UniProt:P0C0S5 H2AZ1

chain
  • initiator methionine:1
  • chain:2-128
checksum E024E53818230371
comment
  • FUNCTION Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.SUBUNIT The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B. H2AZ1 interacts with INCENP (By similarity). Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AZ1 from the nucleosome. Heterodimer H2BC11 and H2AZ1 interacts with VPS72 (via N-terminal domain) (PubMed:26974126). The interaction of HZAZ1 and VPS72 is enhanced by VPS72 phosphorylation which is promoted by ZNHIT1 (By similarity). Interacts with PWWP2A (PubMed:28645917, PubMed:30327463). Interacts with FH (when phosphorylated by PRKDC) (PubMed:26237645). Interacts with ZNHIT1; the interaction results in recruitment of H2AZ1 to the MYOG promoter region which is required for muscle-specific gene expression (PubMed:20473270).INTERACTION Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.PTM Acetylated on Lys-5, Lys-8, Lys-12 and Lys-14 by KAT2A; KAT2A is recruited by the XPC complex in absence of DNA damage (PubMed:31527837). Acetylated on Lys-5, Lys-8 and Lys-12 during interphase; acetylation disappears at mitosis (By similarity). Acetylation by the NuA4 histone acetyltransferase complex is required for hematopoietic stem cell maintenance (By similarity).PTM Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.PTM Not phosphorylated.PTM Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.MASS SPECTROMETRY Monoisotopic, not modified.SIMILARITY Belongs to the histone H2A family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 231437
description
  • recommendedName: Histone H2A.Z shortName: H2A/z
displayName UniProt:P0C0S5 H2AZ1
geneName
  • H2AZ1
  • H2AFZ
  • H2AZ
identifier P0C0S5
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Chromosome
  • DNA-binding
  • Isopeptide bond
  • Methylation
  • Nucleosome core
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • H2AZ1
otherIdentifier
  • 11729613_a_at
  • 11729614_x_at
  • 11754135_a_at
  • 11756360_x_at
  • 16978334
  • 200853_PM_at
  • 200853_at
  • 213911_PM_s_at
  • 213911_s_at
  • 2779487
  • 2779488
  • 2779489
  • 2779490
  • 2779491
  • 2779492
  • 2779493
  • 2779494
  • 2779495
  • 2779496
  • 2779497
  • 2779498
  • 2779499
  • 2779500
  • 2779501
  • 3015
  • 3405395
  • 39337_at
  • 8101945
  • A_23_P133146
  • A_24_P354468
  • GE62273
  • GO:0000786
  • GO:0000791
  • GO:0000792
  • GO:0000978
  • GO:0000979
  • GO:0003677
  • GO:0005198
  • GO:0005515
  • GO:0005634
  • GO:0005694
  • GO:0006325
  • GO:0006355
  • GO:0030527
  • GO:0031490
  • GO:0031492
  • GO:0031507
  • GO:0045944
  • GO:0046982
  • GO:0070062
  • GO:0071392
  • HMNXSV003049491
  • Hs.119192.1.A1_3p_a_at
  • ILMN_1707858
  • M37583_at
  • PH_hs_0035543
  • TC04001419.hg
  • TC04002644.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • H2AZ_HUMAN
  • B2RD56
  • P17317
  • Q6I9U0
sequenceLength 128
species [Species:48887] Homo sapiens
stId uniprot:P0C0S5
url http://purl.uniprot.org/uniprot/P0C0S5
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