Reactome | UniProt:P12367 Prkar2a

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UniProt:P12367 Prkar2a Show undefined attributes

chain	initiator methionine:1 chain:2-401
checksum	E4191DAC197A9E39
comment	FUNCTION Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.SUBUNIT The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4. Interacts with CBFA2T3 (By similarity). Interacts with the phosphorylated form of PJA2 (By similarity). Interacts with MYRIP. This interaction may link PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). Forms a complex composed of PRKAR2A, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (By similarity). Interacts with ADCY8; inhibits adenylate cyclase activity through PKA phosphorylation (By similarity).INTERACTION Colocalizes with PJA2 in the cytoplasm and the cell membrane.TISSUE SPECIFICITY Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.PTM Phosphorylated by the activated catalytic chain.SIMILARITY Belongs to the cAMP-dependent kinase regulatory chain family.
crossReference	[DatabaseIdentifier:12246330] PRO:P12367 [DatabaseIdentifier:12185919] PDB:3J4R [DatabaseIdentifier:12185918] PDB:1L6E [DatabaseIdentifier:12185916] PDB:2QVS [DatabaseIdentifier:12185917] PDB:3J4Q [DatabaseIdentifier:12185915] PDB:1R2A [DatabaseIdentifier:12163365] PDB:9D2F [DatabaseIdentifier:12185914] PDB:2IZY [DatabaseIdentifier:11936112] MGI:108025
databaseName	UniProt
dbId	93651
description	recommendedName: cAMP-dependent protein kinase type II-alpha regulatory subunit
displayName	UniProt:P12367 Prkar2a
geneName	Prkar2a
identifier	P12367
isSequenceChanged	false
keyword	3D-structure Acetylation cAMP cAMP-binding Cell membrane Cytoplasm Membrane Nucleotide-binding Phosphoprotein Reference proteome Repeat
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	Prkar2a
physicalEntity	[EntityWithAccessionedSequence:R-MMU-9010721] Prkar2a [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5610412] PRKAR2A [ciliary base] - Mus musculus [EntityWithAccessionedSequence:R-MMU-57840] PRKAR2A [cytosol] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12699098] UCSC:P12367 Prkar2a
schemaClass	ReferenceGeneProduct
secondaryIdentifier	KAP2_MOUSE
sequenceLength	401
species	[Species:48892] Mus musculus
stId	uniprot:P12367
url	http://purl.uniprot.org/uniprot/P12367

Referrals

(interactor)	[UndirectedInteraction:11284413] UniProt:D3YVF0 <-> UniProt:P12367 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-9010721] Prkar2a [cytosol] [EntityWithAccessionedSequence:R-MMU-5610412] PRKAR2A [ciliary base] [EntityWithAccessionedSequence:R-MMU-57840] PRKAR2A [cytosol]

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