Reactome | UniProt:P11911 Cd79a

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UniProt:P11911 Cd79a Show undefined attributes

chain	signal peptide:1-28 chain:29-220
checksum	A4C648C2BE6D3E38
comment	FUNCTION Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.SUBUNIT Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-204, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity.SUBCELLULAR LOCATION Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.TISSUE SPECIFICITY B-cells.DOMAIN The transmembrane helices of CD79A and CD79B chains and two IgM heavy chains assembly in a four-helix bundle structure that appears to be conserved among different BCR isotypes.PTM Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.PTM Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation.DISRUPTION PHENOTYPE Mice display impaired B-cell development which does not progress pass the progenitor stage.
crossReference	[DatabaseIdentifier:12470478] RefSeq:NP_031681.2 [DatabaseIdentifier:12271388] PRO:P11911 [DatabaseIdentifier:12166621] PDB:8EMA [DatabaseIdentifier:12166618] PDB:8E4C [DatabaseIdentifier:11931507] MGI:101774 [DatabaseIdentifier:11807624] GlyGen:P11911 [DatabaseIdentifier:11762313] ENSEMBL:ENSMUST00000003469 [DatabaseIdentifier:11639614] ENSEMBL:ENSMUSP00000003469 [DatabaseIdentifier:11520613] ENSEMBL:ENSMUSG00000003379
databaseName	UniProt
dbId	86330
description	recommendedName: B-cell antigen receptor complex-associated protein alpha chain alternativeName: Ig-alpha alternativeName: MB-1 membrane glycoprotein alternativeName: Membrane-bound immunoglobulin-associated protein alternativeName: Surface IgM-associated protein cdAntigenNameCD79a/cdAntigenName
displayName	UniProt:P11911 Cd79a
geneName	Cd79a Iga Mb-1
identifier	P11911
isSequenceChanged	false
keyword	3D-structure Adaptive immunity Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Methylation Phosphoprotein Receptor Reference proteome Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	Cd79a
otherIdentifier	102778_at 10551025 12518 1418830_at 17475127 4566171 4702086 4764203 4888271 4977896 5326333 5332367 5448937 5480857 5559134 5593767 A_52_P651316 A_66_P120987 GE34831 GO:0002250 GO:0002376 GO:0004888 GO:0005515 GO:0005768 GO:0005771 GO:0005886 GO:0007166 GO:0009897 GO:0016020 GO:0019815 GO:0030154 GO:0030183 GO:0042100 GO:0042113 GO:0042802 GO:0045121 GO:0050853 GO:0071755 ILMN_1246266 mMC015345 x13450_s_at
physicalEntity	[EntityWithAccessionedSequence:R-MMU-1112646] p-Y182,193-Cd79a [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-1112648] Cd79a (Ig-alpha) [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-197154] Cd79a [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-983539] phospho-Cd79a [plasma membrane] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12715440] UCSC:P11911 Cd79a [ReferenceDNASequence:12098409] NCBI Gene:12518 Cd79a [ReferenceDNASequence:12014316] Monarch:12518 Cd79a [ReferenceDNASequence:11921139] KEGG:mmu:12518 Cd79a [ReferenceDNASequence:11384527] BioGPS Gene:12518 Cd79a
referenceTranscript	[ReferenceRNASequence:12651950] RefSeq:NM_007655.4 Cd79a
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CD79A_MOUSE Q6GTY0
sequenceLength	220
species	[Species:48892] Mus musculus
stId	uniprot:P11911
url	http://purl.uniprot.org/uniprot/P11911

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-1112646] p-Y182,193-Cd79a [plasma membrane] [EntityWithAccessionedSequence:R-MMU-1112648] Cd79a (Ig-alpha) [plasma membrane] [EntityWithAccessionedSequence:R-MMU-197154] Cd79a [plasma membrane] [EntityWithAccessionedSequence:R-MMU-983539] phospho-Cd79a [plasma membrane]
(referenceSequence)	[ModifiedResidue:1112649] O4'-phospho-L-tyrosine at 182 [ModifiedResidue:1112647] O4'-phospho-L-tyrosine at 193 [ModifiedResidue:10027848] O4'-phospho-L-tyrosine at 188 (in Homo sapiens) [ModifiedResidue:10027849] O4'-phospho-L-tyrosine at 199 (in Homo sapiens)

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