Reactome | UniProt:P09661 SNRPA1

Schema > ReferenceGeneProduct > Entries

UniProt:P09661 SNRPA1 Show undefined attributes

chain	initiator methionine:1 chain:2-255
checksum	25902F07992B7209
comment	FUNCTION Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128).SUBUNIT Identified in the spliceosome B complex (PubMed:28781166, PubMed:32494006, PubMed:36797247). Identified in the spliceosome C complex (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:32494006, PubMed:36797247). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (PubMed:9531537). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B (PubMed:10339552). Contributes to the binding of stem loop IV of U2 snRNA with SNRPB2 (PubMed:27035939, PubMed:9716128).INTERACTION Belongs to the U2 small nuclear ribonucleoprotein A family.
crossReference	[DatabaseIdentifier:11458364] ENSEMBL:ENSG00000131876 [DatabaseIdentifier:12336910] RefSeq:NP_003081.2 [DatabaseIdentifier:12290077] Pharos - Targets:P09661 [DatabaseIdentifier:12251906] PRO:P09661 [DatabaseIdentifier:12140529] PDB:9FMD [DatabaseIdentifier:12145812] PDB:5Z56 [DatabaseIdentifier:12140527] PDB:7A5P [DatabaseIdentifier:12141229] PDB:8I0U [DatabaseIdentifier:12141231] PDB:5MQF [DatabaseIdentifier:12139761] PDB:8H6J [DatabaseIdentifier:12139749] PDB:6QX9 [DatabaseIdentifier:12140524] PDB:6QDV [DatabaseIdentifier:12139750] PDB:6AH0 [DatabaseIdentifier:12145806] PDB:7ABI [DatabaseIdentifier:12141230] PDB:8I0V [DatabaseIdentifier:12156139] PDB:7VPX [DatabaseIdentifier:12155847] PDB:6Y53 [DatabaseIdentifier:12139762] PDB:8H6K [DatabaseIdentifier:12140528] PDB:7W59 [DatabaseIdentifier:12156143] PDB:7EVO [DatabaseIdentifier:12139734] PDB:8H6E [DatabaseIdentifier:12139758] PDB:8R09 [DatabaseIdentifier:12139751] PDB:8R0A [DatabaseIdentifier:12148381] PDB:5Z58 [DatabaseIdentifier:12141232] PDB:6ID1 [DatabaseIdentifier:12145802] PDB:6FF7 [DatabaseIdentifier:12140526] PDB:7W5B [DatabaseIdentifier:12207961] PDB:1A9N [DatabaseIdentifier:12139755] PDB:8R08 [DatabaseIdentifier:12145807] PDB:8I0R [DatabaseIdentifier:12145811] PDB:5Z57 [DatabaseIdentifier:12142015] PDB:8HK1 [DatabaseIdentifier:12145808] PDB:8I0P [DatabaseIdentifier:12145809] PDB:8I0S [DatabaseIdentifier:12139756] PDB:8RM5 [DatabaseIdentifier:12142436] PDB:7ABG [DatabaseIdentifier:12139071] PDB:5YZG [DatabaseIdentifier:12145804] PDB:8CH6 [DatabaseIdentifier:12141227] PDB:6ID0 [DatabaseIdentifier:12155842] PDB:6Y5Q [DatabaseIdentifier:12140525] PDB:7W5A [DatabaseIdentifier:12139748] PDB:5O9Z [DatabaseIdentifier:12140514] PDB:5XJC [DatabaseIdentifier:12139070] PDB:8I0W [DatabaseIdentifier:12145810] PDB:8I0T [DatabaseIdentifier:12139759] PDB:8H6L [DatabaseIdentifier:12139744] PDB:6AHD [DatabaseIdentifier:12139746] PDB:8QXD [DatabaseIdentifier:12139754] PDB:8R0B [DatabaseIdentifier:12139757] PDB:8QO9 [DatabaseIdentifier:12139735] PDB:8QZS [DatabaseIdentifier:12140523] PDB:6ICZ [DatabaseIdentifier:12140516] PDB:8C6J [DatabaseIdentifier:12129867] OpenTargets:ENSG00000131876 [DatabaseIdentifier:11845226] HPA:ENSG00000131876-SNRPA1 [DatabaseIdentifier:11808240] GlyGen:P09661 [DatabaseIdentifier:11792231] GeneCards:SNRPA1 [DatabaseIdentifier:11672963] ENSEMBL:ENST00000254193 [DatabaseIdentifier:11550264] ENSEMBL:ENSP00000254193
databaseName	UniProt
dbId	71957
description	recommendedName: U2 small nuclear ribonucleoprotein A' shortName evidence="13 14"U2 snRNP A'
displayName	UniProt:P09661 SNRPA1
geneName	SNRPA1
identifier	P09661
isSequenceChanged	false
keyword	3D-structure Acetylation Direct protein sequencing Isopeptide bond Leucine-rich repeat mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	SNRPA1
otherIdentifier	11720945_x_at 11755612_s_at 11760017_a_at 16813900 206055_PM_s_at 206055_s_at 215722_PM_s_at 215722_s_at 216977_PM_x_at 216977_x_at 2501659 2501660 2501661 2501663 3642163 3642164 3642167 3642168 3642169 3642170 3642171 3642172 3642173 3642174 3642175 3642176 3642177 3642178 3642179 3642180 3642181 3642184 3642185 3642186 3642187 3642188 3642189 3642191 3642192 3642193 3642194 3642195 37585_at 3966224 6627 74683_at 7991598 8180357 GE59711 GO:0000398 GO:0003723 GO:0005515 GO:0005634 GO:0005654 GO:0005681 GO:0005684 GO:0005686 GO:0006397 GO:0007283 GO:0008380 GO:0016071 GO:0016604 GO:0016607 GO:0022414 GO:0030532 GO:0030620 GO:0065003 GO:0071005 GO:0071007 GO:0071013 GO:1903241 GO:1990904 HMNXSV003046596 Hs.80506.2.S1_3p_a_at ILMN_1715179 PH_hs_0039558 TC15002007.hg X13482_at g4507120_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-71958] SNRPA1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000131876] ENSEMBL:ENSG00000131876 SNRPA1 [ReferenceDNASequence:12729898] UCSC:P09661 SNRPA1 [ReferenceDNASequence:12114481] OMIM:603521 SNRPA1 [ReferenceDNASequence:12036971] NCBI Gene:6627 SNRPA1 [ReferenceDNASequence:11952878] Monarch:6627 SNRPA1 [ReferenceDNASequence:11865679] KEGG:hsa:6627 SNRPA1 [ReferenceDNASequence:11823910] HGNC:11152 SNRPA1 [ReferenceDNASequence:11435119] dbSNP Gene:6627 SNRPA1 [ReferenceDNASequence:11420293] CTD Gene:6627 SNRPA1 [ReferenceDNASequence:11398316] COSMIC - genes:SNRPA1 SNRPA1 [ReferenceDNASequence:11323089] BioGPS Gene:6627 SNRPA1
referenceTranscript	[ReferenceRNASequence:12518795] RefSeq:NM_003090.4 SNRPA1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RU2A_HUMAN B2R5I6 Q8TBD2
sequenceLength	255
species	[Species:48887] Homo sapiens
stId	uniprot:P09661
url	http://purl.uniprot.org/uniprot/P09661

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[EntityWithAccessionedSequence:R-HSA-71958] SNRPA1 [nucleoplasm]

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