Reactome | UniProt:P10275 AR

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UniProt:P10275 AR Show undefined attributes

chain	chain:1-920
checksum	A73432C55D39AE06
comment	FUNCTION Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.FUNCTION Lacks the C-terminal ligand-binding domain and therefore constitutively regulates the transcription of a specific set of canonical AR-target genes, including PSA/KLK3 and TMPRSS2, independently of steroid hormones (PubMed:19244107, PubMed:25008967). However, some genes are differentially regulated by full-length AR (isoform 1) and isoform 3. Isoform 3-specific target genes may be regulated independently of FOXA1 expression (PubMed:25008967).FUNCTION Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.ACTIVITY REGULATION AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine) suppresses TNK2-mediated phosphorylation at Tyr-269. Inhibits the binding of the Tyr-269 phosphorylated form to androgen-responsive enhancers (AREs) and its transcriptional activity.SUBUNIT Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (via macro domain) (PubMed:19022849). Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3 and MAGEA11. Interacts (via nuclear receptor DNA binding domain and nuclear receptor ligand binding domain) with NCOA4 (PubMed:15563469, PubMed:8643607). The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. Interacts with CCAR1 and GATA2. Interacts with ZNF318 (By similarity). Interacts with BUD31 (PubMed:25091737). Interacts with ARID4A (PubMed:23487765). Interacts with ARID4B (By similarity). Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (PubMed:20812024). Interacts with NCOR1 (PubMed:20812024). Interacts with NCOR2 (PubMed:20812024). Interacts with CRY2 in a ligand-dependent manner (By similarity). Interacts (via NR LBD domain) with RWDD1; the interaction is direct and may stimulate AR activity (PubMed:22406838).INTERACTION Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.ALTERNATIVE PRODUCTS Mainly expressed in heart and skeletal muscle.TISSUE SPECIFICITY Expressed in basal and stromal cells of the prostate (at protein level).DOMAIN Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins (PubMed:25091737). Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain.PTM Sumoylated on Lys-388 (major) and Lys-521. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity.PTM Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-535 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity and may be responsible for androgen-independent progression of prostate cancer. Phosphorylation at Ser-83 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition.PTM Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.POLYMORPHISM The poly-Gln region of AR is highly polymorphic and the number of Gln varies in the population (from 17 to 26). A smaller size of the poly-Gln region may be associated with the development of prostate cancer. Long poly-Gln alleles (>23) may be associated with higher testosterone levels and severe clinical outcome in COVID-19 disease (PubMed:33647767).POLYMORPHISM The poly-Gly region of AR is polymorphic and ranges from 24 to 31 Gly. A poly-Gly region shorter or equal to 23 may be associated with the development of androgenetic alopecia.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.MISCELLANEOUS Transcriptional activity is enhanced by binding to RANBP9.MISCELLANEOUS The level of tyrosine phosphorylation may serve as a diagnostic tool to predict patient outcome in response to hormone-ablation therapy. Inhibition of tyrosine phosphorylation may be an effective intervention target for hormone-refractory prostate cancer.MISCELLANEOUS Minor isoform up-regulated in prostate cancer cells.MISCELLANEOUS Minor isoform identified in prostate cancer cells.SIMILARITY Belongs to the nuclear hormone receptor family. NR3 subfamily.CAUTION Had previously been shown to interact with PELP1. However this paper was retracted as cell-based data was viewed as unreliable.ONLINE INFORMATION Androgen receptor entryONLINE INFORMATION Leiden Open Variation Database (LOVD)
crossReference	[DatabaseIdentifier:11455804] ENSEMBL:ENSG00000169083 [DatabaseIdentifier:12818625] ZINC - World Drugs:ANDR_HUMAN [DatabaseIdentifier:12815720] ZINC target:P10275 [DatabaseIdentifier:12812353] ZINC - Substances:ANDR_HUMAN [DatabaseIdentifier:12810589] ZINC - Predictions - Purchasable:ANDR_HUMAN [DatabaseIdentifier:12807710] ZINC - Metabolites:ANDR_HUMAN [DatabaseIdentifier:12807065] ZINC - Investigational:ANDR_HUMAN [DatabaseIdentifier:12805974] ZINC - FDA approved:ANDR_HUMAN [DatabaseIdentifier:12804907] ZINC - Biogenic:ANDR_HUMAN [DatabaseIdentifier:12331345] RefSeq:NP_001334990.1 [DatabaseIdentifier:12331344] RefSeq:NP_001011645.1 [DatabaseIdentifier:12331343] RefSeq:NP_001334993.1 [DatabaseIdentifier:12331342] RefSeq:NP_001334992.1 [DatabaseIdentifier:12331346] RefSeq:NP_000035.2 [DatabaseIdentifier:12288282] Pharos - Targets:P10275 [DatabaseIdentifier:12249400] PRO:P10275 [DatabaseIdentifier:12203209] PDB:8FH0 [DatabaseIdentifier:12203177] PDB:4OK1 [DatabaseIdentifier:12203203] PDB:2Z4J [DatabaseIdentifier:12141537] PDB:1T5Z [DatabaseIdentifier:12203185] PDB:4OLM [DatabaseIdentifier:12203215] PDB:3B65 [DatabaseIdentifier:12203193] PDB:1T65 [DatabaseIdentifier:12203212] PDB:4OEA [DatabaseIdentifier:12203217] PDB:1XOW [DatabaseIdentifier:12203169] PDB:1Z95 [DatabaseIdentifier:12203180] PDB:8RM7 [DatabaseIdentifier:12203175] PDB:2AMA [DatabaseIdentifier:12203179] PDB:2YHD [DatabaseIdentifier:12203207] PDB:3B67 [DatabaseIdentifier:12203200] PDB:5VO4 [DatabaseIdentifier:12203165] PDB:7ZU1 [DatabaseIdentifier:12203211] PDB:2AXA [DatabaseIdentifier:12147065] PDB:3BTR [DatabaseIdentifier:12151934] PDB:4OH6 [DatabaseIdentifier:12203172] PDB:4OFU [DatabaseIdentifier:12203219] PDB:2AX7 [DatabaseIdentifier:12203201] PDB:1GS4 [DatabaseIdentifier:12203182] PDB:4OFR [DatabaseIdentifier:12203199] PDB:4OKW [DatabaseIdentifier:12203189] PDB:4OH5 [DatabaseIdentifier:12203206] PDB:8E1A [DatabaseIdentifier:12203167] PDB:2PKL [DatabaseIdentifier:12203205] PDB:2AX9 [DatabaseIdentifier:12203197] PDB:4OKT [DatabaseIdentifier:12203188] PDB:3V49 [DatabaseIdentifier:12203186] PDB:3V4A [DatabaseIdentifier:12203178] PDB:8RM6 [DatabaseIdentifier:12203218] PDB:2AX8 [DatabaseIdentifier:12203220] PDB:2AX6 [DatabaseIdentifier:12203214] PDB:3B5R [DatabaseIdentifier:12203187] PDB:4OHA [DatabaseIdentifier:12203190] PDB:4OKX [DatabaseIdentifier:12203192] PDB:7ZTZ [DatabaseIdentifier:12203204] PDB:4OIL [DatabaseIdentifier:12203194] PDB:1T63 [DatabaseIdentifier:12203174] PDB:2YLP [DatabaseIdentifier:12203168] PDB:2OZ7 [DatabaseIdentifier:12203176] PDB:2YLQ [DatabaseIdentifier:12151936] PDB:4OKB [DatabaseIdentifier:12203183] PDB:2AO6 [DatabaseIdentifier:12140934] PDB:3L3X [DatabaseIdentifier:12203184] PDB:5CJ6 [DatabaseIdentifier:12203195] PDB:4K7A [DatabaseIdentifier:12203202] PDB:8FH2 [DatabaseIdentifier:12151935] PDB:4OED [DatabaseIdentifier:12203198] PDB:7ZTX [DatabaseIdentifier:12203216] PDB:3B66 [DatabaseIdentifier:12203173] PDB:2AMB [DatabaseIdentifier:12203210] PDB:8FH1 [DatabaseIdentifier:12203196] PDB:7ZU2 [DatabaseIdentifier:12140937] PDB:3L3Z [DatabaseIdentifier:12203191] PDB:4QL8 [DatabaseIdentifier:12203170] PDB:2PNU [DatabaseIdentifier:12203171] PDB:2YLO [DatabaseIdentifier:12203166] PDB:3RLL [DatabaseIdentifier:12203213] PDB:3ZQT [DatabaseIdentifier:12203208] PDB:3B68 [DatabaseIdentifier:12203181] PDB:1E3G [DatabaseIdentifier:12203137] PDB:2Q7J [DatabaseIdentifier:12203146] PDB:2PIP [DatabaseIdentifier:12203151] PDB:4OEY [DatabaseIdentifier:12203163] PDB:4OGH [DatabaseIdentifier:12203145] PDB:2PIQ [DatabaseIdentifier:12203159] PDB:2PIT [DatabaseIdentifier:12203147] PDB:4OJ9 [DatabaseIdentifier:12203157] PDB:2PIU [DatabaseIdentifier:12203158] PDB:1XQ3 [DatabaseIdentifier:12203150] PDB:5T8E [DatabaseIdentifier:12203135] PDB:5V8Q [DatabaseIdentifier:12203152] PDB:2PIX [DatabaseIdentifier:12203143] PDB:2AM9 [DatabaseIdentifier:12203164] PDB:3RLJ [DatabaseIdentifier:12203156] PDB:2PIV [DatabaseIdentifier:12203161] PDB:5JJM [DatabaseIdentifier:12203155] PDB:8FGZ [DatabaseIdentifier:12203144] PDB:2PIR [DatabaseIdentifier:12203134] PDB:2Q7L [DatabaseIdentifier:12203148] PDB:2PIO [DatabaseIdentifier:12203139] PDB:4HLW [DatabaseIdentifier:12203138] PDB:2Q7I [DatabaseIdentifier:12203136] PDB:2Q7K [DatabaseIdentifier:12203160] PDB:4OIU [DatabaseIdentifier:12203154] PDB:2PIW [DatabaseIdentifier:12203162] PDB:1XJ7 [DatabaseIdentifier:12203142] PDB:4OJB [DatabaseIdentifier:12203140] PDB:4OEZ [DatabaseIdentifier:12203153] PDB:8FGY [DatabaseIdentifier:12203141] PDB:5T8J [DatabaseIdentifier:12203149] PDB:2HVC [DatabaseIdentifier:12136328] Orphanet:AR [DatabaseIdentifier:12128058] OpenTargets:ENSG00000169083 [DatabaseIdentifier:11843448] HPA:ENSG00000169083-AR [DatabaseIdentifier:11831491] HMDB Protein:HMDBP01624 [DatabaseIdentifier:11790440] GeneCards:AR [DatabaseIdentifier:11781038] Guide to Pharmacology - Targets:628 [DatabaseIdentifier:11669261] ENSEMBL:ENST00000612452 [DatabaseIdentifier:11669262] ENSEMBL:ENST00000504326 [DatabaseIdentifier:11669260] ENSEMBL:ENST00000374690 [DatabaseIdentifier:11546563] ENSEMBL:ENSP00000363822 [DatabaseIdentifier:11546562] ENSEMBL:ENSP00000484033 [DatabaseIdentifier:11546561] ENSEMBL:ENSP00000421155
databaseName	UniProt
dbId	49978
description	recommendedName: Androgen receptor alternativeName: Dihydrotestosterone receptor alternativeName: Nuclear receptor subfamily 3 group C member 4
displayName	UniProt:P10275 AR
geneName	AR DHTR NR3C4
identifier	P10275
isSequenceChanged	false
keyword	3D-structure Activator Alternative splicing Cytoplasm Disease variant DNA-binding Isopeptide bond Lipid-binding Lipoprotein Metal-binding Neurodegeneration Nucleus Palmitate Phosphoprotein Proteomics identification Pseudohermaphroditism Receptor Reference proteome Steroid-binding Transcription Transcription regulation Triplet repeat expansion Ubl conjugation Zinc Zinc-finger
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	AR
otherIdentifier	11737903_a_at 11742471_a_at 11752265_a_at 11762394_a_at 1577_at 1578_g_at 17104313 211110_PM_s_at 211110_s_at 226192_PM_at 226192_at 226197_PM_at 226197_at 367 3979915 3979916 3979917 3979918 3979919 3979920 3979921 3979922 3979923 3979924 3979925 3979926 3979927 3979928 3979929 3979930 3979931 3979932 3979933 3979934 3979942 3979955 3979956 3979960 3979961 3979963 3979964 3979965 3979968 3979970 3979971 3979972 3979973 3979975 3979977 3979978 3979979 3979980 3979981 3979982 3979983 3979988 3979989 3979990 3979992 43435_at 43436_g_at 52851_at 52853_g_at 8167998 A_14_P120121 A_14_P201842 A_23_P113111 GE58203 GE87814 GO:0000122 GO:0000165 GO:0000785 GO:0000976 GO:0000977 GO:0000978 GO:0000979 GO:0000981 GO:0001091 GO:0001223 GO:0001228 GO:0001701 GO:0003073 GO:0003382 GO:0003677 GO:0003682 GO:0003700 GO:0003707 GO:0004879 GO:0005102 GO:0005496 GO:0005497 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0007165 GO:0007267 GO:0007283 GO:0007338 GO:0008013 GO:0008270 GO:0008284 GO:0008285 GO:0008289 GO:0008584 GO:0009566 GO:0010467 GO:0010468 GO:0010628 GO:0016607 GO:0019102 GO:0019899 GO:0022414 GO:0030154 GO:0030518 GO:0030520 GO:0030521 GO:0030522 GO:0032991 GO:0033148 GO:0033327 GO:0033574 GO:0034056 GO:0035264 GO:0043410 GO:0043565 GO:0043568 GO:0045597 GO:0045726 GO:0045893 GO:0045944 GO:0045945 GO:0046872 GO:0048009 GO:0048608 GO:0048638 GO:0048645 GO:0048808 GO:0048856 GO:0050673 GO:0050680 GO:0051117 GO:0060090 GO:0060514 GO:0060571 GO:0060599 GO:0060685 GO:0060736 GO:0060740 GO:0060742 GO:0060748 GO:0060749 GO:0060769 GO:0061458 GO:0061629 GO:0070974 GO:0071383 GO:0071391 GO:0071394 GO:0072520 GO:0140693 GO:0140694 GO:1901654 GO:1902895 GO:1903076 GO:1990837 GO:2001237 HMNXSV003053460 Hs.76704.0.A1_3p_at Hs.76704.0.A2_3p_at ILMN_1659572 ILMN_1767351 ILMN_1792540 M23263_at M35851_s_at PH_hs_0005583 TC0X000358.hg g178655_3p_at g5639998_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-446174] AR [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5618082] AR [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4090320] monoSUMO1-K386,520-AR [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6782984] PolyUb-AR [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000169083] ENSEMBL:ENSG00000169083 AR [ReferenceDNASequence:12676048] UCSC:P10275 AR [ReferenceDNASequence:12112865] OMIM:313700 AR [ReferenceDNASequence:12034534] NCBI Gene:367 AR [ReferenceDNASequence:11950441] Monarch:367 AR [ReferenceDNASequence:11863455] KEGG:hsa:367 AR [ReferenceDNASequence:11822101] HGNC:644 AR [ReferenceDNASequence:11427179] dbSNP Gene:367 AR [ReferenceDNASequence:11417815] CTD Gene:367 AR [ReferenceDNASequence:11391534] COSMIC - genes:AR AR [ReferenceDNASequence:11320652] BioGPS Gene:367 AR
referenceTranscript	[ReferenceRNASequence:12513247] RefSeq:NM_000044.4 AR [ReferenceRNASequence:12513250] RefSeq:NM_001348064.1 AR [ReferenceRNASequence:12513251] RefSeq:NM_001348063.1 AR [ReferenceRNASequence:12513248] RefSeq:NM_001011645.3 AR [ReferenceRNASequence:12513249] RefSeq:NM_001348061.1 AR
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ANDR_HUMAN A0A0B4J1T2 A2RUN2 B1AKD7 C0JKD3 C0JKD4 E7EVX6 Q9UD95
sequenceLength	920
species	[Species:48887] Homo sapiens
stId	uniprot:P10275
url	http://purl.uniprot.org/uniprot/P10275

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-446174] AR [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5618082] AR [cytosol] [EntityWithAccessionedSequence:R-HSA-4090320] monoSUMO1-K386,520-AR [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6782984] PolyUb-AR [nucleoplasm]
(referenceSequence)	[GroupModifiedResidue:4090410] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 386 [GroupModifiedResidue:4090371] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 520 [GroupModifiedResidue:6782956] ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position
(interactor)	[UndirectedInteraction:11268613] UniProt:P10275 <-> UniProt:P17535 (IntAct) [UndirectedInteraction:11268611] UniProt:P10275 <-> UniProt:Q9NPF5 (IntAct) [UndirectedInteraction:11268609] UniProt:P10275 <-> UniProt:Q6KC79 (IntAct) [UndirectedInteraction:11268607] UniProt:P10275 <-> UniProt:Q9UBS8 (IntAct) [UndirectedInteraction:11268605] UniProt:P10275 <-> UniProt:Q92993 (IntAct) [UndirectedInteraction:11268603] UniProt:P10275 <-> UniProt:P20711 (IntAct) [UndirectedInteraction:11268601] UniProt:P10275 <-> UniProt:Q9BY66-3 (IntAct) [UndirectedInteraction:11268597] UniProt:P10275 <-> UniProt:P78543 (IntAct) [UndirectedInteraction:11268595] UniProt:P10275 <-> UniProt:Q16666 (IntAct) [UndirectedInteraction:11268593] UniProt:P10275 <-> UniProt:Q9NSA3 (IntAct) [UndirectedInteraction:11268591] UniProt:P10275 <-> UniProt:P20794 (IntAct) [UndirectedInteraction:11268589] UniProt:P10275 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11268589] UniProt:P10275 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11268587] UniProt:P10275 <-> IntAct:EBI-2678840 (IntAct) [UndirectedInteraction:11268583] UniProt:P10275 <-> UniProt:Q06986 (IntAct) [UndirectedInteraction:11268581] UniProt:P10275 <-> UniProt:O14595 (IntAct) [UndirectedInteraction:11142673] UniProt:Q9UBL3 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11142947] UniProt:O75376 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11146513] UniProt:Q02790 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11146747] UniProt:Q93074 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11147233] UniProt:Q9Y6Q9 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11155267] UniProt:Q99497 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11155579] UniProt:P56524 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11169623] UniProt:Q9UER7 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11183757] UniProt:P63165 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11184953] UniProt:Q06830 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11186605] UniProt:Q14686 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11191895] UniProt:O14686 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11195997] UniProt:P24385 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11197817] UniProt:O75593 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11207199] UniProt:Q15788 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11211461] UniProt:Q9Y253 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11212097] UniProt:P06396 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11216435] UniProt:P78527 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11242353] UniProt:O43474 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11246209] UniProt:Q14192 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11247385] UniProt:Q15910 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11256343] UniProt:O96028 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11258587] UniProt:Q15648 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11258861] UniProt:Q92793 <-> UniProt:P10275 (IntAct) [UndirectedInteraction:11268549] UniProt:P10275 <-> IntAct:EBI-1776214 (IntAct) [UndirectedInteraction:11268551] UniProt:P10275 <-> UniProt:P35222 (IntAct) [UndirectedInteraction:11268553] UniProt:P10275 <-> IntAct:EBI-2602074 (IntAct) [UndirectedInteraction:11268555] UniProt:P10275 <-> UniProt:P55317 (IntAct) [UndirectedInteraction:11268557] UniProt:P10275 <-> UniProt:Q15596 (IntAct) [UndirectedInteraction:11268559] UniProt:P10275 <-> UniProt:P11308 (IntAct) [UndirectedInteraction:11268561] UniProt:P10275 <-> UniProt:O60885-1 (IntAct) [UndirectedInteraction:11268565] UniProt:P10275 <-> IntAct:EBI-2677345 (IntAct) [UndirectedInteraction:11268567] UniProt:P10275 <-> UniProt:Q03164 (IntAct) [UndirectedInteraction:11268569] UniProt:P10275 <-> UniProt:Q15652 (IntAct) [UndirectedInteraction:11268571] UniProt:P10275 <-> UniProt:P07288 (IntAct) [UndirectedInteraction:11268573] UniProt:P10275 <-> UniProt:Q15797 (IntAct) [UndirectedInteraction:11268575] UniProt:P10275 <-> UniProt:O95251 (IntAct) [UndirectedInteraction:11268577] UniProt:P10275 <-> UniProt:Q9R1E0 (IntAct) [UndirectedInteraction:11268579] UniProt:P10275 <-> UniProt:Q9Y252 (IntAct)