Reactome | UniProt:P10827-2 THRA

chain	chain:1-490
checksum	C87C7D2F67B1AE49
comment	FUNCTION Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.FUNCTION Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.SUBUNIT Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2. Isoform alpha-2 and isoform alpha-1 interact with TACC1, but the interaction with alpha-1 is weaker. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (PubMed:20078863).INTERACTION When overexpressed found in the cytoplasm where it colocalizes with TACC1.ALTERNATIVE PRODUCTS Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Does not bind thyroid hormone T3.SIMILARITY Belongs to the nuclear hormone receptor family. NR1 subfamily.
crossReference	[DatabaseIdentifier:12332339] RefSeq:NP_003241.2 [DatabaseIdentifier:12817733] ZINC - World Drugs:THA_HUMAN [DatabaseIdentifier:12816016] ZINC target:P10827 [DatabaseIdentifier:12812641] ZINC - Substances:THA_HUMAN [DatabaseIdentifier:12808155] ZINC - Predictions - Purchasable:THA_HUMAN [DatabaseIdentifier:12807418] ZINC - Metabolites:THA_HUMAN [DatabaseIdentifier:12806279] ZINC - Investigational:THA_HUMAN [DatabaseIdentifier:12805227] ZINC - FDA approved:THA_HUMAN [DatabaseIdentifier:12804008] ZINC - Biogenic:THA_HUMAN [DatabaseIdentifier:12332343] RefSeq:NP_001177847.1 [DatabaseIdentifier:12332344] RefSeq:XP_054173007.1 [DatabaseIdentifier:12332342] RefSeq:XP_047292588.1 [DatabaseIdentifier:12332340] RefSeq:NP_955366.1 [DatabaseIdentifier:12332341] RefSeq:NP_001177848.1 [DatabaseIdentifier:11456220] ENSEMBL:ENSG00000126351 [DatabaseIdentifier:11547203] ENSEMBL:ENSP00000377679 [DatabaseIdentifier:11547205] ENSEMBL:ENSP00000264637 [DatabaseIdentifier:11547204] ENSEMBL:ENSP00000395641 [DatabaseIdentifier:11547206] ENSEMBL:ENSP00000463466 [DatabaseIdentifier:11547207] ENSEMBL:ENSP00000443972 [DatabaseIdentifier:11669903] ENSEMBL:ENST00000546243 [DatabaseIdentifier:11669902] ENSEMBL:ENST00000584985 [DatabaseIdentifier:11669904] ENSEMBL:ENST00000394121 [DatabaseIdentifier:11669905] ENSEMBL:ENST00000450525 [DatabaseIdentifier:11669906] ENSEMBL:ENST00000264637 [DatabaseIdentifier:11778643] Guide to Pharmacology - Targets:588 [DatabaseIdentifier:11790681] GeneCards:THRA [DatabaseIdentifier:11831940] HMDB Protein:HMDBP10713 [DatabaseIdentifier:11843685] HPA:ENSG00000126351-THRA [DatabaseIdentifier:12128299] OpenTargets:ENSG00000126351 [DatabaseIdentifier:12136614] Orphanet:THRA [DatabaseIdentifier:12204247] PDB:3JZB [DatabaseIdentifier:12204246] PDB:1NAV [DatabaseIdentifier:12204243] PDB:7QDT [DatabaseIdentifier:12204244] PDB:2H77 [DatabaseIdentifier:12204245] PDB:8RQO [DatabaseIdentifier:12204248] PDB:3HZF [DatabaseIdentifier:12204249] PDB:4LNW [DatabaseIdentifier:12204250] PDB:4LNX [DatabaseIdentifier:12204251] PDB:3ILZ [DatabaseIdentifier:12204252] PDB:2H79 [DatabaseIdentifier:12249780] PRO:P10827 [DatabaseIdentifier:12288521] Pharos - Targets:P10827
databaseName	UniProt
dbId	154879
description	recommendedName: Thyroid hormone receptor alpha alternativeName: Nuclear receptor subfamily 1 group A member 1 alternativeName: V-erbA-related protein 7 shortName: EAR-7 alternativeName: c-erbA-1 alternativeName: c-erbA-alpha
displayName	UniProt:P10827-2 THRA
geneName	THRA EAR7 ERBA1 NR1A1 THRA1 THRA2
identifier	P10827
isSequenceChanged	false
isoformParent	[ReferenceGeneProduct:uniprot:P10827] UniProt:P10827 THRA
keyword	3D-structure Alternative splicing Congenital hypothyroidism Cytoplasm Disease variant DNA-binding Metal-binding Nucleus Proteomics identification Receptor Reference proteome Transcription Transcription regulation Zinc Zinc-finger
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	THRA
otherIdentifier	11717773_a_at 11734119_a_at 11734120_x_at 11747680_a_at 11747681_x_at 11750897_a_at 11759126_a_at 11761993_a_at 1316_PM_at 1316_at 16833965 204100_PM_at 204100_at 214883_PM_at 214883_at 35846_PM_at 35846_at 3720696 3720697 3720698 3720702 3720703 3720705 3720706 3720707 3720708 3720709 3720710 3720711 3720712 3720713 3720714 3720715 3720716 3720717 3720718 3720719 3720720 3720721 3720722 3720723 3720724 3720725 3720727 3720729 4898680_3p_at 616_s_at 7067 8007008 86815_at A_14_P108110 A_14_P130248 A_14_P200471 A_23_P207742 A_24_P262407 GE81253 GO:0000122 GO:0000785 GO:0000976 GO:0000978 GO:0000981 GO:0001502 GO:0001503 GO:0002154 GO:0002155 GO:0002157 GO:0003677 GO:0003700 GO:0004879 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0007611 GO:0008016 GO:0008050 GO:0008270 GO:0009409 GO:0009755 GO:0009887 GO:0016071 GO:0017025 GO:0017055 GO:0019904 GO:0022414 GO:0030154 GO:0030218 GO:0030522 GO:0030878 GO:0031490 GO:0033032 GO:0042789 GO:0043565 GO:0044877 GO:0045892 GO:0045925 GO:0045944 GO:0046872 GO:0048384 GO:0048856 GO:0050877 GO:0050994 GO:0060509 GO:0070324 GO:0090575 GO:0120162 GO:0140296 GO:2000143 HMNXSV003009754 HMNXSV003017851 ILMN_1654613 ILMN_1661683 ILMN_1718182 M24748_cds2_s_at M24899_at PH_hs_0030854 TC17000488.hg TC17002195.hg TC17002196.hg X55005_rna1_at X55005mRNA_3p_s_at g4507494_3p_s_at p27287
physicalEntity	[EntityWithAccessionedSequence:R-HSA-4719404] THRA-2 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4719442] monoSUMO1-K283,K389-THRA-2 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4719416] polySUMO3-K283,K389-THRA-2 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000126351] ENSEMBL:ENSG00000126351 THRA [ReferenceDNASequence:12676245] UCSC:P10827 THRA [ReferenceDNASequence:11321035] BioGPS Gene:7067 THRA [ReferenceDNASequence:11391548] COSMIC - genes:THRA THRA [ReferenceDNASequence:11418164] CTD Gene:7067 THRA [ReferenceDNASequence:11427196] dbSNP Gene:7067 THRA [ReferenceDNASequence:11822342] HGNC:11796 THRA [ReferenceDNASequence:11863814] KEGG:hsa:7067 THRA [ReferenceDNASequence:11950824] Monarch:7067 THRA [ReferenceDNASequence:12034917] NCBI Gene:7067 THRA [ReferenceDNASequence:12113074] OMIM:190120 THRA
referenceTranscript	[ReferenceRNASequence:12514224] RefSeq:NM_199334.5 THRA [ReferenceRNASequence:12514222] RefSeq:NM_001190918.2 THRA [ReferenceRNASequence:12514226] RefSeq:XM_047436632.1 THRA [ReferenceRNASequence:12514227] RefSeq:NM_003250.5 THRA [ReferenceRNASequence:12514225] RefSeq:XM_054317032.1 THRA [ReferenceRNASequence:12514223] RefSeq:NM_001190919.2 THRA
schemaClass	ReferenceIsoform
secondaryIdentifier	THA_HUMAN A8K3B5 P21205 Q8N6A1 Q96H73
sequenceLength	490
species	[Species:48887] Homo sapiens
stId	uniprot:P10827-2
url	http://purl.uniprot.org/uniprot/P10827-2
variantIdentifier	P10827-2

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-4719404] THRA-2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4719442] monoSUMO1-K283,K389-THRA-2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4719416] polySUMO3-K283,K389-THRA-2 [nucleoplasm]
(referenceSequence)	[GroupModifiedResidue:4719420] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 389 [GroupModifiedResidue:4719408] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 283 [GroupModifiedResidue:4719417] sumoylated lysine (polySUMO3 [nucleoplasm]) at 389 [GroupModifiedResidue:4719427] sumoylated lysine (polySUMO3 [nucleoplasm]) at 283

UniProt:P10827-2 THRA Show undefined attributes

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