UniProt:P11217 PYGM

chain
  • initiator methionine:1
  • chain:2-842
checksum EBDB7D80D740B68F
comment
  • FUNCTION Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.CATALYTIC ACTIVITY [(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphateCOFACTOR Allosterically regulated through the non-covalent binding of metabolites, being activated by AMP and inhibited by ATP, ADP, and glucose-6-phosphate. The activity is also controlled by post-translational modifications including phosphorylation.SUBUNIT Homodimer (PubMed:1150650, PubMed:16523484). Homotetramer; to form the enzymatically active phosphorylase A (PubMed:1150650).INTERACTION Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the glycogen phosphorylase family.
crossReference
databaseName UniProt
dbId 61666
description
  • recommendedName: fullName evidence="22"Glycogen phosphorylase, muscle form ecNumber evidence="11 16"2.4.1.1 alternativeName: fullName evidence="20"Myophosphorylase
displayName UniProt:P11217 PYGM
geneName
  • PYGM
identifier P11217
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Allosteric enzyme
  • Alternative splicing
  • Carbohydrate metabolism
  • Disease variant
  • Glycogen metabolism
  • Glycogen storage disease
  • Glycosyltransferase
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Pyridoxal phosphate
  • Reference proteome
  • Transferase
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • PYGM
otherIdentifier
  • 11724200_a_at
  • 16739979
  • 205577_PM_at
  • 205577_at
  • 3377015
  • 3377017
  • 3377018
  • 3377019
  • 3377020
  • 3377021
  • 3377022
  • 3377023
  • 3377024
  • 3377025
  • 3377026
  • 3377027
  • 3377028
  • 3377029
  • 3377030
  • 3377031
  • 3377032
  • 3377033
  • 3377034
  • 3377035
  • 3377036
  • 3377038
  • 3377039
  • 3377040
  • 3377041
  • 3377042
  • 40057_at
  • 5837
  • 7949124
  • A_23_P405815
  • A_23_P52657
  • GE60545
  • GO:0000166
  • GO:0003824
  • GO:0004645
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0005975
  • GO:0005977
  • GO:0005980
  • GO:0008184
  • GO:0016740
  • GO:0016757
  • GO:0030170
  • GO:0070062
  • ILMN_1720849
  • M32598_at
  • PH_hs_0009271
  • TC11001910.hg
  • g5032008_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PYGM_HUMAN
  • A0AVK1
  • A6NDY6
sequenceLength 842
species [Species:48887] Homo sapiens
stId uniprot:P11217
url http://purl.uniprot.org/uniprot/P11217
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