UniProt:P08621 SNRNP70

chain
  • initiator methionine:1
  • chain:2-437
checksum F1020BF5C40CF97D
comment
  • FUNCTION Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158).FUNCTION Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.FUNCTION Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.SUBUNIT Component of the U1 snRNP (PubMed:19325628, PubMed:21113136, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:21113136, PubMed:25555158). Interacts with SCNM1 (By similarity). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (PubMed:9531537). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10 (PubMed:10339552). Interacts with dephosphorylated SFRS13A and SFPQ (PubMed:11514619, PubMed:14765198). Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2 (PubMed:11448987, PubMed:14561889, PubMed:9447963). Interacts with GEMIN5 (PubMed:25911097). Interacts with FUS.INTERACTION Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.ALTERNATIVE PRODUCTS The RRM domain mediates interaction with U1 RNA.PTM The N-terminus is blocked.PTM Extensively phosphorylated on serine residues in the C-terminal region.MISCELLANEOUS Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 71912
description
  • recommendedName: U1 small nuclear ribonucleoprotein 70 kDa shortName evidence="23"U1 snRNP 70 kDa shortName evidence="21 22"U1-70K shortName: snRNP70
displayName UniProt:P08621 SNRNP70
geneName
  • SNRNP70
  • RNPU1Z
  • RPU1
  • SNRP70
  • U1AP1
identifier P08621
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Direct protein sequencing
  • Isopeptide bond
  • mRNA processing
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Ribonucleoprotein
  • RNA-binding
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • SNRNP70
otherIdentifier
  • 11754463_a_at
  • 11755283_a_at
  • 11759421_at
  • 16863974
  • 201221_PM_s_at
  • 201221_s_at
  • 213121_PM_at
  • 213121_at
  • 3838184
  • 3838186
  • 3838187
  • 3838188
  • 3838189
  • 3838190
  • 3838191
  • 3838192
  • 3838194
  • 3838195
  • 3838198
  • 3838199
  • 3838200
  • 3838201
  • 3838203
  • 3838204
  • 3838205
  • 3838206
  • 3838207
  • 3838208
  • 3838209
  • 3838210
  • 3838211
  • 3838212
  • 3838213
  • 3838214
  • 3838215
  • 3838216
  • 3838217
  • 3838218
  • 3838222
  • 3838223
  • 3838224
  • 3838225
  • 3838226
  • 3838227
  • 3838228
  • 3838237
  • 40875_s_at
  • 6625
  • 8030199
  • 87370_at
  • A_14_P105747
  • A_23_P4902
  • A_23_P4909
  • GE79537
  • GO:0000398
  • GO:0003676
  • GO:0003723
  • GO:0003729
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005681
  • GO:0005685
  • GO:0006397
  • GO:0016071
  • GO:0016607
  • GO:0030619
  • GO:0043202
  • GO:0043484
  • GO:0048026
  • GO:0061084
  • GO:0071004
  • GO:0071300
  • GO:0071356
  • GO:0071560
  • GO:1904715
  • GO:1990446
  • GO:1990904
  • HMNXSV003024985
  • Hs.174051.1.S1_3p_at
  • ILMN_1683049
  • ILMN_1732053
  • ILMN_2380839
  • PH_hs_0010437
  • TC19000724.hg
  • TC19002196.hg
  • TC19002197.hg
  • X04654_s_at
  • g4507118_3p_a_at
  • g4507118_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RU17_HUMAN
  • B3KUA3
  • P78493
  • P78494
  • Q15364
  • Q15686
  • Q15687
  • Q15689
  • Q99377
  • Q9UE45
  • Q9UE46
  • Q9UE47
  • Q9UE48
  • Q9UFQ6
sequenceLength 437
species [Species:48887] Homo sapiens
stId uniprot:P08621
url http://purl.uniprot.org/uniprot/P08621
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