Reactome | UniProt:P09923 ALPI

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UniProt:P09923 ALPI Show undefined attributes

chain	signal peptide:1-19 chain:20-503 propeptide:504-528
checksum	465306BEDF9F0B79
comment	FUNCTION Alkaline phosphatase that can hydrolyze various phosphate compounds.CATALYTIC ACTIVITY a phosphate monoester + H2O = an alcohol + phosphateCOFACTOR Binds 1 Mg(2+) ion.COFACTOR Binds 2 Zn(2+) ions.COFACTOR Homodimer.INTERACTION In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP).SIMILARITY Belongs to the alkaline phosphatase family.ONLINE INFORMATION Alkaline phosphatase entry
crossReference	[DatabaseIdentifier:12816372] ZINC target:P09923 [DatabaseIdentifier:12812975] ZINC - Substances:PPBI_HUMAN [DatabaseIdentifier:12808674] ZINC - Predictions - Purchasable:PPBI_HUMAN [DatabaseIdentifier:12333569] RefSeq:NP_001622.2 [DatabaseIdentifier:12288943] Pharos - Targets:P09923 [DatabaseIdentifier:12250351] PRO:P09923 [DatabaseIdentifier:12128722] OpenTargets:ENSG00000163295 [DatabaseIdentifier:11844104] HPA:ENSG00000163295-ALPI [DatabaseIdentifier:11832480] HMDB Protein:HMDBP00093 [DatabaseIdentifier:11807058] GlyGen:P09923 [DatabaseIdentifier:11791099] GeneCards:ALPI [DatabaseIdentifier:11670670] ENSEMBL:ENST00000295463 [DatabaseIdentifier:11547971] ENSEMBL:ENSP00000295463 [DatabaseIdentifier:11456717] ENSEMBL:ENSG00000163295
databaseName	UniProt
dbId	62036
description	recommendedName: Intestinal-type alkaline phosphatase shortName: IAP shortName: Intestinal alkaline phosphatase ecNumber: 3.1.3.1
displayName	UniProt:P09923 ALPI
geneName	ALPI
identifier	P09923
isSequenceChanged	false
keyword	Calcium Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Hydrolase Lipoprotein Magnesium Membrane Metal-binding Proteomics identification Reference proteome Signal Zinc
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	ALPI
otherIdentifier	11732474_at 11749765_a_at 16892260 207140_PM_at 207140_at 211618_PM_s_at 211618_s_at 248 2532280 2532283 2532301 2532330 2532331 2532332 2532333 2532334 2532335 2532336 2532338 2532339 2532340 2532342 2532345 2532346 2532347 2532348 33523_at 8049137 A_23_P337658 GE57494 GO:0000287 GO:0002020 GO:0004035 GO:0005515 GO:0005576 GO:0005886 GO:0008270 GO:0016020 GO:0016311 GO:0016787 GO:0016791 GO:0046872 GO:0098552 HMNXSV003047453 HMNXSV003055708 Hs.284255.2.S1_3p_s_at ILMN_1752669 J03930_at PH_hs_0002926 TC02001400.hg g13787191_3p_at g13787191_3p_x_at g178443_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8943401] cleaved GPI-ALPI [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8940717] GPI-ALPI [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8878783] ALPI [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12728912] UCSC:P09923 ALPI [ReferenceDNASequence:12113455] OMIM:171740 ALPI [ReferenceDNASequence:12035412] NCBI Gene:248 ALPI [ReferenceDNASequence:11951319] Monarch:248 ALPI [ReferenceDNASequence:11864281] KEGG:hsa:248 ALPI [ReferenceDNASequence:11822765] HGNC:437 ALPI [ReferenceDNASequence:11435034] dbSNP Gene:248 ALPI [ReferenceDNASequence:11418704] CTD Gene:248 ALPI [ReferenceDNASequence:11398239] COSMIC - genes:ALPI ALPI [ReferenceDNASequence:11321530] BioGPS Gene:248 ALPI [ReferenceDNASequence:ensembl:ENSG00000163295] ENSEMBL:ENSG00000163295 ALPI
referenceTranscript	[ReferenceRNASequence:12515463] RefSeq:NM_001631.5 ALPI
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PPBI_HUMAN B2R7Y4 Q53S80 Q9UBV5 Q9UCL2
sequenceLength	528
species	[Species:48887] Homo sapiens
stId	uniprot:P09923
url	http://purl.uniprot.org/uniprot/P09923

Referrals

(interactor)	[UndirectedInteraction:11287353] UniProt:Q7Z3S9 <-> UniProt:P09923 (IntAct) [UndirectedInteraction:11271265] UniProt:P36404 <-> UniProt:P09923 (IntAct) [UndirectedInteraction:11264025] UniProt:Q8NBN7 <-> UniProt:P09923 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8943401] cleaved GPI-ALPI [extracellular region] [EntityWithAccessionedSequence:R-HSA-8940717] GPI-ALPI [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8878783] ALPI [plasma membrane]
(referenceSequence)	[GroupModifiedResidue:8941136] L-aspartic acid 1-amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 503 [GroupModifiedResidue:8940769] L-aspartic acid 1-amide (GPI-anchor amidated amino acid carboxyl end residue(1?)) at 503

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