UniProt:P0C0U1 PB1

chain
  • chain:1-87
checksum 832A7E34E350B454
comment
  • FUNCTION Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.SUBUNIT Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS.INTERACTION Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.MISCELLANEOUS Is not encoded in all strains, and seems to be dispensable for replication.SIMILARITY Belongs to the influenza viruses PB1-F2 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 241845
description
  • recommendedName: fullName evidence="1"Protein PB1-F2
displayName UniProt:P0C0U1 PB1
geneName
  • PB1
identifier P0C0U1
isSequenceChanged false
keyword
  • 3D-structure
  • Apoptosis
  • Host cytoplasm
  • Host membrane
  • Host mitochondrion
  • Host mitochondrion inner membrane
  • Host nucleus
  • Host-virus interaction
  • Inhibition of host innate immune response by virus
  • Inhibition of host MAVS by virus
  • Inhibition of host RLR pathway by virus
  • Membrane
  • Modulation of host cell apoptosis by virus
  • Reference proteome
  • Viral immunoevasion
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • PB1
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PB1F2_I34A1
  • A4GXH2
  • Q20N29
sequenceLength 87
species [Species:9031716] Influenza A virus
stId uniprot:P0C0U1
url http://purl.uniprot.org/uniprot/P0C0U1
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