Reactome | UniProt:P09012 SNRPA

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UniProt:P09012 SNRPA Show undefined attributes

chain	initiator methionine:1 chain:2-282
checksum	9426E83EE5A22894
comment	FUNCTION Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.SUBUNIT U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ. Interacts with IVNS1ABP (via BACK domain); the interaction is indirect (PubMed:30538201).INTERACTION Belongs to the RRM U1 A/B'' family.
crossReference	[DatabaseIdentifier:12182648] PDB:8GXB [DatabaseIdentifier:12322831] RefSeq:NP_004587.1 [DatabaseIdentifier:12286104] Pharos - Targets:P09012 [DatabaseIdentifier:12245883] PRO:P09012 [DatabaseIdentifier:12182666] PDB:6XH1 [DatabaseIdentifier:12182685] PDB:4W92 [DatabaseIdentifier:12182701] PDB:3MXH [DatabaseIdentifier:12182647] PDB:6SQN [DatabaseIdentifier:12182638] PDB:6LAZ [DatabaseIdentifier:12182619] PDB:3IIN [DatabaseIdentifier:12182684] PDB:5DDO [DatabaseIdentifier:12182690] PDB:1SJF [DatabaseIdentifier:12182632] PDB:3CUN [DatabaseIdentifier:12182645] PDB:3HHN [DatabaseIdentifier:12182688] PDB:1M5K [DatabaseIdentifier:12182670] PDB:6XH2 [DatabaseIdentifier:12182621] PDB:3G9C [DatabaseIdentifier:12182617] PDB:7QR3 [DatabaseIdentifier:12182692] PDB:1M5V [DatabaseIdentifier:12182657] PDB:1OIA [DatabaseIdentifier:12182696] PDB:1NU4 [DatabaseIdentifier:12182650] PDB:1AUD [DatabaseIdentifier:12182669] PDB:3IWN [DatabaseIdentifier:12182625] PDB:3G96 [DatabaseIdentifier:12182675] PDB:6SR7 [DatabaseIdentifier:12182637] PDB:1FHT [DatabaseIdentifier:12182624] PDB:3G8T [DatabaseIdentifier:12182644] PDB:7DLZ [DatabaseIdentifier:12182665] PDB:2OJ3 [DatabaseIdentifier:12182626] PDB:3K0J [DatabaseIdentifier:12182659] PDB:1VC0 [DatabaseIdentifier:12164245] PDB:9QEQ [DatabaseIdentifier:12182677] PDB:1M5P [DatabaseIdentifier:12182682] PDB:4W90 [DatabaseIdentifier:12182699] PDB:3UCU [DatabaseIdentifier:12182671] PDB:4PR6 [DatabaseIdentifier:12182658] PDB:2U1A [DatabaseIdentifier:12182693] PDB:3BO2 [DatabaseIdentifier:12182678] PDB:1M5O [DatabaseIdentifier:12182651] PDB:1ZZN [DatabaseIdentifier:12182653] PDB:1DRZ [DatabaseIdentifier:12182687] PDB:7DWH [DatabaseIdentifier:12182656] PDB:1VC5 [DatabaseIdentifier:12182703] PDB:1SJ3 [DatabaseIdentifier:12182698] PDB:3BO4 [DatabaseIdentifier:12182697] PDB:3BO3 [DatabaseIdentifier:12182681] PDB:3R1L [DatabaseIdentifier:12182683] PDB:5DDP [DatabaseIdentifier:12182704] PDB:3EGZ [DatabaseIdentifier:12182636] PDB:6LAX [DatabaseIdentifier:12182633] PDB:6LAS [DatabaseIdentifier:12182694] PDB:3UD4 [DatabaseIdentifier:12182667] PDB:6XH0 [DatabaseIdentifier:12182643] PDB:8GXC [DatabaseIdentifier:12182661] PDB:1VBZ [DatabaseIdentifier:12182702] PDB:1SJ4 [DatabaseIdentifier:12182662] PDB:1VBY [DatabaseIdentifier:12182635] PDB:8JY0 [DatabaseIdentifier:12182628] PDB:4YB1 [DatabaseIdentifier:12182674] PDB:6SQV [DatabaseIdentifier:12182700] PDB:3R1H [DatabaseIdentifier:12182641] PDB:1DZ5 [DatabaseIdentifier:12182623] PDB:1U6B [DatabaseIdentifier:12182686] PDB:5DDR [DatabaseIdentifier:12182654] PDB:3L3C [DatabaseIdentifier:12182680] PDB:3UCZ [DatabaseIdentifier:12182679] PDB:2NZ4 [DatabaseIdentifier:12182672] PDB:6SQT [DatabaseIdentifier:12182691] PDB:3UD3 [DatabaseIdentifier:12182642] PDB:3CUL [DatabaseIdentifier:12139749] PDB:6QX9 [DatabaseIdentifier:12182618] PDB:5FJ4 [DatabaseIdentifier:12182634] PDB:6LAU [DatabaseIdentifier:12182676] PDB:7LHX [DatabaseIdentifier:12182668] PDB:6XH3 [DatabaseIdentifier:12182695] PDB:4C4W [DatabaseIdentifier:12182622] PDB:7QR4 [DatabaseIdentifier:12182673] PDB:3P49 [DatabaseIdentifier:12182660] PDB:4PRF [DatabaseIdentifier:12182627] PDB:3MUM [DatabaseIdentifier:12156139] PDB:7VPX [DatabaseIdentifier:12182689] PDB:5DDQ [DatabaseIdentifier:12182629] PDB:7AEP [DatabaseIdentifier:12182664] PDB:1VC6 [DatabaseIdentifier:12182663] PDB:1VBX [DatabaseIdentifier:12182639] PDB:1URN [DatabaseIdentifier:12182652] PDB:2OIH [DatabaseIdentifier:12164223] PDB:7B0Y [DatabaseIdentifier:12182655] PDB:7D7V [DatabaseIdentifier:12182646] PDB:3IRW [DatabaseIdentifier:11451291] ENSEMBL:ENSG00000077312 [DatabaseIdentifier:11540672] ENSEMBL:ENSP00000243563 [DatabaseIdentifier:11663371] ENSEMBL:ENST00000243563 [DatabaseIdentifier:11788213] GeneCards:SNRPA [DatabaseIdentifier:11803760] GlyGen:P09012 [DatabaseIdentifier:11841269] HPA:ENSG00000077312-SNRPA [DatabaseIdentifier:12125830] OpenTargets:ENSG00000077312 [DatabaseIdentifier:12182616] PDB:3MUT [DatabaseIdentifier:12182631] PDB:2A3J [DatabaseIdentifier:12182620] PDB:3MUV [DatabaseIdentifier:12182630] PDB:3MUR [DatabaseIdentifier:12182640] PDB:3G8S [DatabaseIdentifier:12182649] PDB:6SQQ [DatabaseIdentifier:12174473] PDB:3PGW
databaseName	UniProt
dbId	71914
description	recommendedName: U1 small nuclear ribonucleoprotein A shortName: U1 snRNP A shortName: U1-A shortName: U1A
displayName	UniProt:P09012 SNRPA
geneName	SNRPA
identifier	P09012
isSequenceChanged	false
keyword	3D-structure Acetylation Direct protein sequencing Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	SNRPA
otherIdentifier	11744270_a_at 11748453_x_at 11756298_a_at 11756299_x_at 16862333 201770_PM_at 201770_at 3833760 3833761 3833762 3833763 3833764 3833766 3833767 3833768 3833770 3833771 3833772 3833773 3833774 3833775 3833776 3833779 3833780 3833788 40842_at 6626 8028916 85973_at A_14_P128472 A_23_P164718 A_24_P219757 A_24_P250333 A_24_P250335 GE59682 GO:0000398 GO:0003676 GO:0003677 GO:0003723 GO:0005515 GO:0005634 GO:0005654 GO:0005681 GO:0005685 GO:0006397 GO:0008380 GO:0016071 GO:0030619 GO:0042802 GO:0046540 GO:0097525 GO:1990446 GO:1990904 ILMN_1779399 M60784_s_at PH_hs_0010385 PH_hs_0035642 TC19000567.hg g4759155_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-71915] SNRPA [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000077312] ENSEMBL:ENSG00000077312 SNRPA [ReferenceDNASequence:12725702] UCSC:P09012 SNRPA [ReferenceDNASequence:11316682] BioGPS Gene:6626 SNRPA [ReferenceDNASequence:11397886] COSMIC - genes:SNRPA SNRPA [ReferenceDNASequence:11414357] CTD Gene:6626 SNRPA [ReferenceDNASequence:11434641] dbSNP Gene:6626 SNRPA [ReferenceDNASequence:11819863] HGNC:11151 SNRPA [ReferenceDNASequence:11859948] KEGG:hsa:6626 SNRPA [ReferenceDNASequence:11946471] Monarch:6626 SNRPA [ReferenceDNASequence:12030564] NCBI Gene:6626 SNRPA [ReferenceDNASequence:12111012] OMIM:182285 SNRPA
referenceTranscript	[ReferenceRNASequence:12504802] RefSeq:NM_004596.5 SNRPA
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SNRPA_HUMAN
sequenceLength	282
species	[Species:48887] Homo sapiens
stId	uniprot:P09012
url	http://purl.uniprot.org/uniprot/P09012

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-71915] SNRPA [nucleoplasm]

(interactor)

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