UniProt:P13861 PRKAR2A

chain
  • initiator methionine:1
  • chain:2-404
checksum C7D6E8E476E1DB65
comment
  • FUNCTION Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.SUBUNIT The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3. Interacts with the phosphorylated form of PJA2. Interacts with MYRIP. This interaction may link PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). Forms a complex composed of PRKAR2A, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (PubMed:27484798). Interacts with ADCY8; inhibits adenylate cyclase activity through PKA phosphorylation (PubMed:22976297).INTERACTION Colocalizes with PJA2 in the cytoplasm and the cell membrane.ALTERNATIVE PRODUCTS Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.PTM Phosphorylated by the activated catalytic chain.SIMILARITY Belongs to the cAMP-dependent kinase regulatory chain family.
crossReference
databaseName UniProt
dbId 57841
description
  • recommendedName: cAMP-dependent protein kinase type II-alpha regulatory subunit
displayName UniProt:P13861 PRKAR2A
geneName
  • PRKAR2A
  • PKR2
  • PRKAR2
identifier P13861
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • cAMP
  • cAMP-binding
  • Cell membrane
  • Cytoplasm
  • Membrane
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • PRKAR2A
otherIdentifier
  • 116_at
  • 11739647_a_at
  • 11739648_a_at
  • 11746478_a_at
  • 11760103_at
  • 11761290_x_at
  • 16953735
  • 204842_PM_x_at
  • 204842_x_at
  • 204843_PM_s_at
  • 204843_s_at
  • 213052_PM_at
  • 213052_at
  • 225000_PM_at
  • 225000_at
  • 225011_PM_at
  • 225011_at
  • 2673733
  • 2673734
  • 2673735
  • 2673736
  • 2673737
  • 2673738
  • 2673739
  • 2673740
  • 2673741
  • 2673742
  • 2673743
  • 2673744
  • 2673745
  • 2673747
  • 2673749
  • 2673750
  • 2673753
  • 2673759
  • 2673760
  • 2673761
  • 2673762
  • 38905_at
  • 46315_at
  • 5576
  • 65962_at
  • 8087210
  • A_23_P22214
  • A_24_P943335
  • A_32_P142991
  • GE59721
  • GE79300
  • GO:0000166
  • GO:0001932
  • GO:0004862
  • GO:0005515
  • GO:0005737
  • GO:0005813
  • GO:0005815
  • GO:0005829
  • GO:0005886
  • GO:0005925
  • GO:0005930
  • GO:0005952
  • GO:0007189
  • GO:0007339
  • GO:0008603
  • GO:0016020
  • GO:0016301
  • GO:0019904
  • GO:0030552
  • GO:0031588
  • GO:0031625
  • GO:0032991
  • GO:0034236
  • GO:0035556
  • GO:0044853
  • GO:0070062
  • GO:0097546
  • GO:0098772
  • GO:0141162
  • HMNXSV003024942
  • HMNXSV003041145
  • Hs.286241.0.S1_3p_at
  • Hs.286241.0.S2_3p_at
  • Hs.289075.1.S1_3p_at
  • ILMN_1681888
  • PH_hs_0020943
  • TC03001389.hg
  • X14968_at
  • g12803842_3p_a_at
  • g4758957_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KAP2_HUMAN
  • Q16823
  • Q9BUB1
sequenceLength 404
species [Species:48887] Homo sapiens
stId uniprot:P13861
url http://purl.uniprot.org/uniprot/P13861

Referrals

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