Reactome | UniProt:P08908 HTR1A

Schema > ReferenceGeneProduct > Entries

UniProt:P08908 HTR1A Show undefined attributes

chain	chain:1-422
checksum	762664FCF62CFD8F
comment	FUNCTION G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:38552625, PubMed:8138923, PubMed:8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:8138923, PubMed:8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:33762731, PubMed:35610220). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the response to anxiogenic stimuli (PubMed:18476671, PubMed:20363322, PubMed:20945968).ACTIVITY REGULATION G-protein coupled receptor activity is regulated by lipids: phosphatidylinositol 4-phosphate increases HTR1A-mediated activity (PubMed:33762731). Binding to aripiprazol drug is regulated by cholesterol, which shapes the ligand-binding pocket, determining the specificity for aripiprazol (PubMed:33762731). Activated by IHCH-7179 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and as an antagonist inhibitor for HTR2A (PubMed:38552625). Activated by SEP-363856 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and TAAR1 (PubMed:37935376, PubMed:37935377).SUBUNIT Heterodimer; heterodimerizes with GPER1 (PubMed:23300088). Interacts with YIF1B (By similarity). Interacts with GPR39 and GALR1 (PubMed:26365466).INTERACTION Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
crossReference	[DatabaseIdentifier:11479909] ENSEMBL:ENSG00000178394 [DatabaseIdentifier:12817869] ZINC - World Drugs:5HT1A_HUMAN [DatabaseIdentifier:12814342] ZINC target:P08908 [DatabaseIdentifier:12811035] ZINC - Substances:5HT1A_HUMAN [DatabaseIdentifier:12808315] ZINC - Predictions - Purchasable:5HT1A_HUMAN [DatabaseIdentifier:12807603] ZINC - Metabolites:5HT1A_HUMAN [DatabaseIdentifier:12806397] ZINC - Investigational:5HT1A_HUMAN [DatabaseIdentifier:12805337] ZINC - FDA approved:5HT1A_HUMAN [DatabaseIdentifier:12804145] ZINC - Biogenic:5HT1A_HUMAN [DatabaseIdentifier:11580302] ENSEMBL:ENSP00000316244 [DatabaseIdentifier:11703001] ENSEMBL:ENST00000323865 [DatabaseIdentifier:11778823] Guide to Pharmacology - Targets:1 [DatabaseIdentifier:11792510] GeneCards:HTR1A [DatabaseIdentifier:11808586] GlyGen:P08908 [DatabaseIdentifier:11829134] HMDB Protein:HMDBP02566 [DatabaseIdentifier:11845499] HPA:ENSG00000178394-HTR1A [DatabaseIdentifier:12130145] OpenTargets:ENSG00000178394 [DatabaseIdentifier:12134912] Orphanet:HTR1A [DatabaseIdentifier:12164848] PDB:8JT6 [DatabaseIdentifier:12164990] PDB:8PKM [DatabaseIdentifier:12164935] PDB:7E2Y [DatabaseIdentifier:12165009] PDB:8FY8 [DatabaseIdentifier:12211763] PDB:9MD1 [DatabaseIdentifier:12165014] PDB:8FYL [DatabaseIdentifier:12165013] PDB:8FYX [DatabaseIdentifier:12164850] PDB:8JSP [DatabaseIdentifier:12192233] PDB:9DYE [DatabaseIdentifier:12164998] PDB:8W8B [DatabaseIdentifier:12213341] PDB:9DYF [DatabaseIdentifier:12164933] PDB:7E2Z [DatabaseIdentifier:12164978] PDB:8PJK [DatabaseIdentifier:12192232] PDB:9DYD [DatabaseIdentifier:12213342] PDB:9GL2 [DatabaseIdentifier:12165012] PDB:8FYT [DatabaseIdentifier:12164934] PDB:7E2X [DatabaseIdentifier:12165000] PDB:8FYE [DatabaseIdentifier:12272943] PRO:P08908 [DatabaseIdentifier:12290352] Pharos - Targets:P08908 [DatabaseIdentifier:12384604] RefSeq:NP_000515.2
databaseName	UniProt
dbId	49164
description	recommendedName: 5-hydroxytryptamine receptor 1A shortName evidence="25"5-HT-1A shortName evidence="25"5-HT1A alternativeName: fullName evidence="24"G-21 alternativeName: Serotonin receptor 1A
displayName	UniProt:P08908 HTR1A
geneName	HTR1A ADRB2RL1 ADRBRL1
identifier	P08908
isSequenceChanged	false
keyword	3D-structure Behavior Cell membrane Cell projection Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	HTR1A
otherIdentifier	11741081_a_at 11741082_at 16996667 16996670 221351_PM_at 221351_at 236714_PM_at 236714_at 2859388 2859389 2859390 2859391 2859392 2859393 2859394 2859395 2859396 2859397 2859398 3350 47305_at 8112333 ADDON002886.hg A_24_P97687 GE547469 GE554019 GO:0001586 GO:0001662 GO:0003013 GO:0004930 GO:0004993 GO:0005515 GO:0005886 GO:0007165 GO:0007186 GO:0007187 GO:0007189 GO:0007198 GO:0007210 GO:0007214 GO:0007268 GO:0008284 GO:0014062 GO:0016020 GO:0019229 GO:0030425 GO:0030534 GO:0030594 GO:0035640 GO:0042053 GO:0042428 GO:0042995 GO:0045202 GO:0046883 GO:0050795 GO:0051378 GO:0090722 GO:0098664 GO:0099589 HMNXSV003031338 HMNXSV003052920 Hs.56400.0.A1_3p_at Hs.56400.0.A1_3p_x_at ILMN_1813690 M83181_at TC05001404.hg g4504530_3p_at p13190
physicalEntity	[EntityWithAccessionedSequence:R-HSA-390971] HTR1A [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000178394] ENSEMBL:ENSG00000178394 HTR1A [ReferenceDNASequence:12742398] UCSC:P08908 HTR1A [ReferenceDNASequence:11345544] BioGPS Gene:3350 HTR1A [ReferenceDNASequence:11400097] COSMIC - genes:HTR1A HTR1A [ReferenceDNASequence:11420695] CTD Gene:3350 HTR1A [ReferenceDNASequence:11437187] dbSNP Gene:3350 HTR1A [ReferenceDNASequence:11824190] HGNC:5286 HTR1A [ReferenceDNASequence:11885810] KEGG:hsa:3350 HTR1A [ReferenceDNASequence:11975333] Monarch:3350 HTR1A [ReferenceDNASequence:12059426] NCBI Gene:3350 HTR1A [ReferenceDNASequence:12114729] OMIM:109760 HTR1A
referenceTranscript	[ReferenceRNASequence:12566385] RefSeq:NM_000524.4 HTR1A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	5HT1A_HUMAN Q6LAE7
sequenceLength	422
species	[Species:48887] Homo sapiens
stId	uniprot:P08908
url	http://purl.uniprot.org/uniprot/P08908

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-390971] HTR1A [plasma membrane]
(interactor)	[UndirectedInteraction:11160765] UniProt:P11362 <-> UniProt:P08908 (IntAct) [UndirectedInteraction:11164655] UniProt:P08908 <-> UniProt:P47211 (IntAct) [UndirectedInteraction:11164657] UniProt:P08908 <-> UniProt:O43194 (IntAct) [UndirectedInteraction:11164659] UniProt:P08908 <-> UniProt:P08908 (IntAct) [UndirectedInteraction:11164659] UniProt:P08908 <-> UniProt:P08908 (IntAct)