UniProt:P08151 GLI1

chain
  • chain:1-1106
checksum E29B11D1A6CD3D91
comment
  • FUNCTION Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407).FUNCTION Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.SUBUNIT Interacts with KIF7 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441). Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, PubMed:24217340, PubMed:24311597, PubMed:28965847).INTERACTION Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441).SUBCELLULAR LOCATION Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761).INDUCTION Isoform 1 and isoform 2 are amplified in glioblastoma cells.PTM Phosphorylated in vitro by ULK3.PTM Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1.PTM Ubiquitinated by the CRL2(FEM1B) complex, suppressing GLI1 transcriptional activator activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease may be caused by variants affecting the gene represented in this entry.MISCELLANEOUS Undetectable in normal cells but highly expressed in cancer cells.SIMILARITY Belongs to the GLI C2H2-type zinc-finger protein family.
crossReference
databaseName UniProt
dbId 55674
description
  • recommendedName: Zinc finger protein GLI1 alternativeName: Glioma-associated oncogene alternativeName: Oncogene GLI
displayName UniProt:P08151 GLI1
geneName
  • GLI1
  • GLI
identifier P08151
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Activator
  • Alternative splicing
  • Cytoplasm
  • Developmental protein
  • Differentiation
  • Disease variant
  • DNA-binding
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Proto-oncogene
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • GLI1
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GLI1_HUMAN
  • D0EUY3
  • E9PQQ9
  • F5H6H8
  • Q8TDN9
sequenceLength 1106
species [Species:48887] Homo sapiens
stId uniprot:P08151
url http://purl.uniprot.org/uniprot/P08151

Referrals

(referenceEntity)
(referenceSequence)
(interactor)
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