Reactome | UniProt:P11169 SLC2A3

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UniProt:P11169 SLC2A3 Show undefined attributes

chain	chain:1-496
checksum	F601CD6892F16516
comment	FUNCTION Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:26176916, PubMed:9477959). Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity).CATALYTIC ACTIVITY D-glucose(out) = D-glucose(in)CATALYTIC ACTIVITY D-galactose(in) = D-galactose(out)ACTIVITY REGULATION Deoxyglucose transport is inhibited by D-glucose, D-galactose and maltose (PubMed:8457197). Galactose transport is inhibited by D-glucose and maltose (PubMed:8457197).BIOPHYSICOCHEMICAL PROPERTIES Interacts with SMIM43; the interaction may promote SLC2A3-mediated glucose transport to meet the energy needs of mesendoderm differentiation.INTERACTION Localized to densely spaced patches along neuronal processes.TISSUE SPECIFICITY Highly expressed in brain (PubMed:8457197). Expressed in many tissues.DOMAIN Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
crossReference	[DatabaseIdentifier:12460433] RefSeq:NP_008862.1 [DatabaseIdentifier:12286771] Pharos - Targets:P11169 [DatabaseIdentifier:12266928] PRO:P11169 [DatabaseIdentifier:12187353] PDB:7SPS [DatabaseIdentifier:12187356] PDB:7SPT [DatabaseIdentifier:12187352] PDB:5C65 [DatabaseIdentifier:12187354] PDB:4ZWB [DatabaseIdentifier:12187355] PDB:4ZWC [DatabaseIdentifier:12187357] PDB:7CRZ [DatabaseIdentifier:12187351] PDB:4ZW9 [DatabaseIdentifier:12137792] Orphanet:SLC2A3 [DatabaseIdentifier:12126517] OpenTargets:ENSG00000059804 [DatabaseIdentifier:11841923] HPA:ENSG00000059804-SLC2A3 [DatabaseIdentifier:11833935] HMDB Protein:HMDBP11764 [DatabaseIdentifier:11804519] GlyGen:P11169 [DatabaseIdentifier:11788897] GeneCards:SLC2A3 [DatabaseIdentifier:11780757] Guide to Pharmacology - Targets:877 [DatabaseIdentifier:11755584] ENSEMBL:ENST00000707174 [DatabaseIdentifier:11755585] ENSEMBL:ENST00000075120 [DatabaseIdentifier:11632885] ENSEMBL:ENSP00000516774 [DatabaseIdentifier:11632886] ENSEMBL:ENSP00000075120 [DatabaseIdentifier:11516071] ENSEMBL:ENSG00000059804
databaseName	UniProt
dbId	56068
description	recommendedName: fullName evidence="11"Solute carrier family 2, facilitated glucose transporter member 3 alternativeName: fullName evidence="10"Glucose transporter type 3, brain shortName evidence="10"GLUT-3
displayName	UniProt:P11169 SLC2A3
geneName	SLC2A3 GLUT3
identifier	P11169
isSequenceChanged	false
keyword	3D-structure Cell membrane Cell projection Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Sugar transport Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType	Protein
name	SLC2A3
otherIdentifier	11734657_s_at 11736555_s_at 11736556_s_at 11747751_s_at 11752739_s_at 16760868 202497_PM_x_at 202497_x_at 202498_PM_s_at 202498_s_at 202499_PM_s_at 202499_s_at 216236_PM_s_at 216236_s_at 222088_PM_s_at 222088_s_at 236571_PM_at 236571_at 2416636 3105894 3105895 3442814 3442817 3442818 3442820 3442823 3442824 3442825 3442831 3442838 3442845 3442847 3442862 3442863 3442864 3442865 3442866 3442867 3442868 3442869 3442870 3442871 3442872 3442873 3442874 3442876 3442877 3442878 3442879 3442880 3442881 3442882 3442883 3442884 3442885 3442886 3442889 3442892 3442922 3442923 36979_at 42945_at 56198_at 6515 68593_at 7960865 A_23_P139669 A_24_P81900 GE57861 GE84815 GO:0003013 GO:0005354 GO:0005515 GO:0005536 GO:0005886 GO:0005975 GO:0015757 GO:0016020 GO:0016235 GO:0019852 GO:0022857 GO:0030667 GO:0033300 GO:0035579 GO:0042995 GO:0043204 GO:0046323 GO:0055056 GO:0055085 GO:0070062 GO:0070821 GO:0070837 GO:0098708 GO:0101003 GO:0150104 GO:1904659 HMNXSV003002951 HMNXSV003010684 Hs.192123.0.A1_3p_at Hs.7594.0.A2_3p_a_at Hs.7594.1.A1_3p_a_at Hs.7594.2.A1_3p_a_at M20681_at PH_hs_0025111 PH_hs_0041090 TC12001170.hg TC12002734.hg g5902089_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6801040] SLC2A3 [ficolin-1-rich granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800180] SLC2A3 [tertiary granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800184] SLC2A3 [specific granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800892] SLC2A3 [secretory granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-70407] SLC2A3 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12712612] UCSC:P11169 SLC2A3 [ReferenceDNASequence:12111497] OMIM:138170 SLC2A3 [ReferenceDNASequence:12094105] NCBI Gene:6515 SLC2A3 [ReferenceDNASequence:12010012] Monarch:6515 SLC2A3 [ReferenceDNASequence:11917249] KEGG:hsa:6515 SLC2A3 [ReferenceDNASequence:11820549] HGNC:11007 SLC2A3 [ReferenceDNASequence:11431918] dbSNP Gene:6515 SLC2A3 [ReferenceDNASequence:11415370] CTD Gene:6515 SLC2A3 [ReferenceDNASequence:11395665] COSMIC - genes:SLC2A3 SLC2A3 [ReferenceDNASequence:11380223] BioGPS Gene:6515 SLC2A3 [ReferenceDNASequence:ensembl:ENSG00000059804] ENSEMBL:ENSG00000059804 SLC2A3
referenceTranscript	[ReferenceRNASequence:12641941] RefSeq:NM_006931.3 SLC2A3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GTR3_HUMAN B2R606 D3DUU6 Q6I9U2 Q9UG15
sequenceLength	496
species	[Species:48887] Homo sapiens
stId	uniprot:P11169
url	http://purl.uniprot.org/uniprot/P11169

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