O [DatabaseIdentifier:12144973] PDB:6FT6 [DatabaseIdentifier:12142303] PDB:4U55 [DatabaseIdentifier:12144985] PDB:8AGW [DatabaseIdentifier:12142347] PDB:3J6X [DatabaseIdentifier:12142336] PDB:4V8Z [DatabaseIdentifier:12142371] PDB:8ZGR [DatabaseIdentifier:12144990] PDB:8AGU [DatabaseIdentifier:12142308] PDB:4U4Z [DatabaseIdentifier:12144997] PDB:6S05 [DatabaseIdentifier:12144995] PDB:6YLX [DatabaseIdentifier:12142368] PDB:6TB3 [DatabaseIdentifier:12144991] PDB:6OIG [DatabaseIdentifier:12144982] PDB:8AGX [DatabaseIdentifier:12142321] PDB:6TNU [DatabaseIdentifier:12144993] PDB:5APO [DatabaseIdentifier:12142300] PDB:6I7O [DatabaseIdentifier:12142422] PDB:4U3U [DatabaseIdentifier:12142372] PDB:8ZH3 [DatabaseIdentifier:12144971] PDB:6QIK [DatabaseIdentifier:12142292] PDB:8CG8 [DatabaseIdentifier:12142338] PDB:8Z70 [DatabaseIdentifier:12144984] PDB:8AGV [DatabaseIdentifier:12144983] PDB:5T62 [DatabaseIdentifier:12142400] PDB:5DGV [DatabaseIdentifier:12139467] PDB:4V91 [DatabaseIdentifier:12142351] PDB:8ZHB [DatabaseIdentifier:12144998] PDB:7UQZ [DatabaseIdentifier:12144987] PDB:6YLY [DatabaseIdentifier:12150860] PDB:7NAD [DatabaseIdentifier:12142426] PDB:7ZUW [DatabaseIdentifier:12142416] PDB:4U4R [DatabaseIdentifier:12144994] PDB:5APN [DatabaseIdentifier:12142322] PDB:9F9S [DatabaseIdentifier:12142418] PDB:5M1J [DatabaseIdentifier:12142342] PDB:7NRC [DatabaseIdentifier:12142419] PDB:4V6I [DatabaseIdentifier:12144996] PDB:7OF1 [DatabaseIdentifier:12142319] PDB:4V88 [DatabaseIdentifier:12144967] PDB:8AAF [DatabaseIdentifier:12144979] PDB:6YLG [DatabaseIdentifier:12144989] PDB:8AGT [DatabaseIdentifier:12144978] PDB:6YLH [DatabaseIdentifier:12140531] PDB:7B7D [DatabaseIdentifier:12142314] PDB:8CGN [DatabaseIdentifier:12142425] PDB:7ZUX [DatabaseIdentifier:12150862] PDB:7NAC [DatabaseIdentifier:12144999] PDB:5T6R [DatabaseIdentifier:12142307] PDB:4U4Y [DatabaseIdentifier:12144976] PDB:7V08 [DatabaseIdentifier:12142305] PDB:4U4U [DatabaseIdentifier:12142339] PDB:8CIV [DatabaseIdentifier:12142417] PDB:4U53 [DatabaseIdentifier:12142313] PDB:5DC3 [DatabaseIdentifier:12144992] PDB:7AZY [DatabaseIdentifier:12142346] PDB:3J78 [DatabaseIdentifier:12144972] PDB:4V8T [DatabaseIdentifier:12140535] PDB:8Z71 [DatabaseIdentifier:12142332] PDB:8K82 [DatabaseIdentifier:12144969] PDB:4V7F [DatabaseIdentifier:12142301] PDB:5NDW [DatabaseIdentifier:12144968] PDB:6RZZ [DatabaseIdentifier:12142320] PDB:5DAT [DatabaseIdentifier:12144974] PDB:3JCT [DatabaseIdentifier:12142327] PDB:5MEI [DatabaseIdentifier:12144981] PDB:7UQB [DatabaseIdentifier:12142389] PDB:8CKU [DatabaseIdentifier:12142306] PDB:4U56 [DatabaseIdentifier:12142343] PDB:7NRD [DatabaseIdentifier:12150882] PDB:7R7A [DatabaseIdentifier:12142345] PDB:6SNT [DatabaseIdentifier:12142299] PDB:5NDV [DatabaseIdentifier:12142325] PDB:6HHQ [DatabaseIdentifier:12142357] PDB:3J77 [DatabaseIdentifier:12150867] PDB:7R72 [DatabaseIdentifier:12142334] PDB:4V8Y [DatabaseIdentifier:12142383] PDB:8P4V [DatabaseIdentifier:12140964] PDB:4V5Z [DatabaseIdentifier:12142415] PDB:7ZW0 [DatabaseIdentifier:12142315] PDB:4U6F [DatabaseIdentifier:12142344] PDB:7MPI [DatabaseIdentifier:12144988] PDB:8BIP [DatabaseIdentifier:12142298] PDB:5MC6 [DatabaseIdentifier:12142341] PDB:7MPJ [DatabaseIdentifier:12142330] PDB:5TBW [DatabaseIdentifier:12150868] PDB:7U0H [DatabaseIdentifier:12144975] PDB:7UOO [DatabaseIdentifier:12142312] PDB:6Q8Y [DatabaseIdentifier:12144970] PDB:8Y0U [DatabaseIdentifier:12144966] PDB:6RI5 [DatabaseIdentifier:12142353] PDB:8ZHC [DatabaseIdentifier:12142394] PDB:5TGA [DatabaseIdentifier:12142356] PDB:8ZGY [DatabaseIdentifier:12142421] PDB:8CEH [DatabaseIdentifier:12142391] PDB:8XU8 [DatabaseIdentifier:12150880] PDB:6C0F [DatabaseIdentifier:12142348] PDB:3J6Y [DatabaseIdentifier:12142290] PDB:4V7R [DatabaseIdentifier:12150865] PDB:7NAF [DatabaseIdentifier:12145000] PDB:8HFR [DatabaseIdentifier:12144986] PDB:8AGZ [DatabaseIdentifier:12144958] PDB:9OFV [DatabaseIdentifier:12142359] PDB:8T3A [DatabaseIdentifier:12152562] PDB:8P8M [DatabaseIdentifier:12150873] PDB:7OHR [DatabaseIdentifier:12150872] PDB:7BT6 [DatabaseIdentifier:12142328] PDB:8UTI [DatabaseIdentifier:12142360] PDB:8EVT [DatabaseIdentifier:12152561] PDB:8P8N [DatabaseIdentifier:12145958] PDB:8V84 [DatabaseIdentifier:12144955] PDB:6QT0 [DatabaseIdentifier:12142384] PDB:6Z6J [DatabaseIdentifier:12144961] PDB:7Z34 [DatabaseIdentifier:12142388] PDB:6GQV [DatabaseIdentifier:12142340] PDB:8T30 [DatabaseIdentifier:12142296] PDB:5JUT [DatabaseIdentifier:12142408] PDB:4U4N [DatabaseIdentifier:12144963] PDB:6R87 [DatabaseIdentifier:12142380] PDB:7ZRS [DatabaseIdentifier:12142366] PDB:8T3E [DatabaseIdentifier:12150863] PDB:8V83 [DatabaseIdentifier:12142395] PDB:5FCJ [DatabaseIdentifier:12142349] PDB:8EWB [DatabaseIdentifier:12142381] PDB:8T2Z [DatabaseIdentifier:12142379] PDB:8EVP [DatabaseIdentifier:12150875] PDB:7OHP [DatabaseIdentifier:12142409] PDB:4U4O [DatabaseIdentifier:12142302] PDB:5JUO [DatabaseIdentifier:12150869] PDB:6EM5 [DatabaseIdentifier:12142323] PDB:6T83 [DatabaseIdentifier:12142335] PDB:7N8B [DatabaseIdentifier:12142414] PDB:4U52 [DatabaseIdentifier:12140532] PDB:8YLD [DatabaseIdentifier:12142367] PDB:8T3F [DatabaseIdentifier:12150870] PDB:7OHX [DatabaseIdentifier:12142410] PDB:4U50 [DatabaseIdentifier:12142401] PDB:8CDL [DatabaseIdentifier:12142397] PDB:4U3M [DatabaseIdentifier:12142393] PDB:8K2D [DatabaseIdentifier:12142385] PDB:8CCS [DatabaseIdentifier:12150864] PDB:6ELZ [DatabaseIdentifier:12150861] PDB:7BTB [DatabaseIdentifier:12144965] PDB:6HD7 [DatabaseIdentifier:12150877] PDB:7OHW [DatabaseIdentifier:12151496] PDB:6EM4 [DatabaseIdentifier:12144953] PDB:5GAK [DatabaseIdentifier:12150879] PDB:7OHU [DatabaseIdentifier:12150876] PDB:7OHV [DatabaseIdentifier:12142324] PDB:8EUB [DatabaseIdentifier:12142413] PDB:4U4Q [DatabaseIdentifier:12142412] PDB:5NDG [DatabaseIdentifier:12142304] PDB:5LYB [DatabaseIdentifier:12142350] PDB:8EWC [DatabaseIdentifier:12152563] PDB:4V4B [DatabaseIdentifier:12142370] PDB:8T3D [DatabaseIdentifier:12144954] PDB:7UG6 [DatabaseIdentifier:12142316] PDB:8BN3 [DatabaseIdentifier:12144959] PDB:7ZS5 [DatabaseIdentifier:12142295] PDB:5JUU [DatabaseIdentifier:12144952] PDB:8P8U [DatabaseIdentifier:12144956] PDB:9F58 [DatabaseIdentifier:12142369] PDB:8T3C [DatabaseIdentifier:12144960] PDB:6QTZ [DatabaseIdentifier:12150878] PDB:7OHT [DatabaseIdentifier:12144951] PDB:7OHQ [DatabaseIdentifier:12142309] PDB:6SV4 [DatabaseIdentifier:11447194] ENSEMBL:YOR063W [DatabaseIdentifier:11534962] ENSEMBL:YOR063W [DatabaseIdentifier:11657661] ENSEMBL:YOR063W_mRNA [DatabaseIdentifier:12142294] PDB:5JUS [DatabaseIdentifier:12142293] PDB:5JUP [DatabaseIdentifier:12150866] PDB:6EM1 [DatabaseIdentifier:12144957] PDB:5H4P [DatabaseIdentifier:12142361] PDB:8T3B [DatabaseIdentifier:12142402] PDB:5FCI [DatabaseIdentifier:12144962] PDB:6R84 [DatabaseIdentifier:12142365] PDB:8EVR [DatabaseIdentifier:12142382] PDB:6Z6K [DatabaseIdentifier:12142333] PDB:8P9A [DatabaseIdentifier:12142358] PDB:8EVS [DatabaseIdentifier:12142375] PDB:8T2X [DatabaseIdentifier:12145960] PDB:8V87 [DatabaseIdentifier:12142377] PDB:8T2Y [DatabaseIdentifier:12150871] PDB:7OHY [DatabaseIdentifier:12140536] PDB:8YLR [DatabaseIdentifier:12144964] PDB:6R86 [DatabaseIdentifier:12142337] PDB:7ZPQ [DatabaseIdentifier:12150874] PDB:7OHS [DatabaseIdentifier:12142405] PDB:8CF5 [DatabaseIdentifier:12142318] PDB:6S47 [DatabaseIdentifier:12142378] PDB:5OBM [DatabaseIdentifier:12142363] PDB:8EVQ [DatabaseIdentifier:12142386] PDB:8BQX [DatabaseIdentifier:12142297] PDB:8P85 [DatabaseIdentifier:12142392] PDB:6GQB [DatabaseIdentifier:12142352] PDB:8BQD [DatabaseIdentifier:12142398] PDB:8CDR [DatabaseIdentifier:12142329] PDB:6T7I [DatabaseIdentifier:12142354] PDB:6GQ1 [DatabaseIdentifier:12142331] PDB:5I4L [DatabaseIdentifier:12142399] PDB:4U3N [DatabaseIdentifier:12142396] PDB:8PNN [DatabaseIdentifier:12142311] PDB:8UT0 [DatabaseIdentifier:12142411] PDB:4U51 [DatabaseIdentifier:12142326] PDB:6T7T
databaseName	UniProt
dbId	100191
description	recommendedName: fullName evidence="10"Large ribosomal subunit protein uL3 alternativeName: fullName evidence="11"60S ribosomal protein L3 alternativeName: Maintenance of killer protein 8 alternativeName: RP1 alternativeName: Trichodermin resistance protein alternativeName: YL1
displayName	UniProt:P14126 RPL3
geneName	RPL3 MAK8 TCM1 YOR063W YOR29-14
identifier	P14126
isSequenceChanged	false
keyword	3D-structure Cytoplasm Direct protein sequencing Isopeptide bond Methylation Phosphoprotein Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPL3
otherIdentifier	854229 GO:0000027 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005515 GO:0005575 GO:0005737 GO:0005829 GO:0005840 GO:0006364 GO:0006412 GO:0006414 GO:0022625 GO:1990145 GO:1990904
physicalEntity	[EntityWithAccessionedSequence:R-SCE-72450] RPL3 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-72448] RPL3 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-9633189] RPL3 [cytosol] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11312767] BioGPS Gene:854229 RPL3 [ReferenceDNASequence:12723349] UCSC:P14126 RPL3 [ReferenceDNASequence:11856331] KEGG:sce:YOR063W RPL3 [ReferenceDNASequence:11942556] Monarch:854229 RPL3 [ReferenceDNASequence:12026649] NCBI Gene:854229 RPL3
referenceTranscript	[ReferenceRNASequence:12496700] RefSeq:NM_001183482.1 RPL3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RL3_YEAST D6W2C6 Q08459
sequenceLength	387
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P14126
url	http://purl.uniprot.org/uniprot/P14126

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-72450] RPL3 [cytosol] [EntityWithAccessionedSequence:R-SCE-72448] RPL3 [cytosol] [EntityWithAccessionedSequence:R-SCE-9633189] RPL3 [cytosol]
(interactor)	[UndirectedInteraction:11306533] UniProt:Q05468 <-> UniProt:P14126 (IntAct)

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