UniProt:P0DOY3 IGLC3

chain
  • chain:1-106
checksum 145272BBE65F4565
comment
  • FUNCTION Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGLC3*03.MISCELLANEOUS Alleles IGLC3*01, IGLC3*02, and IGLC3*03 display the following serological isotype: Mcg-, Kern- and Oz+. The Mcg-isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz+ marker by Lys-83. Allele IGLC3*04 displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.CAUTION For an example of a full-length immunoglobulin lambda light chain see AC P0DOX8.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:8987656] Weiser, JD
crossReference
databaseName UniProt
dbId 8998365
description
  • recommendedName: fullName evidence="2 7"Immunoglobulin lambda constant 3 alternativeName: fullName evidence="10"Ig lambda chain C region DOT alternativeName: fullName evidence="9"Ig lambda chain C region NEWM alternativeName: fullName evidence="8"Ig lambda-3 chain C regions
displayName UniProt:P0DOY3 IGLC3
geneName
  • IGLC3
identifier P0DOY3
isSequenceChanged false
keyword
  • 3D-structure
  • Adaptive immunity
  • Bence-Jones protein
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Immunity
  • Immunoglobulin
  • Immunoglobulin domain
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Secreted
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • IGLC3
otherIdentifier
  • 16927858
  • 209138_PM_x_at
  • 209138_x_at
  • 214677_PM_x_at
  • 214677_x_at
  • 215121_PM_x_at
  • 215121_x_at
  • 215379_PM_x_at
  • 215379_x_at
  • 33273_f_at
  • 33274_f_at
  • 3938636
  • 3938637
  • 3938650
  • 3938651
  • 3938652
  • 3938653
  • 3938654
  • 3938655
  • 3938661
  • 3938662
  • 3938663
  • 3938664
  • 3938665
  • 3938666
  • 3938667
  • 3938680
  • 58867_s_at
  • GO:0002250
  • GO:0002376
  • GO:0003823
  • GO:0005576
  • GO:0005615
  • GO:0005886
  • GO:0016020
  • GO:0016064
  • GO:0019814
  • GO:0050853
  • GO:0070062
  • GO:0071735
  • GO:0071738
  • GO:0071742
  • GO:0071745
  • GO:0071753
  • GO:0072562
  • Hs.181125.2.A1_3p_x_at
  • Hs2.383932.1.S1_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IGLC3_HUMAN
  • A0A075B6L0
  • A0M8Q4
  • P0CG05
  • P0CG06
  • P80423
sequenceLength 106
species [Species:48887] Homo sapiens
stId uniprot:P0DOY3
url http://purl.uniprot.org/uniprot/P0DOY3
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