UniProt:P0C6B2 Ptcra

chain
  • signal peptide:1-16
  • chain:17-199
checksum 5141E9361BF494BA
comment
  • FUNCTION Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that plays a crucial role in early T-cell development, particularly alpha-beta T cell differentiation (PubMed:9647201, PubMed:7596413). Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3-TCRB complex.SUBUNIT Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1 (By similarity).SUBCELLULAR LOCATION Isoform 1 is expressed at higher levels than isoform 2 in the thymus while only isoform 2 is expressed in polyclonal beta-only cells. Isoform 1 shows a predominant expression in immature thymocytes.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 244220
description
  • recommendedName: fullName evidence="9"Pre T-cell antigen receptor alpha shortName evidence="9"pT-alpha shortName evidence="9"pTa alternativeName: gp33 alternativeName: pT-alpha-TCR
displayName UniProt:P0C6B2 Ptcra
geneName
  • Ptcra
identifier P0C6B2
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Membrane
  • Receptor
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • Ptcra
otherIdentifier
  • 10451465
  • 1421760_at
  • 17345581
  • 19208
  • 4335460
  • 4363983
  • 4388189
  • 4476580
  • 4585505
  • 4788240
  • 5126716
  • 5265153
  • 5426766
  • 98354_at
  • A_55_P2122884
  • A_66_P128356
  • GE35959
  • GO:0002376
  • GO:0005886
  • GO:0016020
  • GO:0030154
  • GO:0046632
  • GO:0070242
  • GO:0070244
  • ILMN_1245744
  • ILMN_1254670
  • mMC020698
  • u16958_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PTCRA_MOUSE
sequenceLength 199
species [Species:48892] Mus musculus
stId uniprot:P0C6B2
url http://purl.uniprot.org/uniprot/P0C6B2
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