UniProt:P10696 ALPG

chain
  • signal peptide:1-19
  • chain:20-503
  • propeptide:504-532
checksum 25EB56C901B61505
comment
  • FUNCTION Alkaline phosphatase that can hydrolyze various phosphate compounds.CATALYTIC ACTIVITY a phosphate monoester + H2O = an alcohol + phosphateCOFACTOR Binds 1 Mg(2+) ion.COFACTOR Binds 2 Zn(2+) ions.COFACTOR Inhibited by L-leucine, EDTA and heat.SUBUNIT Homodimer.SUBCELLULAR LOCATION Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.MISCELLANEOUS In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP).SIMILARITY Belongs to the alkaline phosphatase family.
crossReference
databaseName UniProt
dbId 62038
description
  • recommendedName: fullName evidence="14"Alkaline phosphatase, germ cell type ecNumber evidence="5 9"3.1.3.1 alternativeName: ALP-1 alternativeName: Alkaline phosphatase Nagao isozyme alternativeName: Alkaline phosphatase, placental-like alternativeName: fullName evidence="13"Germ cell alkaline phosphatase shortName evidence="13"GCAP alternativeName: Placental alkaline phosphatase-like shortName: PLAP-like
displayName UniProt:P10696 ALPG
geneName
  • ALPG
  • ALPPL
  • ALPPL2
identifier P10696
isSequenceChanged false
keyword
  • Calcium
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • GPI-anchor
  • Hydrolase
  • Lipoprotein
  • Magnesium
  • Membrane
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Signal
  • Zinc
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ALPG
otherIdentifier
  • 11727334_at
  • 16892246
  • 210431_PM_at
  • 210431_at
  • 211619_PM_s_at
  • 211619_s_at
  • 216377_3p_x_at
  • 216377_PM_x_at
  • 216377_x_at
  • 251
  • 2532277
  • 2532278
  • 2532279
  • 2532280
  • 2532282
  • 2532284
  • 2532285
  • 2532286
  • 2532287
  • 2532288
  • 2532290
  • 2532297
  • 2532298
  • 2532299
  • 2532300
  • 2532301
  • 2532302
  • 2532303
  • 2532304
  • 2532305
  • 2532306
  • 2532307
  • 2532308
  • 2532309
  • 2532310
  • 2532311
  • 678_at
  • 8049128
  • 80616_at
  • 8180197
  • A_23_P68183
  • A_24_P131580
  • GO:0004035
  • GO:0005576
  • GO:0005886
  • GO:0016020
  • GO:0016787
  • GO:0016791
  • GO:0046872
  • GO:0098552
  • HMNXSV003037912
  • HMNXSV003046281
  • Hs.284255.2.S1_3p_s_at
  • J04948_at
  • PH_hs_0029764
  • TC02001399.hg
  • g178418_3p_at
  • g178471_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PPBN_HUMAN
  • A8KAF2
  • Q16727
  • Q53S81
  • Q96CM1
sequenceLength 532
species [Species:48887] Homo sapiens
stId uniprot:P10696
url http://purl.uniprot.org/uniprot/P10696
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