Reactome | UniProt:P0DI81 TRAPPC2

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UniProt:P0DI81 TRAPPC2 Show undefined attributes

chain	chain:1-140
checksum	B099943C6F88952C
comment	FUNCTION Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.SUBUNIT Can homodimerize. Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with ENO1, PITX1 and SF1.INTERACTION Localized in perinuclear granular structures.ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS A paralogous gene encoding an identical protein appears to have arisen by retrotransposition of a cDNA from this locus and to have acquired a promoter and non-coding 5' UTR from the ZNF547 gene.SIMILARITY Belongs to the TRAPP small subunits family. Sedlin subfamily.
created	[InstanceEdit:1995863] Weiser, JD
crossReference	[DatabaseIdentifier:11468119] ENSEMBL:ENSG00000196459 [DatabaseIdentifier:11564125] ENSEMBL:ENSP00000508155 [DatabaseIdentifier:11564123] ENSEMBL:ENSP00000352708 [DatabaseIdentifier:11564121] ENSEMBL:ENSP00000428900 [DatabaseIdentifier:11564124] ENSEMBL:ENSP00000392495 [DatabaseIdentifier:11564122] ENSEMBL:ENSP00000369953 [DatabaseIdentifier:11564126] ENSEMBL:ENSP00000507474 [DatabaseIdentifier:11686823] ENSEMBL:ENST00000458511 [DatabaseIdentifier:11686822] ENSEMBL:ENST00000683983 [DatabaseIdentifier:11686824] ENSEMBL:ENST00000380579 [DatabaseIdentifier:11686825] ENSEMBL:ENST00000518847 [DatabaseIdentifier:11686820] ENSEMBL:ENST00000683569 [DatabaseIdentifier:11686821] ENSEMBL:ENST00000359680 [DatabaseIdentifier:11784970] GeneCards:TRAPPC2 [DatabaseIdentifier:11838057] HPA:ENSG00000196459-TRAPPC2 [DatabaseIdentifier:12122560] OpenTargets:ENSG00000196459 [DatabaseIdentifier:12137262] Orphanet:TRAPPC2 [DatabaseIdentifier:12261202] PRO:P0DI81 [DatabaseIdentifier:12282882] Pharos - Targets:P0DI81 [DatabaseIdentifier:12357554] RefSeq:XP_054183540.1 [DatabaseIdentifier:12357556] RefSeq:NP_001122307.2 [DatabaseIdentifier:12357551] RefSeq:XP_047298307.1 [DatabaseIdentifier:12357552] RefSeq:NP_055378.1 [DatabaseIdentifier:12357553] RefSeq:XP_047298308.1 [DatabaseIdentifier:12357550] RefSeq:XP_054183539.1 [DatabaseIdentifier:12357555] RefSeq:NP_001011658.1 [DatabaseIdentifier:12357557] RefSeq:XP_011543868.1
databaseName	UniProt
dbId	1995988
description	recommendedName: Trafficking protein particle complex subunit 2 alternativeName: Sedlin
displayName	UniProt:P0DI81 TRAPPC2
geneName	TRAPPC2 SEDL
identifier	P0DI81
isSequenceChanged	false
keyword	Alternative splicing Cytoplasm Disease variant ER-Golgi transport Nucleus Phosphoprotein Reference proteome Transcription Transport
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	TRAPPC2
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5683757] TRAPPC2 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000196459] ENSEMBL:ENSG00000196459 TRAPPC2 [ReferenceDNASequence:12683436] UCSC:P0DI81 TRAPPC2 [ReferenceDNASequence:11332884] BioGPS Gene:6399 TRAPPC2 [ReferenceDNASequence:11392396] COSMIC - genes:TRAPPC2 TRAPPC2 [ReferenceDNASequence:11409207] CTD Gene:6399 TRAPPC2 [ReferenceDNASequence:11428170] dbSNP Gene:6399 TRAPPC2 [ReferenceDNASequence:11816595] HGNC:23068 TRAPPC2 [ReferenceDNASequence:11874476] KEGG:hsa:6399 TRAPPC2 [ReferenceDNASequence:11962673] Monarch:6399 TRAPPC2 [ReferenceDNASequence:12046766] NCBI Gene:6399 TRAPPC2 [ReferenceDNASequence:12108159] OMIM:300202 TRAPPC2
referenceTranscript	[ReferenceRNASequence:12539400] RefSeq:XM_047442352.1 TRAPPC2 [ReferenceRNASequence:12539401] RefSeq:XM_011545566.3 TRAPPC2 [ReferenceRNASequence:12539397] RefSeq:NM_014563.6 TRAPPC2 [ReferenceRNASequence:12539402] RefSeq:NM_001128835.3 TRAPPC2 [ReferenceRNASequence:12539398] RefSeq:XM_047442351.1 TRAPPC2 [ReferenceRNASequence:12539399] RefSeq:XM_054327565.1 TRAPPC2 [ReferenceRNASequence:12539395] RefSeq:NM_001011658.4 TRAPPC2 [ReferenceRNASequence:12539396] RefSeq:XM_054327564.1 TRAPPC2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TPC2A_HUMAN A6NEG0 O14582 Q9HD16
sequenceLength	140
species	[Species:48887] Homo sapiens
stId	uniprot:P0DI81
url	http://purl.uniprot.org/uniprot/P0DI81

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5683757] TRAPPC2 [cytosol]
(interactor)	[UndirectedInteraction:11249545] UniProt:Q9UBC2 <-> UniProt:P0DI81 (IntAct) [UndirectedInteraction:11256207] UniProt:Q719H9 <-> UniProt:P0DI81 (IntAct) [UndirectedInteraction:11307379] UniProt:Q96QF0 <-> UniProt:P0DI81 (IntAct)

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