UniProt:P13647 KRT5

chain
  • chain:1-590
checksum E9D5318E01F55145
comment
  • FUNCTION Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity).SUBUNIT Heterodimer of a type I and a type II keratin (PubMed:22705788, PubMed:31995743). Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network (PubMed:28899683). Forms a heterodimer (via 2B domains) with KRT14 (via 2B domains) (PubMed:22705788, PubMed:24940650, PubMed:31995743). Interacts with PLEC isoform 1C, when in a heterodimer with KRT14 (PubMed:24940650). Interacts with TCHP (PubMed:15731013). Interacts with EPPK1 (By similarity). Interacts with AMELX (By similarity). Interacts with PKP1 (via N-terminus) and PKP2 (PubMed:10852826).INTERACTION Expressed in corneal epithelium (at protein level) (PubMed:26758872). Expressed in keratinocytes (at protein level) (PubMed:20128788, PubMed:31302245).PTM Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle (By similarity). Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis (By similarity). CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury (By similarity).PTM O-glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).SIMILARITY Belongs to the intermediate filament family.
crossReference
databaseName UniProt
dbId 57747
description
  • recommendedName: Keratin, type II cytoskeletal 5 alternativeName: 58 kDa cytokeratin alternativeName: Cytokeratin-5 shortName: CK-5 alternativeName: Keratin-5 shortName: K5 alternativeName: Type-II keratin Kb5
displayName UniProt:P13647 KRT5
geneName
  • KRT5
identifier P13647
isSequenceChanged false
keyword
  • 3D-structure
  • Coiled coil
  • Cytoplasm
  • Disease variant
  • Epidermolysis bullosa
  • Intermediate filament
  • Keratin
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • KRT5
otherIdentifier
  • 11721258_a_at
  • 11751723_a_at
  • 201820_PM_at
  • 201820_at
  • 3455207
  • 3455208
  • 3455209
  • 3455210
  • 3455211
  • 3455212
  • 3455213
  • 3455214
  • 3455215
  • 3455216
  • 3455217
  • 3455218
  • 3455219
  • 3455220
  • 3455221
  • 3455222
  • 3455223
  • 3455224
  • 3455225
  • 3455226
  • 3455227
  • 3455228
  • 3455229
  • 3455230
  • 3455231
  • 3455232
  • 3455233
  • 3455234
  • 3455235
  • 3455236
  • 3455237
  • 3455410
  • 3455442
  • 3455443
  • 3455461
  • 3455466
  • 3455467
  • 3455499
  • 3455817
  • 3852
  • 613_at
  • 7963427
  • A_23_P218047
  • GE80914
  • GO:0005198
  • GO:0005200
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0005882
  • GO:0007010
  • GO:0008544
  • GO:0009612
  • GO:0016020
  • GO:0030280
  • GO:0030334
  • GO:0031424
  • GO:0032880
  • GO:0045095
  • GO:0045107
  • GO:0045109
  • GO:0048856
  • GO:0070062
  • GO:0097110
  • HMNXSV003012282
  • ILMN_1801632
  • M21389_at
  • PH_hs_0020156
  • TC12001526.hg
  • TC12002888.hg
  • g4557889_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • K2C5_HUMAN
  • Q6PI71
  • Q6UBJ0
  • Q8TA91
sequenceLength 590
species [Species:48887] Homo sapiens
stId uniprot:P13647
url http://purl.uniprot.org/uniprot/P13647
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