UniProt:P09727 US11

chain
  • signal peptide:1-17
  • chain:18-215
checksum 6484695627C068E2
comment
  • FUNCTION Participates in the inhibition of the host immune response. Redirects newly synthesized major histocompatibility complex (MHC) class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.SUBUNIT Interacts with host TRAM1.SUBCELLULAR LOCATION Expressed at early and late period of virus infection.PTM N-glycosylated.PTM A fraction of newly synthesized molecules retain the signal peptide after the N-linked glycan has been attached and translation of the polypeptide has been completed. Delayed cleavage of the signal peptide is determined by the first four residues, as well as by the transmembrane region.SIMILARITY Belongs to the cytomegalovirus US6 family.
created [InstanceEdit:8943110] May, Bruce, 2016-10-24
crossReference
databaseName UniProt
dbId 8943118
description
  • recommendedName: Unique short US11 glycoprotein alternativeName: Protein HXLF1 alternativeName: gpUS11
displayName UniProt:P09727 US11
geneName
  • US11
identifier P09727
isSequenceChanged false
keyword
  • 3D-structure
  • Disulfide bond
  • Early protein
  • Glycoprotein
  • Host endoplasmic reticulum
  • Host membrane
  • Host-virus interaction
  • Immunoglobulin domain
  • Inhibition of host adaptive immune response by virus
  • Inhibition of host MHC class I molecule presentation by virus
  • Late protein
  • Membrane
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
  • Viral immunoevasion
modified [InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType Protein
name
  • US11
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • US11_HCMVA
  • Q7M6I9
sequenceLength 215
species [Species:2671791] Human cytomegalovirus
stId uniprot:P09727
url http://purl.uniprot.org/uniprot/P09727
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