Reactome | UniProt:P08962 CD63

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UniProt:P08962 CD63 Show undefined attributes

chain	initiator methionine:1 chain:2-238
checksum	85AC8E235C6E425F
comment	FUNCTION Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.SUBUNIT Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1 (PubMed:16917503, PubMed:24635319). Interacts with CD9. Identified in a complex with CD9 and ITGB3 (PubMed:19640571). Interacts with PMEL (PubMed:21962903). Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes (PubMed:23632027). Interacts with SYT7 (By similarity).INTERACTION Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).ALTERNATIVE PRODUCTS Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.PTM Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).MISCELLANEOUS Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.MISCELLANEOUS This antigen is associated with early stages of melanoma tumor progression.SIMILARITY Belongs to the tetraspanin (TM4SF) family.
crossReference	[DatabaseIdentifier:12383976] RefSeq:NP_001244329.1 [DatabaseIdentifier:12383973] RefSeq:NP_001771.1 [DatabaseIdentifier:12383975] RefSeq:NP_001244318.1 [DatabaseIdentifier:12383967] RefSeq:NP_001254627.1 [DatabaseIdentifier:12383970] RefSeq:NP_001244320.1 [DatabaseIdentifier:11479623] ENSEMBL:ENSG00000135404 [DatabaseIdentifier:11579920] ENSEMBL:ENSP00000393502 [DatabaseIdentifier:11579923] ENSEMBL:ENSP00000448091 [DatabaseIdentifier:11579917] ENSEMBL:ENSP00000447356 [DatabaseIdentifier:11579919] ENSEMBL:ENSP00000447730 [DatabaseIdentifier:11579918] ENSEMBL:ENSP00000449337 [DatabaseIdentifier:11579922] ENSEMBL:ENSP00000257857 [DatabaseIdentifier:11579921] ENSEMBL:ENSP00000446807 [DatabaseIdentifier:11702617] ENSEMBL:ENST00000549117 [DatabaseIdentifier:11702619] ENSEMBL:ENST00000552754 [DatabaseIdentifier:11702622] ENSEMBL:ENST00000257857 [DatabaseIdentifier:11702618] ENSEMBL:ENST00000550776 [DatabaseIdentifier:11702620] ENSEMBL:ENST00000546939 [DatabaseIdentifier:11702621] ENSEMBL:ENST00000552692 [DatabaseIdentifier:11702616] ENSEMBL:ENST00000420846 [DatabaseIdentifier:11792320] GeneCards:CD63 [DatabaseIdentifier:11808334] GlyGen:P08962 [DatabaseIdentifier:11845315] HPA:ENSG00000135404-CD63 [DatabaseIdentifier:12129955] OpenTargets:ENSG00000135404 [DatabaseIdentifier:12272621] PRO:P08962 [DatabaseIdentifier:12290165] Pharos - Targets:P08962 [DatabaseIdentifier:12383972] RefSeq:NP_001244330.1 [DatabaseIdentifier:12383979] RefSeq:NP_001400211.1 [DatabaseIdentifier:12383980] RefSeq:NP_001244319.1 [DatabaseIdentifier:12383968] RefSeq:NP_001400214.1 [DatabaseIdentifier:12383974] RefSeq:NP_001400212.1 [DatabaseIdentifier:12383977] RefSeq:NP_001400213.1 [DatabaseIdentifier:12383971] RefSeq:NP_001244321.1 [DatabaseIdentifier:12383978] RefSeq:NP_001400210.1 [DatabaseIdentifier:12383969] RefSeq:NP_001400215.1
databaseName	UniProt
dbId	51684
description	recommendedName: CD63 antigen alternativeName: Granulophysin alternativeName: fullName evidence="19 21"Lysosomal-associated membrane protein 3 shortName evidence="19 21"LAMP-3 alternativeName: fullName evidence="21"Lysosome integral membrane protein 1 shortName evidence="21"Limp1 alternativeName: fullName evidence="20 21"Melanoma-associated antigen ME491 alternativeName: OMA81H alternativeName: Ocular melanoma-associated antigen alternativeName: Tetraspanin-30 shortName: Tspan-30 cdAntigenNameCD63/cdAntigenName
displayName	UniProt:P08962 CD63
geneName	CD63 MLA1 TSPAN30
identifier	P08962
isSequenceChanged	false
keyword	Alternative splicing Cell membrane Direct protein sequencing Endosome Glycoprotein Lipoprotein Lysosome Membrane Palmitate Protein transport Proteomics identification Reference proteome Secreted Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	CD63
otherIdentifier	11744260_a_at 11757417_x_at 16765744 200663_PM_at 200663_at 3457158 3457159 3457161 3457162 3457163 3457164 3457165 3457166 3457167 3457168 3457169 3457170 3457171 3457173 3457174 3457175 3457176 3457177 3457179 3457180 3457181 3457182 3457183 3457184 3457185 3457186 3457187 37003_at 7963911 967 A_23_P139476 A_24_P270144 GE61263 GO:0002092 GO:0005515 GO:0005576 GO:0005615 GO:0005654 GO:0005764 GO:0005765 GO:0005768 GO:0005770 GO:0005771 GO:0005886 GO:0007155 GO:0007160 GO:0009986 GO:0010008 GO:0010633 GO:0015031 GO:0016020 GO:0016477 GO:0030154 GO:0030855 GO:0031088 GO:0031410 GO:0031902 GO:0031904 GO:0031982 GO:0032585 GO:0032991 GO:0035577 GO:0035646 GO:0042470 GO:0043226 GO:0043473 GO:0044877 GO:0045785 GO:0045807 GO:0048757 GO:0048870 GO:0050931 GO:0070062 GO:0097487 GO:1900746 GO:1901379 GO:2001046 HMNXSV003055033 HMNXSV003057430 ILMN_1753468 PH_hs_0026052 TC12001584.hg X62654_rna1_at g4502678_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6799157] CD63 [azurophil granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-114583] CD63 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-51683] CD63 [platelet dense granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000135404] ENSEMBL:ENSG00000135404 CD63 [ReferenceDNASequence:12742239] UCSC:P08962 CD63 [ReferenceDNASequence:11345305] BioGPS Gene:967 CD63 [ReferenceDNASequence:11400070] COSMIC - genes:CD63 CD63 [ReferenceDNASequence:11420422] CTD Gene:967 CD63 [ReferenceDNASequence:11437158] dbSNP Gene:967 CD63 [ReferenceDNASequence:11824000] HGNC:1692 CD63 [ReferenceDNASequence:11885617] KEGG:hsa:967 CD63 [ReferenceDNASequence:11975094] Monarch:967 CD63 [ReferenceDNASequence:12059187] NCBI Gene:967 CD63 [ReferenceDNASequence:12114565] OMIM:155740 CD63
referenceTranscript	[ReferenceRNASequence:12565759] RefSeq:NM_001413286.1 CD63 [ReferenceRNASequence:12565757] RefSeq:NM_001267698.2 CD63 [ReferenceRNASequence:12565750] RefSeq:NM_001780.6 CD63 [ReferenceRNASequence:12565761] RefSeq:NM_001257391.2 CD63 [ReferenceRNASequence:12565762] RefSeq:NM_001257392.1 CD63 [ReferenceRNASequence:12565751] RefSeq:NM_001257401.2 CD63 [ReferenceRNASequence:12565756] RefSeq:NM_001413285.1 CD63 [ReferenceRNASequence:12565755] RefSeq:NM_001413282.1 CD63 [ReferenceRNASequence:12565758] RefSeq:NM_001413284.1 CD63 [ReferenceRNASequence:12565752] RefSeq:NM_001257400.2 CD63 [ReferenceRNASequence:12565749] RefSeq:NM_001257389.2 CD63 [ReferenceRNASequence:12565753] RefSeq:NM_001413281.1 CD63 [ReferenceRNASequence:12565760] RefSeq:NM_001257390.2 CD63 [ReferenceRNASequence:12565754] RefSeq:NM_001413283.1 CD63
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CD63_HUMAN F8VZE2 Q5TZP3 Q8N6Z9 Q9UCG6
sequenceLength	238
species	[Species:48887] Homo sapiens
stId	uniprot:P08962
url	http://purl.uniprot.org/uniprot/P08962

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6799157] CD63 [azurophil granule membrane] [EntityWithAccessionedSequence:R-HSA-114583] CD63 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-51683] CD63 [platelet dense granule membrane]
(interactor)	[UndirectedInteraction:11182173] UniProt:Q2M3M2 <-> UniProt:P08962 (IntAct) [UndirectedInteraction:11235985] UniProt:P05556 <-> UniProt:P08962 (IntAct) [UndirectedInteraction:11262667] UniProt:P01033 <-> UniProt:P08962 (IntAct) [UndirectedInteraction:11271673] UniProt:P17931 <-> UniProt:P08962 (IntAct)