Reactome | UniProt:P13987 CD59

chain	signal peptide:1-25 chain:26-102 propeptide:103-128
checksum	2F0D29CBE3C28505
comment	FUNCTION Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260).FUNCTION The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes.SUBUNIT Interacts with T-cell surface antigen CD2.INTERACTION Localizes to the cell surface (PubMed:36797260). Soluble form found in a number of tissues (PubMed:8670172).ALTERNATIVE PRODUCTS N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.PTM Glycated (PubMed:10805801). Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes (PubMed:10805801).DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION CD59 mutation db
crossReference	[DatabaseIdentifier:11473083] ENSEMBL:ENSG00000085063 [DatabaseIdentifier:12370030] RefSeq:NP_976075.1 [DatabaseIdentifier:12370034] RefSeq:NP_000602.1 [DatabaseIdentifier:12370029] RefSeq:NP_001120698.1 [DatabaseIdentifier:12370028] RefSeq:NP_976074.1 [DatabaseIdentifier:12370033] RefSeq:NP_001120695.1 [DatabaseIdentifier:12370032] RefSeq:NP_976076.1 [DatabaseIdentifier:12370031] RefSeq:NP_001120697.1 [DatabaseIdentifier:12370027] RefSeq:NP_001120699.1 [DatabaseIdentifier:12286099] Pharos - Targets:P13987 [DatabaseIdentifier:12265709] PRO:P13987 [DatabaseIdentifier:12158480] PDB:8B0F [DatabaseIdentifier:12182599] PDB:2UX2 [DatabaseIdentifier:12182605] PDB:2J8B [DatabaseIdentifier:12158481] PDB:8B0G [DatabaseIdentifier:12158476] PDB:8B0H [DatabaseIdentifier:12182602] PDB:4BIK [DatabaseIdentifier:12182607] PDB:1CDR [DatabaseIdentifier:12182611] PDB:1ERG [DatabaseIdentifier:12182609] PDB:1ERH [DatabaseIdentifier:12182601] PDB:1CDQ [DatabaseIdentifier:12182600] PDB:2UWR [DatabaseIdentifier:12182603] PDB:6ZD0 [DatabaseIdentifier:12182598] PDB:5IMT [DatabaseIdentifier:12182604] PDB:8CN6 [DatabaseIdentifier:12182606] PDB:1CDS [DatabaseIdentifier:12182610] PDB:2OFS [DatabaseIdentifier:12182608] PDB:5IMY [DatabaseIdentifier:12137154] Orphanet:CD59 [DatabaseIdentifier:12125825] OpenTargets:ENSG00000085063 [DatabaseIdentifier:11571051] ENSEMBL:ENSP00000432942 [DatabaseIdentifier:11571048] ENSEMBL:ENSP00000340210 [DatabaseIdentifier:11571046] ENSEMBL:ENSP00000494884 [DatabaseIdentifier:11571052] ENSEMBL:ENSP00000410182 [DatabaseIdentifier:11571053] ENSEMBL:ENSP00000498879 [DatabaseIdentifier:11571049] ENSEMBL:ENSP00000403511 [DatabaseIdentifier:11571050] ENSEMBL:ENSP00000404822 [DatabaseIdentifier:11571047] ENSEMBL:ENSP00000379191 [DatabaseIdentifier:11571045] ENSEMBL:ENSP00000498448 [DatabaseIdentifier:11693745] ENSEMBL:ENST00000415002 [DatabaseIdentifier:11693751] ENSEMBL:ENST00000445143 [DatabaseIdentifier:11693747] ENSEMBL:ENST00000395850 [DatabaseIdentifier:11693752] ENSEMBL:ENST00000351554 [DatabaseIdentifier:11693746] ENSEMBL:ENST00000642928 [DatabaseIdentifier:11693744] ENSEMBL:ENST00000437761 [DatabaseIdentifier:11693750] ENSEMBL:ENST00000651785 [DatabaseIdentifier:11693748] ENSEMBL:ENST00000527577 [DatabaseIdentifier:11693749] ENSEMBL:ENST00000652678 [DatabaseIdentifier:11788209] GeneCards:CD59 [DatabaseIdentifier:11803753] GlyGen:P13987 [DatabaseIdentifier:11841264] HPA:ENSG00000085063-CD59
databaseName	UniProt
dbId	51674
description	recommendedName: CD59 glycoprotein alternativeName: 1F5 antigen alternativeName: 20 kDa homologous restriction factor shortName: HRF-20 shortName: HRF20 alternativeName: MAC-inhibitory protein shortName: MAC-IP alternativeName: MEM43 antigen alternativeName: fullName evidence="18"Membrane attack complex inhibition factor shortName evidence="18"MACIF alternativeName: Membrane inhibitor of reactive lysis shortName: MIRL alternativeName: Protectin cdAntigenName evidence="17"CD59/cdAntigenName
displayName	UniProt:P13987 CD59
geneName	CD59 MIC11 MIN1 MIN2 MIN3 MSK21
identifier	P13987
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Direct protein sequencing Disease variant Disulfide bond Glycation Glycoprotein GPI-anchor Hereditary hemolytic anemia Lipoprotein Membrane Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	CD59
otherIdentifier	11718100_s_at 11718101_at 11718102_at 11757306_s_at 16737194 16737200 200983_PM_x_at 200983_x_at 200984_PM_s_at 200984_s_at 200985_PM_s_at 200985_s_at 212463_PM_at 212463_at 228748_PM_at 228748_at 3368706 3368708 3368709 3368710 3368711 3368712 3368713 3368714 3368715 3368716 3368717 3368718 3368719 3368720 3368721 3368722 3368723 3368724 3368725 3368726 3368727 3368728 3368729 3368730 3368732 3368734 3368735 3368737 3368738 3368739 3368740 3368741 3368742 3368743 3368745 3368746 3368747 39170_at 39351_at 62133_at 7947425 966 A_23_P75523 A_24_P141481 A_24_P639441 A_24_P784765 A_33_P3409746 GE56215 GE79480 GE88415 GO:0000139 GO:0001848 GO:0001971 GO:0002376 GO:0005515 GO:0005576 GO:0005615 GO:0005789 GO:0005886 GO:0005925 GO:0006956 GO:0007166 GO:0007596 GO:0009897 GO:0009986 GO:0012507 GO:0016020 GO:0030133 GO:0030449 GO:0031410 GO:0031982 GO:0033116 GO:0035579 GO:0043226 GO:0045916 GO:0070062 GO:0070821 GO:0098552 GO:0140311 GO:1903659 GO:1903660 HMNXSV003026907 HMNXSV003054760 Hs.119663.0.S1_3p_a_at Hs.119663.0.S2_3p_a_at Hs.293774.0.A1_3p_at Hs.99766.0.S1_3p_at ILMN_1669659 ILMN_1724789 ILMN_2333687 M84349_at PH_hs_0014290 TC11001540.hg TC11003112.hg TC11003113.hg g10835164_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2530458] CD59 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6799513] CD59 [specific granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800885] CD59 [tertiary granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5689804] GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6808775] GPI-CD59 [transport vesicle] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6808772] GPI-CD59 [Golgi membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5689453] GPI-CD59 [endoplasmic reticulum membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5689801] GPI-CD59 [ER to Golgi transport vesicle membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11968034] Monarch:966 CD59 [ReferenceDNASequence:12738654] UCSC:P13987 CD59 [ReferenceDNASequence:12111008] OMIM:107271 CD59 [ReferenceDNASequence:12052127] NCBI Gene:966 CD59 [ReferenceDNASequence:ensembl:ENSG00000085063] ENSEMBL:ENSG00000085063 CD59 [ReferenceDNASequence:11338245] BioGPS Gene:966 CD59 [ReferenceDNASequence:11399498] COSMIC - genes:CD59 CD59 [ReferenceDNASequence:11414347] CTD Gene:966 CD59 [ReferenceDNASequence:11436508] dbSNP Gene:966 CD59 [ReferenceDNASequence:11819858] HGNC:1689 CD59 [ReferenceDNASequence:11879180] KEGG:hsa:966 CD59
referenceTranscript	[ReferenceRNASequence:12551842] RefSeq:NM_000611.6 CD59 [ReferenceRNASequence:12551847] RefSeq:NM_203331.3 CD59 [ReferenceRNASequence:12551846] RefSeq:NM_001127223.1 CD59 [ReferenceRNASequence:12551843] RefSeq:NM_001127225.2 CD59 [ReferenceRNASequence:12551844] RefSeq:NM_001127226.2 CD59 [ReferenceRNASequence:12551845] RefSeq:NM_001127227.2 CD59 [ReferenceRNASequence:12551841] RefSeq:NM_203329.3 CD59 [ReferenceRNASequence:12551840] RefSeq:NM_203330.2 CD59
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CD59_HUMAN E9PR17
sequenceLength	128
species	[Species:48887] Homo sapiens
stId	uniprot:P13987
url	http://purl.uniprot.org/uniprot/P13987

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2530458] CD59 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6799513] CD59 [specific granule membrane] [EntityWithAccessionedSequence:R-HSA-6800885] CD59 [tertiary granule membrane] [EntityWithAccessionedSequence:R-HSA-5689804] GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] [EntityWithAccessionedSequence:R-HSA-6808775] GPI-CD59 [transport vesicle] [EntityWithAccessionedSequence:R-HSA-6808772] GPI-CD59 [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-5689453] GPI-CD59 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-5689801] GPI-CD59 [ER to Golgi transport vesicle membrane]
(referenceSequence)	[GroupModifiedResidue:9768795] L-asparagine amide (GPI-anchor amidated amino acid carboxyl end residue(1?)) at 102
(interactor)	[UndirectedInteraction:11147859] UniProt:P13569 <-> UniProt:P13987 (IntAct) [UndirectedInteraction:11226105] UniProt:P42858 <-> UniProt:P13987 (IntAct) [UndirectedInteraction:11253611] UniProt:P13987 <-> UniProt:O35587 (IntAct) [UndirectedInteraction:11253613] UniProt:P13987 <-> UniProt:Q15363 (IntAct) [UndirectedInteraction:11253615] UniProt:P13987 <-> IntAct:EBI-25865403 (IntAct) [UndirectedInteraction:11253617] UniProt:P13987 <-> UniProt:Q5JX71 (IntAct) [UndirectedInteraction:11253621] UniProt:P13987 <-> UniProt:Q778I9 (IntAct) [UndirectedInteraction:11253623] UniProt:P13987 <-> UniProt:Q86T26 (IntAct) [UndirectedInteraction:11253627] UniProt:P13987 <-> UniProt:Q01415 (IntAct)

UniProt:P13987 CD59 Show undefined attributes

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