UniProt:P0C0A3 Chmp6

chain
  • initiator methionine:1
  • chain:2-200
checksum 13EE6683997D46C6
comment
  • FUNCTION Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).SUBUNIT Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with SNF8, VPS25 and VPS36 (By similarity).SUBCELLULAR LOCATION Localizes to endosomal membranes.DOMAIN The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity).PTM ISGylated in a CHMP5-dependent manner. Isgylation weakens its interaction with VPS4A (By similarity).SIMILARITY Belongs to the SNF7 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 223445
description
  • recommendedName: Charged multivesicular body protein 6 alternativeName: Chromatin-modifying protein 6
displayName UniProt:P0C0A3 Chmp6
geneName
  • Chmp6
identifier P0C0A3
isSequenceChanged false
keyword
  • Coiled coil
  • Endosome
  • Lipoprotein
  • Membrane
  • Myristate
  • Phosphoprotein
  • Protein transport
  • Reference proteome
  • Transport
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • Chmp6
otherIdentifier
  • 10383282
  • 1433684_at
  • 17259220
  • 208092
  • 4312451
  • 4492570
  • 4497388
  • 4562559
  • 4619268
  • 4641632
  • 4661117
  • 4680537
  • 4799311
  • 4937956
  • 4985879
  • 4992439
  • 5235872
  • 5418015
  • 5514531
  • 5579877
  • 5589574
  • 96097_at
  • A_52_P162538
  • A_55_P2098300
  • A_66_P121474
  • GE1508762
  • GO:0000421
  • GO:0000776
  • GO:0000815
  • GO:0001778
  • GO:0005643
  • GO:0005765
  • GO:0005768
  • GO:0005771
  • GO:0005828
  • GO:0005886
  • GO:0006900
  • GO:0006914
  • GO:0006997
  • GO:0007034
  • GO:0007080
  • GO:0010008
  • GO:0012505
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0030496
  • GO:0031468
  • GO:0031902
  • GO:0032511
  • GO:0032585
  • GO:0036258
  • GO:0039702
  • GO:0042176
  • GO:0043162
  • GO:0043226
  • GO:0044877
  • GO:0046761
  • GO:0051469
  • GO:0061024
  • GO:0061763
  • GO:0061952
  • GO:0071985
  • GO:0090148
  • GO:0097352
  • GO:1901673
  • GO:1902774
  • GO:1904930
  • ILMN_1251583
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CHMP6_MOUSE
sequenceLength 200
species [Species:48892] Mus musculus
stId uniprot:P0C0A3
url http://purl.uniprot.org/uniprot/P0C0A3
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