UniProt:P13164 IFITM1

chain
  • chain:1-125
checksum 10EE5B64894838ED
comment
  • FUNCTION IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436).SUBUNIT Interacts with CD81 (PubMed:2398277, PubMed:26354436). Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells (PubMed:1383329). Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation (PubMed:19499152).SUBCELLULAR LOCATION Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.INDUCTION By IFN-alpha and IFNG/IFN-gamma.PTM Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity.SIMILARITY Belongs to the CD225/Dispanin family.
crossReference
databaseName UniProt
dbId 57158
description
  • recommendedName: fullName evidence="24"Interferon-induced transmembrane protein 1 alternativeName: Dispanin subfamily A member 2a shortName: DSPA2a alternativeName: Interferon-induced protein 17 alternativeName: Interferon-inducible protein 9-27 alternativeName: Leu-13 antigen cdAntigenNameCD225/cdAntigenName
displayName UniProt:P13164 IFITM1
geneName
  • IFITM1
  • CD225
  • IFI17
identifier P13164
isSequenceChanged false
keyword
  • Antiviral defense
  • Cell membrane
  • Immunity
  • Innate immunity
  • Lipoprotein
  • Lysosome
  • Membrane
  • Osteogenesis
  • Palmitate
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • IFITM1
otherIdentifier
  • 11715670_a_at
  • 11715671_x_at
  • 16720085
  • 201601_PM_x_at
  • 201601_x_at
  • 214022_PM_s_at
  • 214022_s_at
  • 3315666
  • 3315668
  • 3315669
  • 3315670
  • 3315676
  • 3315678
  • 3315679
  • 3315680
  • 3315681
  • 3315682
  • 3315683
  • 3315684
  • 3315685
  • 3315686
  • 3315687
  • 3357846
  • 3357847
  • 3357848
  • 3357851
  • 3357861
  • 675_at
  • 676_g_at
  • 7937335
  • 8519
  • A_14_P115128
  • A_14_P137394
  • A_23_P72737
  • A_33_P3423941
  • GE57504
  • GE85917
  • GO:0001503
  • GO:0002376
  • GO:0005515
  • GO:0005764
  • GO:0005765
  • GO:0005794
  • GO:0005886
  • GO:0007166
  • GO:0008285
  • GO:0009615
  • GO:0016020
  • GO:0030336
  • GO:0032991
  • GO:0034341
  • GO:0035455
  • GO:0035456
  • GO:0045071
  • GO:0045087
  • GO:0045669
  • GO:0046597
  • GO:0051607
  • GO:0060337
  • GO:0098542
  • HMNXSV003001513
  • Hs.146360.1.A1_3p_a_at
  • ILMN_1801246
  • ILMN_1870392
  • J04164_at
  • PH_hs_0026376
  • TC11000011.hg
  • g4504580_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IFM1_HUMAN
  • Q15322
  • Q53XZ0
sequenceLength 125
species [Species:48887] Homo sapiens
stId uniprot:P13164
url http://purl.uniprot.org/uniprot/P13164
Cite Us!